Eweitz

Senescence and autophagy in cancer

Visual cycle

IL23 inhibitors in inflammatory bowel disease

Prostaglandin and leukotriene metabolism in senescence

Psoriasis mechanisms and therapies

EGFR tyrosine kinase inhibitor resistance

MAPK signaling and ARTD family members

Wnt/Beta-catenin signaling and ARTD family members

11p11.2 copy number variation syndrome

Leukocyte-intrinsic Hippo pathway functions

Envelope proteins and their potential roles in EDMD physiopathology

Tryptophan degradation via kynurenine

ATR signaling

Oxytocin signaling

Ubiquinol-6 biosynthesis from 4-hydroxybenzoate

Valine biosynthesis

UDP-N-acetylgalactosamine biosynthesis

Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells

Cell cycle and cell division

De novo biosynthesis of pyrimidine deoxyribonucleotides

Androgen receptor network in prostate cancer

De novo biosynthesis of purine nucleotides

Cholesterol biosynthesis

De novo biosynthesis of pyrimidine ribonucleotides

De novo NAD biosynthesis

Ether lipid biosynthesis

Intracellular trafficking proteins involved in CMT neuropathy

Glutathione-glutaredoxin redox reaction

ATM signaling in development and disease

Nicotine effect on chromaffin cells

Colanic acid building blocks biosynthesis

Primary focal segmental glomerulosclerosis (FSGS)

Fragile X syndrome

AMPK regulation of mammary milk protein synthesis

GABA receptor signaling

Effect of omega-3 PUFA on Huntington's disease pathways

AKT signaling and ARTD family members

NF-kB signaling and ARTD family members

Ferroptosis

ATM signaling

Wnt signaling

Wnt signaling, NetPath

Cholesterol biosynthesis pathway

Wnt signaling in adult hippocampal neurogenesis

JAK/STAT signaling and ARTD family members

Vitamin A and carotenoid metabolism

Pathophysiology of age-related macular degeneration

Retinoid metabolism in retina: healthy vs. RLBP1-deficient

Fatty acid elongation

Pluripotent stem cell differentiation pathway

Pro-survival signaling of neuroprotectin D1

Age-related macular degeneration

Methionine degradation

NAD biosynthesis II from tryptophan

Parkinson's disease pathway

Phenylalanine degradation

Lactose degradation and galactose metabolism

Chorismate biosynthesis

Allantoin degradation

Arginine biosynthesis

Aerobic glycerol catabolism

Aspartate biosynthesis

Homocysteine and cysteine interconversion

Estrogen receptor pathway

DNA replication

NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde

Estrogen signaling

LncRNA-like NMRK2 in translocation renal cell carcinoma

Pathways into methionine and folate cycles

ADHD and autism (ASD) pathways

Metabolic pathways of fibroblasts

Creatine pathway

DNA replication

Small cell lung cancer

Cerebral organic acidurias, including diseases

One-carbon metabolism

Non-small cell lung cancer

Development and heterogeneity of the ILC family

IL-1 signaling pathway

Glycine cleavage

Focal adhesion

Mammary gland development: pregnancy and lactation - stage 3 of 4

Complement system

One-carbon metabolism

Glycine metabolism

One-carbon metabolism

Statin pathway

Eicosanoid metabolism via cytochrome P450 monooxygenases

Eicosanoid metabolism via cytochrome P450 monooxygenases pathway

Head and neck squamous cell carcinoma

Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

GPCRs, small ligand

Senescence-associated secretory phenotype (SASP)

Aspirin prevention of cancer metastasis

STING pathway in Kawasaki-like disease and COVID-19

CAMKK2 pathway

mBDNF and proBDNF regulation of GABA neurotransmission

TGF-beta receptor signaling in skeletal dysplasias

Cholesterol biosynthesis with skeletal dysplasias

Purine metabolism

FGF23 signaling in hypophosphatemic rickets and related disorders

Multiple epiphyseal dysplasia and pseudoachondroplasia genes

Autosomal recessive osteopetrosis pathways

Osteoblast differentiation and related diseases

Somitogenesis in the context of spondylocostal dysostosis

Proteoglycan biosynthesis

FGFR3 signaling in chondrocyte proliferation and terminal differentiation

PKC-gamma calcium signaling in ataxia

Ketogenesis and ketolysis

Sphingolipid metabolism: integrated pathway

Eicosanoid metabolism via cyclooxygenases (COX)

Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

Sphingolipid metabolism (integrated pathway)

Genes related to primary cilium development (based on CRISPR)

Alternative pathway of fetal androgen synthesis

Molybdenum cofactor (Moco) biosynthesis

Cysteine and methionine catabolism

Bile acid synthesis and enterohepatic circulation

Omega-9 fatty acid synthesis

Omega-3 / omega-6 fatty acid synthesis

Eicosanoid metabolism via lipoxygenases (LOX)

Mitochondrial fission and fusion

Methionine metabolism leading to sulfur amino acids and related disorders

MTHFR deficiency

Degradation pathway of sphingolipids, including diseases

Wnt signaling in kidney disease

PI3K/AKT/mTOR - vitamin D3 signaling

PPAR signaling

Oxidative damage response

miR-222 in exercise-induced cardiac growth

Leptin-insulin signaling overlap

Kennedy pathway from sphingolipids

Embryonic stem cell pluripotency pathways

BMP signaling in eyelid development

Amino acid metabolism

Angiopoietin-like protein 8 regulatory pathway

Physico-chemical features and toxicity-associated pathways

Mitochondrial long chain fatty acid beta-oxidation

BDNF-TrkB signaling

Interactions between LOXL4 and oxidative stress pathway

Hypothesized pathways in pathogenesis of cardiovascular disease

Hematopoietic stem cell gene regulation by GABP alpha/beta complex

Lipid particles composition

Circadian rhythm genes

Fatty acid beta-oxidation (streamlined)

MECP2 and associated Rett syndrome

Methionine de novo and salvage pathway

Fatty acid biosynthesis

NOTCH1 regulation of endothelial cell calcification

Melatonin metabolism and effects

Copper homeostasis

Fluoropyrimidine activity

Codeine and morphine metabolism

Nicotine activity on chromaffin cells

Hair follicle development: cytodifferentiation - stage 3 of 3

Mammary gland development: embryonic development - stage 1 of 4

Oncostatin M signaling

Alzheimer's disease and miRNA effects

EPO receptor signaling

Omega-6-fatty acids in senescence

Aerobic glycolysis - augmented

Urea cycle and related diseases

Neural crest cell migration during development

Synaptic signaling associated with autism spectrum disorder

Parkin-ubiquitin proteasomal system pathway

TNF-related weak inducer of apoptosis (TWEAK) signaling

Effects of nitric oxide

Nucleotide excision repair in xeroderma pigmentosum

Meta pathway lipodystrophy, dyslipidemia and hyperlipidemia

Vasopressin-regulated water reabsorption

Response to acute ibuprofen exposure

Soluble ACE2-mediated cell entry of SARS-CoV-2

Modulators of TCR signaling and T cell activation

Phosphoinositides metabolism

Galanin receptor pathway

RAS and bradykinin pathways in COVID-19

Airway smooth muscle cell contraction

Mitochondrial complex I inhibition leading to parkinsonian motor deficits

Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition

TWEAK signaling pathway

Oxytocin signaling

Effects of nitric oxide

Pregnane X receptor pathway

Ectoderm differentiation

Mesodermal commitment pathway

Dopaminergic neurogenesis

Gene regulatory network modeling somitogenesis

Endoderm differentiation

Hair follicle development: organogenesis - stage 2 of 3

Selenium metabolism and selenoproteins

Nanoparticle-mediated activation of receptor signaling

Interleukin-1 (IL-1) structural pathway

Common pathways underlying drug addiction

Chicken limb development

Aryl hydrocarbon receptor pathway

Polycystic kidney disease pathway

HIF1A and PPARG in hypertrophic cardiomyopathy

TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)

Amyotrophic lateral sclerosis (ALS)

Spinal cord injury

Cardiac progenitor differentiation

Brain-derived neurotrophic factor (BDNF) signaling

Histone modifications

Gastric cancer network 2

Gastric cancer network 1

Adipogenesis

Corticotropin-releasing hormone signaling

miRNA biogenesis

AGE/RAGE pathway

Glial cell differentiation

Pathogenic Escherichia coli infection

Synaptic vesicle pathway

Glioblastoma signaling

Targeted therapy in breast cancer

Inhibition of GNAQ-regulated signaling in uveal melanoma

ID signaling

ROS in COVID-19 endothelial dysfunction

Targeted agents in triple negative breast cancer

Disorders in ketolysis

Vitamin K metabolism and activation of dependent proteins

Disorders in ketone body synthesis

N-glycan biosynthesis

Iron-sulfur cluster biogenesis

Sialylation

Glycolysis and gluconeogenesis

Glycogen synthesis and degradation

Metabolic pathway of LDL, HDL and TG, including diseases

Platelet-mediated interactions with vascular and circulating cells

Eicosanoid metabolism via cyclooxygenases (COX)

Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

Glycerolipids and glycerophospholipids

Sphingolipid metabolism overview

Wnt signaling and pluripotency

Metabolism of dichloroethylene by CYP450

Pathways affected in adenoid cystic carcinoma

NAD+ metabolism

Parkinson's disease

Insulin signaling in adipocytes (normal condition)

NAD metabolism, sirtuins and aging

AtMetExpress overview

Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling

Pre-implantation embryo

Osteoblast signaling

SREBP signaling

Interleukin-11 signaling pathway

UDP-L-arabinose biosynthesis I from UDP-xylose

TCA cycle (plant)

miRNA targets in ECM and membrane receptors

Farnesoid X receptor pathway

PPAR-alpha pathway

Vitamin D receptor pathway

Constitutive androstane receptor pathway

Liver X receptor pathway

Aryl hydrocarbon receptor pathway

Cardiac hypertrophic response

Pilocytic astrocytoma

Metastatic brain tumor

Thymic stromal lymphopoietin (TSLP) signaling

IL9 signaling

Endothelin pathways

Arrhythmogenic right ventricular cardiomyopathy

Type III interferon signaling

Neural crest differentiation

IL7 signaling

Microtubule cytoskeleton regulation

Prolactin signaling

Wnt signaling pathway

Isoglobo series sphingolipids

Mitochondrial fatty acid oxidation disorders

SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation

Eicosanoid lipid synthesis map

Mitochondrial complex I assembly model OXPHOS system

Fibrin complement receptor 3 signaling

Pyrimidine metabolism

Liver steatosis adverse outcome pathway

NO/cGMP/PKG mediated neuroprotection

Prader-Willi and Angelman syndrome

Prion disease pathway

Lipid metabolism pathway

IL4 signaling

Serotonin and anxiety

Serotonin and anxiety-related events

ROBO4 and VEGF signaling crosstalk

NAD+ biosynthetic pathways

PDGF pathway

Seed development

Histidine biosynthesis

Alzheimer's disease

COVID-19, thrombosis and anticoagulation

Hedgehog signaling

Vitamin B12 disorders

Disorders of folate metabolism and transport

Type 2 papillary renal cell carcinoma

Krebs cycle disorders

PI3K-Akt signaling

GABA metabolism (aka GHB)

Vitamin B12 metabolism

Nuclear receptors in lipid metabolism and toxicity

IL3 signaling

Ebstein-Barr virus LMP1 signaling

S1P receptor signal transduction

TNF-alpha signaling

Notch signaling pathway

Follicle stimulating hormone (FSH) signaling

Leptin signaling

Thyroid stimulating hormone (TSH) signaling

Cell differentiation - index

Cell differentiation - expanded index

RANKL/RANK signaling

SREBF and miR33 in cholesterol and lipid homeostasis

Integrated breast cancer pathway

Sterol regulatory element-binding proteins (SREBP) signaling

Cori cycle

Eicosanoid synthesis

Biotin metabolism

Nicotine effect on dopaminergic neurons

Glycogen metabolism

Heart development

Type II diabetes mellitus

Transcription factors regulate miRNAs related to cardiac hypertrophy

MicroRNAs in cardiomyocyte hypertrophy

Vitamin B12 metabolism

Vitamin D metabolism

Glucuronidation

Estrogen metabolism

Arylamine metabolism

Sulfation biotransformation reaction

T-cell receptor signaling

Oxidative phosphorylation

Disorders of mitochondrial homeostatis, dynamics, protein import, and quality control

T cell modulation and desmoplasia in pancreatic cancer

MYD88 distinct input-output pathway

BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation

Apoptosis modulation by HSP70

Striated muscle contraction pathway

Renin-angiotensin system

Wnt signaling pathway

Prostaglandin synthesis and regulation

EGF/EGFR signaling pathway

Notch signaling pathway

FAS pathway and stress induction of HSP regulation

Wnt signaling pathway

Glycogen metabolism

Notch signaling pathway

FAS pathway and stress induction of HSP regulation

Wnt signaling pathway

Toll-like receptor signaling

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF/GATA4 signaling

Monoamine transport

DNA damage response

Sudden infant death syndrome (SIDS) susceptibility pathways

Methylation pathways

Asparagine biosynthesis

Type II interferon signaling

Notch signaling

Monoamine GPCRs

FAS pathway and stress induction of HSP regulation

IL-2 signaling pathway

TGF-beta receptor signaling

Complement and coagulation cascades

ACE inhibitor pathway

Vedolizumab therapy for inflammatory bowel disease

Biogenic amine synthesis

Complement and coagulation cascades

Complement activation

Cancer pathways

Pancreatic cancer subtypes

Growth factors and hormones in beta cell proliferation

Glycolysis and gluconeogenesis

Cytokines and inflammatory response

Cell interactions in pancreatic cancer microenvironment

2q37 copy number variation syndrome

Glucose metabolism in triple-negative breast cancer cells

Exercise and hypertrophy in skeletal muscle

Urotensin-II-mediated signaling

SARS-CoV-2 replication organelle formation

Familial partial lipodystrophy

Regulation of actin cytoskeleton

Pleural mesothelioma

Steroid biosynthesis

IL2 signaling

Amino acid metabolism pathway excerpt: histidine catabolism extension

Purine metabolism and related disorders

Immune response to tuberculosis

Mevalonate arm of cholesterol biosynthesis pathway with inhibitors

Wnt signaling pathway

Ovarian infertility

Kit receptor signaling

Peptide GPCRs

B cell receptor signaling

Fatty acid omega-oxidation

miRNA regulation of DNA damage response

Physiological and pathological hypertrophy of the heart

Osteopontin signaling

Nucleotide-binding oligomerization domain (NOD) pathway

Bone morphogenic protein signaling and regulation

AMP-activated protein kinase signaling

Monoamine GPCRs

Glycogen metabolism

Wnt signaling pathway

Notch signaling pathway

Glycogen metabolism

Notch signaling pathway

FAS pathway and stress induction of HSP regulation

Wnt signaling pathway

IL-2 signaling pathway

Cell cycle

Irinotecan pathway

Glycogen metabolism

Translation factors

Notch signaling pathway

IL-4 signaling pathway

TGF-beta receptor signaling

TNF-alpha signaling pathway

Statin pathway

IL-3 signaling pathway

Notch signaling pathway

SARS-CoV-2 and ACE2 receptor: molecular mechanisms

Insulin signaling

Cytoplasmic ribosomal proteins

Endochondral ossification

Sphingolipid metabolism overview

Omega-9 fatty acid synthesis

Omega-3 / omega-6 fatty acid synthesis

Glycerolipids and glycerophospholipids

Eicosanoid metabolism via lipooxygenases (LOX)

Melanoma

Hepatitis B infection

Measles virus infection

Urea cycle and associated pathways

Cancer immunotherapy by PD-1 blockade

Cancer immunotherapy by CTLA4 blockade

Translation inhibitors in chronically activated PDGFRA cells

Neural crest cell migration in cancer

MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Interactions between immune cells and microRNAs in tumor microenvironment

FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma

GPCRs, class A rhodopsin-like

Inflammatory response pathway

IL-2 signaling pathway

G1 to S cell cycle control

Modified nucleosides derived from tRNA as urinary cancer markers

Altered glycosylation of MUC1 in tumor microenvironment

MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors

EGF/EGFR signaling

Glycogen metabolism

Statin inhibition of cholesterol production

Oxidation by cytochrome P450

Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer

Pancreatic adenocarcinoma pathway

Breast cancer pathway

Hedgehog signaling

Ras signaling

MAPK cascade

Somatroph axis (GH) and its relationship to dietary restriction and aging

Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine

Endometrial cancer

mRNA processing

Exercise-induced circadian regulation

Wnt signaling

p38 MAPK signaling

miRNA regulation of p53 pathway in prostate cancer

H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer

TYROBP causal network in microglia

Microglia pathogen phagocytosis pathway

Focal adhesion: PI3K-Akt-mTOR-signaling

Chemokine signaling

ApoE and miR-146 in inflammation and atherosclerosis

Development of pulmonary dendritic cells and macrophage subsets

Canonical and non-canonical TGF-B signaling

Apoptosis regulation by parathyroid hormone-related protein

Valproic acid pathway

Novel intracellular components of RIG-I-like receptor pathway

TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition

Toll-like receptor signaling related to MyD88

ERK pathway in Huntington's disease

TLR4 signaling and tolerance

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

MAPK and NFkB signaling inhibited by Yersinia YopJ

PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer

MAPK signaling

Amplification and expansion of oncogenic pathways as metastatic traits

lncRNA-mediated mechanisms of therapeutic resistance

Regulation of Wnt / B-catenin signaling by small molecule compounds

Wnt/beta-catenin signaling in leukemia

Hepatitis C and hepatocellular carcinoma

Imatinib and chronic myeloid leukemia

IL6 signaling

Gut-liver indole metabolism

Photodynamic therapy-induced NF-kB survival signaling

Photodynamic therapy-induced HIF-1 survival signaling

MicroRNA for targeting cancer growth and vascularization in glioblastoma

RAC1/PAK1/p38/MMP2 pathway

EV release from cardiac cells and their functional effects

TSLP signaling pathway

Nicotine activity on dopaminergic neurons

Glycogen metabolism

Fas ligand pathway and stress induction of heat shock proteins

Hepatocyte growth factor receptor signaling

AGE/RAGE pathway

Cori cycle

Focal adhesion

Myometrial relaxation and contraction pathways

Extracellular vesicle-mediated signaling in recipient cells

TCA cycle nutrient use and invasiveness of ovarian cancer

Bladder cancer

Mammary gland development: involution - stage 4 of 4

Notch signaling

T cell receptor and co-stimulatory signaling

Apoptosis

Trans-sulfuration, one-carbon metabolism and related pathways

Small ligand GPCRs

Retinoblastoma gene in cancer

Irinotecan pathway

IL17 signaling

Integrated cancer pathway

IL1 signaling

Proteasome degradation

Cell cycle

Apoptosis modulation and signaling

One-carbon metabolism and related pathways

Folate metabolism

TP53 network

Small ligand GPCRs

Fluoropyrimidine activity

Glycolysis and gluconeogenesis

Biogenic amine synthesis

Angiogenesis

Selenium micronutrient network

Target of rapamycin signaling

Statin pathway

Fatty acid beta-oxidation

Androgen receptor signaling

Phase I biotransformations, non-P450

Pentose phosphate metabolism

GPCRs, other

TGF-beta signaling pathway

Glycolysis and gluconeogenesis

B cell receptor signaling pathway

Hedgehog signaling pathway

FAS pathway and stress induction of HSP regulation

Wnt signaling pathway

IL-7 signaling pathway

TCR signaling pathway

TCA cycle

EPO receptor signaling

IL-9 signaling pathway

IL-2 signaling pathway

Eicosanoid synthesis

Small ligand GPCRs

Wnt signaling pathway

IL-5 signaling pathway

Glycogen metabolism

Cholesterol biosynthesis

Nuclear receptors

Pyrimidine ribonucleotide salvage pathways

Eukaryotic transcription initiation

G13 signaling pathway

Matrix metalloproteinases

G protein signaling pathways

Calcium regulation in cardiac cells

Ketone bodies synthesis and degradation

Blood clotting cascade

EPO receptor signaling

Eicosanoid synthesis

Cholesterol biosynthesis

Nuclear receptors

Eukaryotic transcription initiation

G13 signaling pathway

Matrix metalloproteinases

G protein signaling pathways

Calcium regulation in cardiac cells

Ketone bodies synthesis and degradation

TCA cycle (aka Krebs or citric acid cycle)

Blood clotting cascade

EPO receptor signaling

Glutathione and one-carbon metabolism

G protein signaling pathways

DNA damage response (only ATM dependent)

Aflatoxin B1 metabolism

ErbB signaling

Integrin-mediated cell adhesion

Interferon type I signaling

Eukaryotic transcription initiation

Calcium regulation in cardiac cells

Synthesis and degradation of ketone bodies

Calcium regulation in cardiac cells

DNA mismatch repair

G13 signaling

G13 signaling pathway

Eukaryotic transcription initiation

Endochondral ossification with skeletal dysplasias

Blood clotting cascade

Oxidative stress and redox pathway

Matrix metalloproteinases

TCA cycle

ncRNAs in Wnt signaling in hepatocellular carcinoma

Ketone bodies synthesis and degradation

lncRNA in canonical Wnt signaling and colorectal cancer

Eukaryotic transcription initiation

Epithelial to mesenchymal transition in colorectal cancer

Chromosomal and microsatellite instability in colorectal cancer

MET in type 1 papillary renal cell carcinoma

Oxidative stress response

Oxidative stress response

Eukaryotic transcription initiation

Clear cell renal cell carcinoma pathways

G protein signaling

Synthesis and degradation of ketone bodies

Blood clotting cascade

Eicosanoid synthesis

Transcriptional activation by NRF2 in response to phytochemicals

G13 signaling pathway

Electron transport chain

Mammary gland development: puberty - stage 2 of 4

Matrix metalloproteinases

Blood clotting cascade

G protein signaling pathways

Nuclear receptors

Homologous recombination

Integrin-mediated cell adhesion

Eukaryotic transcription initiation

Oxidative stress response

Nuclear receptors

Energy metabolism

Cholesterol biosynthesis

Oxidative stress response

Electron transport chain

EPO receptor signaling

Eicosanoid synthesis

EPO receptor signaling

EPO receptor signaling

Eukaryotic transcription initiation

TCA cycle

Homologous recombination

Cholesterol biosynthesis

Nuclear receptors

Eukaryotic transcription initiation

G13 signaling pathway

Matrix metalloproteinases

G protein signaling pathways

Calcium regulation in cardiac cells

Ketone bodies synthesis and degradation

Blood clotting cascade

Electron transport chain

EPO receptor signaling

Electron transport chain: OXPHOS system in mitochondria

Eicosanoid synthesis

Cholesterol biosynthesis

Integrin-mediated cell adhesion

Nuclear receptors

Eukaryotic transcription initiation

G13 signaling pathway

Matrix metalloproteinases

Oxidative stress response

G protein signaling pathways

Calcium regulation in cardiac cell

Homologous recombination

Cholesterol biosynthesis

Ketone bodies synthesis and degradation

Synthesis and degradation of ketone bodies

Electron transport chain

Transcriptional regulation of memory B cell differentiation

HDAC6 interactions in the central nervous system

IL11 signaling

Allograft rejection

Matrix metalloproteinases

Hypothetical network for drug addiction

Transcriptional activation by Nfe2l2 in response to phytochemicals

IL5 signaling

Transcriptional activation by Nfe2l2 in response to phytochemicals

Irinotecan pathway

Osteoclast signaling

Immune infiltration in pancreatic cancer

Familial hyperlipidemia type 2

Folate-alcohol and cancer pathway hypotheses

miRNA regulation of prostate cancer signaling

Deregulation of Rab and Rab effector genes in bladder cancer

DNAJB1-PRKACA fusion in fibrolamellar liver cancer

Neolacto series sphingolipid metabolism

Non-classical role of vitamin D

Vitamin D-sensitive calcium signaling in depression

Vitamin D in inflammatory diseases

Vitamins A and D - action mechanisms

Lactate shuttle in glial cells

Disorders of galactose metabolism

IL10 anti-inflammatory signaling

Albuterol and budesonide therapy for asthma

Oxidative stress in pulmonary tissue

IL26 signaling

Glycosylation and related congenital defects

Nucleotide excision repair

Serine biosynthesis

Fatty acid biosynthesis, initial steps

Nicotine metabolism in liver cells

Markers of kidney cell lineage

Development of ureteric derived collecting system

GDNF/RET signaling axis

Fatty acid and lipoprotein transport in hepatocytes

NSAIDs mechanism of action

Affected pathways in Duchenne muscular dystrophy

Acute viral myocarditis

Direct reversal repair

Base excision repair

Glyoxylate metabolism

Copper metabolism

NAD salvage pathway V

Octadecanoid formation from linoleic acid

GIP and GLP-1 function by tissue

Omega-3-fatty acids in senescence

Mitochondrial carrier deficiency associated with shuttle disturbances

Joubert syndrome

nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell

SCFA and skeletal muscle substrate metabolism

Amino acid metabolism

Pathways of nucleic acid metabolism and innate immune sensing

Somatic sex determination

Photodynamic therapy-induced AP-1 survival signaling

GNAQ p.R183Q drives capillary malformation

Superpathway polyamine biosynthesis

Superpathway of serine and glycine biosynthesis

Serotonin HTR1 group and FOS pathway

Bempedoic acid therapy in atherosclerosis and metabolic syndrome

Leucine degradation

Leucine biosynthesis

Glutamate degradation IX

Sphingolipid biosynthesis

Glutathione biosynthesis

Cysteine biosynthesis from homoserine

Pentose phosphate pathway

Phospholipid biosynthesis

Salvage pathways of pyrimidine deoxyribonucleotides

Pentose pathway, non-oxidative branch

Na/K-ATPase/Src signaling

Regulation of immune response in the intestine

Hepatocyte growth factor receptor signaling

Dopaminergic neurogenesis

Hunger and satiety

MAP3K1 role in promoting and blocking gonadal determination

Mammalian disorder of sexual development

Thyroid hormones production and peripheral downstream signaling effects

Cyclin-dependent kinase 4/6 inhibitors in breast cancer

Tyrosine kinase inhibitors in glioblastoma

Targeting YAP in pancreatic ductal adenocarcinoma (PDAC)

Phosphoinositide 3-kinase (PI3K) family

Regulation of cytotoxic T cell responses by Malat1 - miR-15/16 circuit

Hallmark of cancer: non-mutational epigenetic reprogramming

Hallmark of cancer: sustaining proliferative signaling

Dravet syndrome

Hallmark of cancer: metastasis and epithelial-to-mesenchymal transition

Type I interferon induction and signaling during SARS-CoV-2 infection

Kallmann syndrome

NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

miR-targeted genes in squamous cell

miR-targeted genes in muscle cell

miR-targeted genes in lymphocytes

miR-targeted genes in leukocytes

miR-targeted genes in adipocytes

TCA cycle - detailed

Tyrosine biosynthesis

Pantothenate and coenzyme A biosynthesis

MAPK signaling pathway

Phosphatidic acid and phospholipid biosynthesis

Threonine and methionine biosynthesis

Threonine biosynthesis

Glutamate biosynthesis superpathway

Superpathway of branched chain amino acid biosynthesis

Histidine, purine, and pyrimidine superpathway

Isoleucine biosynthesis

PCSK9-mediated LDL receptor degradation

Triglyceride biosynthesis

Isoleucine degradation

Arachidonic acid (AA, ARA) oxylipin metabolism

Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids

Gastrin signaling

Pyruvate dehydrogenase pathway

Dauer formation

Mitochondrial unfolded-protein response

Programmed cell death

Wnt signaling - Q neuroblast migration

ER stress-unfolded protein response (UPRer)

Programmed cell death and cell engulfment

Left-right asymmetry in the nervous system

Ascaroside biosynthesis

Wnt signaling in cell polarity

EGF signaling in vulval development

Notch signaling in vulval development

Cell division: first embryonic mitosis

Biogenic amine synthesis

Vulval development and SynMuv

Role of lipid metabolism

Programmed cell death and cell engulfment

Wnt signaling

Metapathway signal transduction

Glucocorticoid effect on target gene expression

Acute myeloid leukemia

Principal pathways of carbon metabolism

JAK-STAT signaling in the regulation of beta cells

Cholesterol metabolism

COVID-19 adverse outcome pathway

Cholesterol biosynthesis pathway in hepatocytes

Arsenic metabolism and reactive oxygen species generation

Clock-controlled autophagy in bone metabolism

DNA IR-double strand breaks and cellular response via ATM

Lysine biosynthesis

T-cell activation SARS-CoV-2

Orexin receptor pathway

Neuroinflammation and glutamatergic signaling

Burn wound healing

Osteoarthritic chondrocyte hypertrophy

Estradiol regulation in porto-sinusoidal vascular disease

Nonalcoholic fatty liver disease

Glucocorticoid receptor pathway

3q29 copy number variation syndrome

Endoplasmic reticulum stress response in coronavirus infection

Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex

Neovascularization processes

Tamoxifen metabolism

UDP-glucose conversion

Selenium metabolism / selenoproteins

Vitamin A1 and A5/X pathways

GPR143 in melanocytes and retinal pigment epithelium cells

LTF danger signal response pathway

Non-genomic actions of 1,25-dihydroxyvitamin D3

LDL- influence on CD14 and TLR4

GNAQ pathways in port-wine stain

Macrophage-stimulating protein (MSP) signaling

Activation of NLRP3 inflammasome by SARS-CoV-2

Renin-angiotensin-aldosterone system (RAAS)

MAPK pathway in congenital thyroid cancer

MicroRNA network associated with chronic lymphocytic leukemia

NRF2-ARE regulation

Ciliary landscape

ncRNAs involved in STAT3 signaling in hepatocellular carcinoma

Thermogenesis

Mitochondrial fatty acid synthesis pathway

Malate-aspartate shuttle

FGFR4 p.G388R signaling

Estrogen metabolism

Synthesis of ceramides and 1-deoxyceramides

Biosynthesis and turnover of 1-deoxy-sphingoid bases

Docosahexaenoic acid oxylipin metabolism

Lipid metabolism in senescent cells

Interactions of natural killer cells in pancreatic cancer

Fluoroacetic acid toxicity

16p11.2 proximal deletion syndrome

Major receptors targeted by epinephrine and norepinephrine

Metabolism of alpha-linolenic acid

Blood clotting and drug effects

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Intraflagellar transport proteins binding to dynein

Signal transduction through IL1R

Ophthalmate biosynthesis in hepatocytes

Control of immune tolerance by vasoactive intestinal peptide

Relationship between inflammation, COX-2 and EGFR

Pathophysiological roles of DUX4 in FSHD1

Th17 cell differentiation pathway

Network map of SARS-CoV-2 signaling

Proximal tubule transport

SARS coronavirus and innate immunity

Purinergic signaling

NPHP1 deletion syndrome

TAR syndrome

Kleefstra syndrome

Female steroid hormones in cardiomyocyte energy metabolism

2q13 copy number variation syndrome

DYRK1A involvement regarding cell proliferation in brain development

15q13.3 copy number variation syndrome

15q11.2 copy number variation syndrome

7q11.23 copy number variation syndrome

Unfolded protein response

1q21.1 copy number variation syndrome

Peroxiredoxin 2 induced ovarian failure

Regucalcin in proximal tubule epithelial kidney cells

8q11.23 (RB1CC1) copy number variation

15q25 copy number variation

15q11q13 copy number variation

13q12.12 copy number variation

10q22q23 copy number variation

5q35 copy number variation

17p13.3 (YWHAE) copy number variation

4p16.3 copy number variation

17q12 copy number variation syndrome

Glucocorticoid biosynthesis

Mineralocorticoid biosynthesis

Farnesyl to CoQ10 metabolism

Neurogenesis regulation in the olfactory epithelium

Cholestasis

Bardet-Biedl syndrome

Hippocampal synaptogenesis and neurogenesis

Nephrotoxcicity adverse outcome pathway

Thyroid hormone imbalance leading to neurodevelopmental abnormalities

2q21.1 copy number variation syndrome

2q11.2 copy number variation syndrome

Metabolic reprogramming in pancreatic cancer

Amino acid metabolism in triple-negative breast cancer cells

SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Roles of ceramides in development of insulin resistance

Disorders of fructose metabolism

Spina bifida

ALA oxylipin metabolism

Familial hyperlipidemia type 5

Familial hyperlipidemia type 4

Familial hyperlipidemia type 1

Fatty acid transporters

Nephrogenesis

ACE2 inhibition leads to pulmonary fibrosis

Genes associated with the development of rheumatoid arthritis

p53 transcriptional gene network

Mitochondrial long chain fatty acid beta-oxidation

EBV LMP1 signaling

Amino acid conjugation

Arachidonate epoxygenase / epoxide hydrolase

Exercise-induced circadian regulation

Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

Phosphatidyl inositol phosphate pathway

PAFAH1B1 copy number variation

13q12 or CRYL1 copy number variation

7q11.23 distal copy number variation

6q16 copy number variation

NRXN1 deletion syndrome

Glycosaminoglycan synthesis in fibroblasts

UDP-derived sugars synthesis in fibroblasts

DNA adduct formation leading to kidney failure

Smith-Magenis and Potocki-Lupski syndrome copy number variation

Sulfatase and aromatase pathway

NF1 copy number variation syndrome

8p23.1 copy number variation syndrome

1p36 copy number variation syndrome

Autophagy in pancreatic ductal adenocarcinoma

Prostaglandin and leukotriene metabolism in senescence

Male steroid hormones in cardiomyocyte energy metabolism

Sebaleic acid formation and metabolism

Lacto series sphingolipid metabolism

Ganglio series sphingolipid metabolism

Sildenafil treatment

Glycosphingolipid metabolism

Complement system in neuronal development and plasticity

Burn wound healing

Burn wound healing

Kynurenine pathway and links to cell senescence

Pentose phosphate pathway in senescent cells

SARS-CoV-2 innate immunity evasion and cell-specific immune response

TCA cycle

Overlap between signal transduction pathways contributing to LMNA laminopathies

Hijack of ubiquitination by SARS-CoV-2

Influence of laminopathies on Wnt signaling

Mitochondrial gene expression

Triacylglyceride synthesis

ESC pluripotency pathways

Post-COVID neuroinflammation

Catabolism of skeletal muscle in cachexia

FOXP3 in COVID-19

Mitochondrial immune response to SARS-CoV-2

Aspirin and miRNAs

Biotic stress response gene network

Rett syndrome

Flavan-3-ol metabolic pathway

Ebola virus infection in host

Dengue-2 interactions with complement and coagulation cascades

Nanomaterial-induced inflammasome activation

Zinc homeostasis

Folate metabolism

Endothelin pathways

Differentiation pathway

Quercetin and Nf-kB / AP-1 induced cell apoptosis

Mitochondrial gene expression

Monoamine transport

Quercetin and Nf-kB / AP-1 induced apoptosis

TROP2 regulatory signaling

ApoE and miR-146 in inflammation and atherosclerosis

Seed development

Oxylipins pathways

Familial hyperlipidemia type 3

Folic acid network

Nod-like receptor (NLR) signaling pathway

Folic acid network

Mitochondrial gene expression

Nod-like receptor (NLR) signaling pathway

Arachidonate epoxygenase / epoxide hydrolase

Heme biosynthesis

Heme biosynthesis

Complement and coagulation cascades

Nod-like receptor (NLR) signaling pathway

Arachidonate epoxygenase / epoxide hydrolase

FTO obesity variant mechanism

Sulfur amino acid biosynthesis

Sucrose biosynthesis

Frustrated phagocytosis leading to malignant pleural mesothelioma

Cytokine-cytokine receptor interaction

Axon guidance

Inflammatory bowel disease signaling

Receptor tyrosine kinase (RTK) family

Artemisinin inhibition of uveal melanoma

Hippo signaling regulation

FLT3 p.Gln640SerfsTer8 signaling

IL19 signaling

TGFB / Smad signaling

Cardiomyocyte signaling converging on titin

Induction of autophagy and toll-like receptor signaling by graphene oxide

NRP1-triggered signaling in pancreatic cancer

CCL18 signaling

IL18 signaling

Netrin-UNC5B signaling

Interferon-mediated signaling

Regulatory circuits of STAT3 signaling

Equilibrium signaling of differentiated cells

Nod-like receptor (NLR) signaling

Alpha 6 beta 4 signaling

Resolvin E1 and resolvin D1 signaling decrease inflammation

Triacylglyceride synthesis

Involvement of δ-secretase in neurodegenerative diseases

Enterocyte cholesterol metabolism

Metabolism of T-2 toxin and HT-2 toxin

Metabolic epileptic disorders

Effects of MFN2 mutation

Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins

Arsenic liver toxicity pathway

Ulcerative colitis signaling

Type I collagen synthesis in the context of osteogenesis imperfecta

Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Biosynthesis of the three types of mycolic acids

Estrogen receptor pathway

Rubinstein-Taybi syndrome 1

NIPBL role in DNA damage - Cornelia de Lange syndrome

SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Cohesin complex - Cornelia de Lange syndrome

Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome

Wnt signaling in kidney disease

Mecp2 and associated Rett syndrome

Hypothetical craniofacial development pathway

Ectodysplasin A signaling in hair follicle development

Wnt myofibroblastic activation of hepatic stellate cells

GLP-1 secretion from intestine to portal vein

Extrafollicular and follicular B cell activation by SARS-CoV-2

Heme biosynthesis

GLP-1 from intestine and pancreas and role in glucose homeostasis

GLP-1 in pancreatic islet cells

mRNA vaccine activation of dendritic cell and induction of IFN-1

Selective expression of chemokine receptors during T-cell polarization

Suppression of HMGB1-mediated inflammation by THBD

Ethanol metabolism production of ROS by CYP2E1

Poly(glycerol phosphate) wall teichoic acid biosynthesis

Intracellular auxin transport

Hematopoietic stem cell differentiation

Mitochondrial complex inhibition leading to liver injury

Secretion of hydrochloric acid in parietal cells

Gastric acid production

Kinin-Kallikrein pathway

Acetaminophen in analgesia and antipyresis

Downregulation of ACE2 by SARS-CoV-2 spike protein

Ciliopathies

Alstrom syndrome

Effect of progerin on genes involved in progeria

Lamin A processing pathway

p53 pathway

10q11.21q11.23 copy number variation syndrome

Hypoxia-dependent differentiation of myoblasts

Hypoxia-dependent self-renewal of myoblasts

Kisspeptin/kisspeptin receptor system in the ovary

22q11.2 copy number variation syndrome

FABP4 in ovarian cancer

miRNA role in immune response in sepsis

Dysregulated miRNA targeting in insulin/PI3K-AKT signaling

Cell-type dependent selectivity of CCK2R signaling

Angiogenesis

SIDS susceptibility pathways

Hypoxia-mediated EMT and stemness

Focal adhesion: PI3K-Akt-mTOR signaling pathway

N-glycan biosynthesis

Overview of proinflammatory and profibrotic mediators

Flowering time pathway

Flowering time pathway

Thyroxine (thyroid hormone) production

TCA cycle

Host-pathogen interaction of human coronaviruses - interferon induction

Drug induction of bile acid pathway

Drug induction of bile acid pathway

Angiotensin II receptor type 1 pathway

Evolocumab mechanism to reduce LDL cholesterol

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression

7-oxo-C and 7-beta-HC pathways

Amino acid transport defects (IEMs)

Enterohepatic circulation of bile acids

Steroid hormone precursor biosynthesis

Oxysterols derived from cholesterol

Riboflavin and CoQ disorders

Linoleic acid metabolism affected by SARS-CoV-2

Vitamin B6-dependent and responsive disorders

Neurotransmitter disorders

Metabolism of sphingolipids in ER and Golgi apparatus

Cell lineage map for neuronal differentiation

Genetic causes of porto-sinusoidal vascular disease

Acquired partial lipodystrophy / Barraquer-Simons syndrome

Burn wound healing

16p11.2 distal deletion syndrome

Cellular proteostasis

Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway

EPAC1 and PKA reduction of retinal inflammation

Chronic hyperglycemia impairment of neuron function

Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway)

Lung pathology of COVID-19

COVID-19 structural coverage map

OSX and miRNAs in tooth development

Disorders of bile acid synthesis and biliary transport

Iron metabolism disorders

Hemesynthesis defects and porphyrias

Ethylmalonic encephalopathy

Leucine, isoleucine and valine metabolism

Hippo-Merlin signaling dysregulation

Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases

Pyrimidine metabolism and related diseases

Cholesterol synthesis disorders

Calcium mediated T-cell apoptosis involved in inclusion body myositis

Proline and hydroxyproline pathways

Tyrosine metabolism and related disorders

Codeine and morphine metabolism

Phase I biotransformations, non-P450

Phase I biotransformations, non-P450

Phase I biotransformations, non-P450

KCNQ2-related epilepsies

Acetylcholine synthesis

Focal adhesion

Nucleotide GPCRs

Tryptophan metabolism

Insulin signaling

Steroid biosynthesis

Prostaglandin signaling

GPCRs, class C metabotropic glutamate, pheromone

GPCRs, other

Inflammatory response pathway

IDO metabolic pathway

Fatty acid omega-oxidation

Translation factors

Notch signaling pathway

Fatty acid beta-oxidation 3

T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection

Glycine metabolism, including IMDs

Canonical and non-canonical Notch signaling

PGK1, PKM2, KHKC/KHKA acting as protein kinases

High-osmolarity glycerol (HOG) pathway

Non-canonical Wnt pathway

Sphingolipid metabolism in senescence

Glycolysis in senescence

Carnosine metabolism of glial cells

Wnt signaling pathway and pluripotency

Primary ovarian insufficiency

Hippo-YAP signaling

Warburg effect modulated by deubiquitinating enzymes and their substrates

D-arginine and D-ornithine metabolism

Diet-dependent trimethylamine/trimethylamine N-oxide metabolism

Osteoblast signaling

Nuclear receptors meta-pathway

Glycerophospholipid biosynthetic pathway

Comprehensive IL-17A signaling

VEGF-receptor signal transduction

Mechanisms associated with pluripotency

Iron homeostasis

Flavonoid biosynthesis

Regulation of cardiac hypertrophy by miR-208

Oxidative damage response

Opioid receptor pathways

Heart development

Photosynthetic carbon reduction

Serotonin transporter activity

VEGFA-VEGFR2 signaling

Response regulator aspartate phosphatase interactions

Glucose homeostasis

Abscisic acid biosynthesis

Flower development

Fructose metabolism in proximal tubules

Bacterial ceramide synthesis

Serotonin transporter activity

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF / GATA4 signaling

Serotonin receptor 2 and STAT3 signaling

Serotonin receptor 2 and STAT3 signaling

IL-9 signaling pathway

IL-6 signaling pathway

Meiotic recombination genes

Osteoclast signaling

GPCRs, class A rhodopsin-like

Retinol metabolism

Inclusion body myositis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Glycerophospholipid biosynthetic pathway

Wnt signaling pathway and pluripotency

ATM signaling pathway

Glycerol teichoic acid biosynthesis

PtdIns(4,5)P2 in cytokinesis pathway

Leukotriene metabolic pathway

GDNF/RET signaling axis

Metabolism of tetrahydrocannabinol (THC)

Primary focal segmental glomerulosclerosis (FSGS)

Cardiac progenitor differentiation

Primary carbon metabolism

Pentose phosphate pathway

Primary focal segmental glomerulosclerosis (FSGS)

Cardiolipin biosynthesis

DNA replication

Oxidation by cytochrome P450

Translation factors

Oxidation by cytochrome P450

Pentose phosphate pathway

Heme biosynthesis

TCA cycle in senescence

Deregulation of renin-angiotensin system by SARS-CoV infection

Fatty acid beta-oxidation 1

Heme biosynthesis

Fatty acid beta-oxidation

Triacylglyceride synthesis

Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists

COVID-19 and endothelial cell senescence

Mitochondrial beta-oxidation

Lac-Phe pathway

Myometrial relaxation and contraction pathways

Myometrial relaxation and contraction pathways

Myometrial relaxation and contraction pathways

Resistin as a regulator of inflammation

Overview of nanoparticle effects

Steroid biosynthesis

Retinoblastoma gene in cancer

Glycolysis and gluconeogenesis

Actin cytoskeleton regulation

Selenium micronutrient network

Selenium micronutrient network

Selenium micronutrient network

Cells and molecules involved in local acute inflammatory response

Regulation of actin cytoskeleton

ABA biosynthesis

ID signaling pathway

ID signaling pathway

DNA IR-damage and cellular response via ATR

ID signaling pathway

ID signaling pathway

GDNF signaling

LDLRAD4 and what we know about it

SARS-CoV-2 and COVID-19 pathway

BDNF pathway

MAPK signaling pathway

Triacylglyceride synthesis

Wnt signaling pathway and pluripotency

Serine metabolism

Long-day flowering time pathway

Spinal cord injury

Linoleic acid oxylipin metabolism

Beta-oxidation of unsaturated fatty acids

Trehalose degradation, low osmolarity

Male infertility

Nod-like receptor (NLR) signaling pathway

Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway

Role of carnosine in muscle contraction

Hormonal control of pubertal growth spurt

Host-pathogen interaction of human coronaviruses - MAPK signaling

Progeria-associated lipodystrophy

Congenital generalized lipodystrophy

Biotin metabolism, including IMDs

Hypoxia-dependent proliferation of myoblasts

Distal convoluted tubule 1 (DCT1) cell

Beta-oxidation of unsaturated fatty acids

Beta-oxidation meta-pathway

miR-222 in exercise-induced cardiac growth

Ovarian infertility

Fatty acid beta-oxidation meta-pathway

SARS-CoV-2 altering angiogenesis via NRP1

Flowering time pathway

Toll-like receptor signaling pathway

Hepatocyte growth factor receptor signaling

Hepatocyte growth factor receptor signaling

Hepatocyte growth factor receptor signaling

Cytokinin-auxin interactions in plant development

Polar auxin transport

Fatty acid beta-oxidation 3

Glucosinolate biosynthesis from branched-chain amino acid

Glucosinolate biosynthesis from methionine

Mitochondrial long chain fatty acid beta-oxidation

Nodal signaling pathway

Triacylglyceride synthesis

Fatty acid beta-oxidation 2

Proteasome degradation

ERK1-ERK2 MAPK cascade