Eweitz

Hepatitis B infection

H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer

Development and heterogeneity of the ILC family

PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer

Malate-aspartate shuttle

Involvement of δ-secretase in neurodegenerative diseases

Enterocyte cholesterol metabolism

Cholesterol metabolism

FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma

Synaptic signaling associated with autism spectrum disorder

Bile acid synthesis and enterohepatic circulation

Heart development

Statin pathway

Macrophage-stimulating protein (MSP) signaling

ROS in COVID-19 endothelial dysfunction

Vitamin B12 metabolism

Selenium metabolism and selenoproteins

One-carbon metabolism

Prion disease pathway

Metabolism of T-2 toxin and HT-2 toxin

Metabolic epileptic disorders

Effects of MFN2 mutation

Cancer pathways

ADHD and autism (ASD) pathways

Intracellular trafficking proteins involved in CMT neuropathy

Ovarian infertility

Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins

Aerobic glycolysis

Aerobic glycolysis - augmented

DNA replication

GNAQ pathways in port-wine stain

Fatty acids and lipoproteins transport in hepatocytes

Lactate shuttle in glial cells

Arsenic liver toxicity pathway

Ulcerative colitis signaling

SARS-CoV-2 replication organelle formation

Frustrated phagocytosis leading to malignant pleural mesothelioma

GPR143 in melanocytes and retinal pigment epithelium cells

Type I collagen synthesis in the context of osteogenesis imperfecta

Melanoma

Head and neck squamous cell carcinoma

Oligodendrocyte specification and differentiation, leading to myelin components for CNS

MET in type 1 papillary renal cell carcinoma

Biosynthesis of the three types of mycolic acids

Liver steatosis adverse outcome pathway

Development of pulmonary dendritic cells and macrophage subsets

Estrogen receptor pathway

Left-right asymmetry in the nervous system

Sudden infant death syndrome (SIDS) susceptibility pathways

Rubinstein-Taybi syndrome 1

Inflammatory bowel disease signaling

NRP1-triggered signaling pathways in pancreatic cancer

NIPBL role in DNA damage - Cornelia de Lange syndrome

SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Cohesin complex - Cornelia de Lange syndrome

STING pathway in Kawasaki-like disease and COVID-19

Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome

Modified nucleosides derived from tRNA as urinary cancer markers

Degradation pathway of sphingolipids, including diseases

Wnt signaling in kidney disease

Wnt signaling in kidney disease

MicroRNA for targeting cancer growth and vascularization in glioblastoma

Mecp2 and associated Rett syndrome

Hypothetical craniofacial development pathway

Ectodysplasin A signaling in hair follicle development

Wnt myofibroblastic activation of hepatic stellate cells

Interferon type I signaling pathways

Mitochondrial immune response to SARS-CoV-2

GLP-1 secretion from intestine to portal vein

Cytokines and inflammatory response

Extrafollicular and follicular B cell activation by SARS-CoV-2

Heme biosynthesis

GLP-1 from intestine and pancreas and role in glucose homeostasis

GLP-1 in pancreatic islet cells

Hunger and satiety

Cell interactions of the pancreatic cancer microenvironment

Markers of kidney cell lineage

mRNA vaccine activation of dendritic cell and induction of IFN-1

T-cell activation SARS-CoV-2

Measles virus infection

Selective expression of chemokine receptors during T-cell polarization

Altered glycosylation of MUC1 in tumor microenvironment

Suppression of HMGB1-mediated inflammation by THBD

LTF danger signal response pathway

Ethanol metabolism production of ROS by CYP2E1

Poly(glycerol phosphate) wall teichoic acid biosynthesis

Intracellular auxin transport

Hematopoietic stem cell differentiation

Glial cell differentiation

Dopaminergic neurogenesis

RAS and bradykinin pathways in COVID-19

Mitochondrial complex inhibition leading to liver injury

Secretion of hydrochloric acid in parietal cells

Gastric acid production

Kinin-Kallikrein pathway

Immune response to tuberculosis

Serotonin and anxiety

Serotonin and anxiety-related events

Dengue-2 interactions with complement and coagulation cascades

ERK pathway in Huntington's disease

Acetaminophen in analgesia and antipyresis

Downregulation of ACE2 by SARS-CoV-2 spike protein

Physiological and pathological hypertrophy of the heart

FLT3 p.Gln640SerfsTer8 signaling pathway

TCA cycle (aka Krebs or citric acid cycle)

Oxidative stress response

Wnt signaling pathway

ATM signaling in development and disease

Steroid biosynthesis

Hypothesized pathways in pathogenesis of cardiovascular disease

Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Ciliopathies

Metabolic pathway of LDL, HDL and TG, including diseases

Influence of laminopathies on Wnt signaling

TGF-beta receptor signaling in skeletal dysplasias

Endochondral ossification with skeletal dysplasias

FGF23 signaling in hypophosphatemic rickets and related disorders

Multiple epiphyseal dysplasia and pseudoachondroplasia genes

Autosomal recessive osteopetrosis pathways

Somitogenesis in the context of spondylocostal dysostosis

Proteoglycan biosynthesis

Endochondral ossification

Alstrom syndrome

Envelope proteins and their potential roles in EDMD physiopathology

Effect of progerin on genes involved in progeria

Lamin A processing pathway

Acute viral myocarditis

DNA damage response

p53 pathway

Osteoarthritic chondrocyte hypertrophy

10q11.21q11.23 copy number variation syndrome

Cardiomyocyte signaling pathways converging on titin

Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids

Hypoxia-dependent differentiation of myoblasts

Hypoxia-dependent self-renewal of myoblasts

Kisspeptin/kisspeptin receptor system in the ovary

PKC-gamma calcium signaling pathway in ataxia

Thyroid hormones production and peripheral downstream signaling effects

Pathways of nucleic acid metabolism and innate immune sensing

22q11.2 copy number variation syndrome

FABP4 in ovarian cancer

Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors

Neovascularization processes

miRNA role in immune response in sepsis

Type 2 papillary renal cell carcinoma

Epithelial to mesenchymal transition in colorectal cancer

PI3K-Akt signaling pathway

miRNA regulation of p53 pathway in prostate cancer

Dysregulated miRNA targeting in insulin/PI3K-AKT signaling

Cell-type dependent selectivity of CCK2R signaling

Photodynamic therapy-induced NF-kB survival signaling

Angiogenesis

SIDS susceptibility pathways

Hypoxia-mediated EMT and stemness

Focal adhesion: PI3K-Akt-mTOR signaling pathway

Effects of nitric oxide

Vitamin A and carotenoid metabolism

N-glycan biosynthesis

Overview of proinflammatory and profibrotic mediators

DNA replication

Flowering time pathway

Oxytocin signaling

Flowering time pathway

One-carbon metabolism

Thyroxine (thyroid hormone) production

TCA cycle

Estrogen signaling pathway

GABA receptor signaling

Mammary gland development pathway - Involution (Stage 4 of 4)

Mammary gland development pathway - Puberty (Stage 2 of 4)

Mammary gland development pathway - Embryonic development (Stage 1 of 4)

Host-pathogen interaction of human coronaviruses - interferon induction

Drug induction of bile acid pathway

T cell modulation in pancreatic cancer

Breast cancer pathway

Drug induction of bile acid pathway

TCA cycle nutrient use and invasiveness of ovarian cancer

Irinotecan pathway

Irinotecan pathway

Angiotensin II receptor type 1 pathway

Aspirin and miRNAs

Evolocumab mechanism to reduce LDL cholesterol

Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition

Polycystic kidney disease pathway

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression

ATR signaling

Regulation of apoptosis by parathyroid hormone-related protein

Striated muscle contraction pathway

Amplification and expansion of oncogenic pathways as metastatic traits

Vitamin D metabolism

Endometrial cancer

ACE inhibitor pathway

7-oxo-C and 7-beta-HC pathways

Amino acid transport defects (IEMs)

Alternative pathway of fetal androgen synthesis

Focal adhesion: PI3K-Akt-mTOR-signaling pathway

Angiogenesis

Enterohepatic circulation of bile acids

Steroid hormone precursor biosynthesis

Cholesterol biosynthesis with skeletal dysplasias

Oxysterols derived from cholesterol

Disorders of folate metabolism and transport

NAD metabolism, sirtuins and aging

Bladder cancer

Glioblastoma signaling pathways

Pilocytic astrocytoma

Artemisinin inhibition of uveal melanoma

Riboflavin and CoQ disorders

Linoleic acid metabolism affected by SARS-CoV-2

Vitamin B6-dependent and responsive disorders

Neurotransmitter disorders

Metabolism of sphingolipids in ER and Golgi apparatus

Cell lineage map for neuronal differentiation

Growth factors and hormones in beta cell proliferation

JAK-STAT signaling in the regulation of beta cells

Genetic causes of porto-sinusoidal vascular disease

Alzheimer's disease

Acquired partial lipodystrophy / Barraquer-Simons syndrome

Burn wound healing

16p11.2 distal deletion syndrome

Cellular proteostasis

Overlap between signal transduction pathways contributing to LMNA laminopathies

Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway

IL-10 anti-inflammatory signaling pathway

Rett syndrome

Wnt signaling pathway

Lipid metabolism pathway

FTO obesity variant mechanism

Gene regulatory network modeling somitogenesis

Histone modifications

Biotin metabolism

Type II diabetes mellitus

EPAC1 and PKA reduction of retinal inflammation

Sphingolipid metabolism overview

Chronic hyperglycemia impairment of neuron function

Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway)

Lung pathology of COVID-19

COVID-19 structural coverage map

OSX and miRNAs in tooth development

miRNA targets in ECM and membrane receptors

Parkinson's disease pathway

Immune infiltration in pancreatic cancer

Ether lipid biosynthesis

Disorders in ketolysis

Creatine pathway

Copper metabolism

Disorders of fructose metabolism

Disorders of bile acid synthesis and biliary transport

Disorders in ketone body synthesis

Disorders of galactose metabolism

Iron metabolism disorders

Hemesynthesis defects and porphyrias

Glyoxylate metabolism

Ethylmalonic encephalopathy

FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Leucine, isoleucine and valine metabolism

Urea cycle and associated pathways

Urea cycle and related diseases

Hippo-Merlin signaling dysregulation

Inflammatory response pathway

Glycosylation and related congenital defects

Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases

Molybdenum cofactor (Moco) biosynthesis

Methionine metabolism leading to sulfur amino acids and related disorders

MTHFR deficiency

Vitamin B12 disorders

Krebs cycle disorders

Pyrimidine metabolism and related diseases

Purine metabolism and related disorders

GABA metabolism (aka GHB)

Hepatitis C and hepatocellular carcinoma

MECP2 and associated Rett syndrome

Complement activation

Thyroid hormone imbalance leading to neurodevelopmental abnormalities

Cholesterol synthesis disorders

Calcium mediated T-cell apoptosis involved in inclusion body myositis

Mitochondrial fatty acid oxidation disorders

Proline and hydroxyproline pathways

Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Cerebral organic acidurias, including diseases

Tyrosine metabolism and related disorders

Chromosomal and microsatellite instability in colorectal cancer

Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine

Copper homeostasis

Apoptosis

Codeine and morphine metabolism

Phase I biotransformations, non-P450

Phase I biotransformations, non-P450

Phase I biotransformations, non-P450

Phase I biotransformations, non-P450

Cancer immunotherapy by CTLA4 blockade

Angiopoietin-like protein 8 regulatory pathway

BDNF-TrkB signaling

ATM signaling pathway

Amyotrophic lateral sclerosis (ALS)

Cholesterol biosynthesis pathway

Apoptosis modulation and signaling

AMP-activated protein kinase signaling

KCNQ2-related epilepsies

Glycolysis and gluconeogenesis

Acetylcholine synthesis

Activation of NLRP3 inflammasome by SARS-CoV-2

Hippo signaling regulation pathways

Canonical and non-canonical TGF-B signaling

PCSK9-mediated LDL receptor degradation

Synaptic vesicle pathway

Alzheimer's disease and miRNA effects

Th17 cell differentiation pathway

Focal adhesion

Nucleotide GPCRs

Tryptophan metabolism

Toll-like receptor signaling pathway

Insulin signaling

Notch signaling pathway

Monoamine GPCRs

Steroid biosynthesis

Estradiol regulation in porto-sinusoidal vascular disease

Regulation of actin cytoskeleton

Prostaglandin signaling

Hedgehog signaling pathway

G1 to S cell cycle control

GPCRs, class C metabotropic glutamate, pheromone

GPCRs, other

Inflammatory response pathway

G protein signaling pathways

IDO metabolic pathway

Fatty acid omega-oxidation

Translation factors

Notch signaling pathway

Fatty acid beta-oxidation 3

Peptide GPCRs

Statin pathway

T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection

Glycine metabolism, including IMDs

MYD88 distinct input-output pathway

Canonical and non-canonical Notch signaling

SREBF and miR33 in cholesterol and lipid homeostasis

Sterol regulatory element-binding proteins (SREBP) signaling

PGK1, PKM2, KHKC/KHKA acting as protein kinases

EV release from cardiac cells and their functional effects

Androgen receptor network in prostate cancer

Embryonic stem cell pluripotency pathways

High-osmolarity glycerol (HOG) pathway

Renin-angiotensin-aldosterone system (RAAS)

Interleukin-1 (IL-1) structural pathway

ErbB signaling pathway

Methionine de novo and salvage pathway

Non-canonical Wnt pathway

Affected pathways in Duchenne muscular dystrophy

Sphingolipid metabolism in senescence

Hematopoietic stem cell gene regulation by GABP alpha/beta complex

Blood clotting cascade

Cardiac progenitor differentiation

IL-19 signaling pathway

Glycolysis in senescence

Carnosine metabolism of glial cells

Kynurenine pathway and links to cell senescence

Nucleotide excision repair

Base excision repair

Fragile X syndrome

Wnt signaling pathway and pluripotency

Kallmann syndrome

Pentose phosphate pathway in senescent cells

Primary ovarian insufficiency

TCA cycle

Kennedy pathway from sphingolipids

Acute myeloid leukemia

Ras signaling

lncRNA in canonical Wnt signaling and colorectal cancer

Pleural mesothelioma

Wnt signaling

Hedgehog signaling pathway

Fibrin complement receptor 3 signaling pathway

Clear cell renal cell carcinoma pathways

Cell cycle

Osteoblast differentiation and related diseases

Transcriptional activation by NRF2 in response to phytochemicals

EGFR tyrosine kinase inhibitor resistance

Hippo-YAP signaling

Focal adhesion

Complement system

Prader-Willi and Angelman syndrome

Vitamin K metabolism and activation of dependent proteins

TCA cycle (plant)

Warburg effect modulated by deubiquitinating enzymes and their substrates

Network map of SARS-CoV-2 signaling pathway

D-arginine and D-ornithine metabolism

Diet-dependent trimethylamine/trimethylamine N-oxide metabolism

Osteoblast signaling

Pantothenate and coenzyme A biosynthesis

Nuclear receptors meta-pathway

Nicotine effect on chromaffin cells

Osteoclast signaling

CAMKK2 pathway

Pre-implantation embryo

Electron transport chain: OXPHOS system in mitochondria

Glycerophospholipid biosynthetic pathway

TROP2 regulatory signaling

Comprehensive IL-17A signaling

Aryl hydrocarbon receptor pathway

Eicosanoid metabolism via cyclooxygenases (COX)

CCL18 signaling pathway

Integrated cancer pathway

VEGF-receptor signal transduction

Glucocorticoid effect on target gene expression

Cori cycle

Mechanisms associated with pluripotency

TP53 network

Iron homeostasis

Folate-alcohol and cancer pathway hypotheses

Transcription factors regulate miRNAs related to cardiac hypertrophy

Metapathway signal transduction

MicroRNAs in cardiomyocyte hypertrophy

Energy metabolism

Flavonoid biosynthesis

miRNA regulation of DNA damage response

Regulation of cardiac hypertrophy by miR-208

Oxidative damage response

Glycine metabolism

Opioid receptor pathways

Dopaminergic neurogenesis

Brain-derived neurotrophic factor (BDNF) signaling pathway

Oncostatin M signaling pathway

Corticotropin-releasing hormone signaling pathway

Interleukin-11 signaling pathway

AGE/RAGE pathway

Thymic stromal lymphopoietin (TSLP) signaling pathway

Heart development

Nicotine effect on dopaminergic neurons

Fluoropyrimidine activity

Mitochondrial long chain fatty acid beta-oxidation

Parkinson's disease

Alpha 6 beta 4 signaling pathway

IL-7 signaling pathway

Target of rapamycin signaling

Photosynthetic carbon reduction

Serotonin transporter activity

IL-4 signaling pathway

VEGFA-VEGFR2 signaling

Apoptosis modulation by HSP70

MAPK signaling pathway

Triacylglyceride synthesis

Osteoblast signaling

Notch signaling

Small ligand GPCRs

Prolactin signaling pathway

TNF-related weak inducer of apoptosis (TWEAK) signaling pathway

Follicle stimulating hormone (FSH) signaling pathway

Leptin signaling pathway

Thyroid stimulating hormone (TSH) signaling pathway

RANKL/RANK signaling pathway

Response regulator aspartate phosphatase interactions

Netrin-UNC5B signaling pathway

Gastrin signaling pathway

Pyrimidine metabolism

Androgen receptor signaling pathway

IL-2 signaling pathway

EGF/EGFR signaling pathway

mRNA processing

Eukaryotic transcription initiation

p38 MAPK signaling pathway

IL6 signaling pathway

Wnt signaling pathway

Fas ligand pathway and stress induction of heat shock proteins

Kit receptor signaling pathway

Nuclear receptors in lipid metabolism and toxicity

Myometrial relaxation and contraction pathways

IL-3 signaling pathway

S1P receptor signal transduction

Osteopontin signaling

Nucleotide-binding oligomerization domain (NOD) pathway

B cell receptor signaling pathway

IL-9 signaling pathway

IL-1 signaling pathway

Homologous recombination

Integrin-mediated cell adhesion

Bone morphogenic protein signaling and regulation

Pentose phosphate metabolism

IL-5 signaling pathway

Translation factors

TGF-beta receptor signaling

Complement and coagulation cascades

Biogenic amine synthesis

Calcium regulation in cardiac cells

Hypertrophy model

Sulfation biotransformation reaction

T-cell receptor signaling pathway

Arachidonate epoxygenase / epoxide hydrolase

Glucose homeostasis

Abscisic acid biosynthesis

Flower development

ID signaling pathway

Glycogen synthesis and degradation

Prostaglandin synthesis and regulation

Pyrimidine ribonucleotide salvage pathways

DNA damage response (only ATM dependent)

Orexin receptor pathway

Omega-9 fatty acid synthesis

Eicosanoid metabolism via lipoxygenases (LOX)

Fructose metabolism in proximal tubules

Bacterial ceramide synthesis

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF/GATA4 signaling

Serotonin HTR1 group and FOS pathway

Serotonin transporter activity

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF / GATA4 signaling

Serotonin receptor 2 and STAT3 signaling

Serotonin receptor 2 and STAT3 signaling

IL-9 signaling pathway

IL-6 signaling pathway

Metabolic pathways of fibroblasts

Mitochondrial complex I inhibition leading to parkinsonian motor deficits

Cysteine biosynthesis from homoserine

Meiotic recombination genes

Osteoclast signaling

GPCRs, class A rhodopsin-like

Pyruvate dehydrogenase pathway

Sucrose biosynthesis

Colanic acid building blocks biosynthesis

Retinol metabolism

Inclusion body myositis

Type I interferon induction and signaling during SARS-CoV-2 infection

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Glycerophospholipid biosynthetic pathway

TCA cycle

Wnt signaling pathway and pluripotency

ATM signaling pathway

Glycerol teichoic acid biosynthesis

PtdIns(4,5)P2 in cytokinesis pathway

Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution

Leukotriene metabolic pathway

Burn wound healing

SARS-CoV-2 innate immunity evasion and cell-specific immune response

GDNF/RET signaling axis

GDNF/RET signaling axis

Oxidative stress and redox pathway

Metabolism of tetrahydrocannabinol (THC)

Primary focal segmental glomerulosclerosis (FSGS)

Quercetin and Nf-kB / AP-1 induced cell apoptosis

Cardiac progenitor differentiation

Primary carbon metabolism

Pentose phosphate pathway

Primary focal segmental glomerulosclerosis (FSGS)

Seed development

Cardiolipin biosynthesis

Seed development

DNA replication

Oxidation by cytochrome P450

Translation factors

Oxidation by cytochrome P450

Pentose phosphate pathway

Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

Mitochondrial long chain fatty acid beta-oxidation

Phospholipid biosynthesis

Heme biosynthesis

Roles of ceramides in development of insulin resistance

TCA cycle in senescence

Deregulation of renin-angiotensin system by SARS-CoV infection

Sphingolipid metabolism: integrated pathway

Omega-9 fatty acid synthesis

Omega-3 / omega-6 fatty acid synthesis

Glycerolipids and glycerophospholipids

Eicosanoid metabolism via lipooxygenases (LOX)

Eicosanoid metabolism via cytochrome P450 monooxygenases pathway

Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

Sphingolipid metabolism (integrated pathway)

Omega-3 / omega-6 fatty acid synthesis

Eicosanoid metabolism via cytochrome P450 monooxygenases

Eicosanoid metabolism via cyclooxygenases (COX)

Glycerolipids and glycerophospholipids

Sphingolipid metabolism overview

Fatty acid beta-oxidation 1

De novo biosynthesis of pyrimidine deoxyribonucleotides

Nod-like receptor (NLR) signaling pathway

Pregnane X receptor pathway

Triglyceride biosynthesis

Heme biosynthesis

Eicosanoid synthesis

Fatty acid elongation, unsaturated

Selenium micronutrient network

Fatty acid beta-oxidation

Folic acid network

Folic acid network

Fatty acid beta-oxidation

Sulfur amino acid biosynthesis

Triacylglyceride synthesis

Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists

COVID-19 and endothelial cell senescence

Mitochondrial beta-oxidation

Lac-Phe pathway

Clock-controlled autophagy in bone metabolism

Pro-survival signaling of neuroprotectin D1

Arachidonic acid (AA, ARA) oxylipin metabolism

Arachidonate epoxygenase / epoxide hydrolase

Myometrial relaxation and contraction pathways

Myometrial relaxation and contraction pathways

Myometrial relaxation and contraction pathways

Notch signaling pathway

COVID-19, thrombosis and anticoagulation

Vitamin D in inflammatory diseases

Resistin as a regulator of inflammation

TLR4 signaling and tolerance

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Overview of nanoparticle effects

PDGF pathway

Folate metabolism

Non-classical role of vitamin D

Steroid biosynthesis

Retinoblastoma gene in cancer

Glycolysis and gluconeogenesis

Actin cytoskeleton regulation

FAS pathway and stress induction of HSP regulation

Selenium micronutrient network

Blood clotting cascade

Vitamin B12 metabolism

Selenium micronutrient network

Selenium micronutrient network

Folate metabolism

Hair follicle development: cytodifferentiation - part 3 of 3

Tryptophan degradation via kynurenine

Pluripotent stem cell differentiation pathway

Spinal cord injury

Allograft rejection

Cells and molecules involved in local acute inflammatory response

MAPK pathway in congenital thyroid cancer

Microglia pathogen phagocytosis pathway

Regulation of actin cytoskeleton

Biogenic amine synthesis

Quercetin and Nf-kB / AP-1 induced apoptosis

ABA biosynthesis

ID signaling pathway

ID signaling pathway

Leukocyte-intrinsic Hippo pathway functions

DNA IR-damage and cellular response via ATR

ID signaling pathway

TGF-beta signaling pathway

TNF-alpha signaling pathway

ID signaling pathway

Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex

miR-222 in exercise-induced cardiac growth

Melatonin metabolism and effects

Aryl hydrocarbon receptor pathway

GDNF signaling

Ebola virus infection in host

SARS-CoV-2 and ACE2 receptor: molecular mechanisms

Wnt signaling pathway

Wnt signaling pathway

Airway smooth muscle cell contraction

LDLRAD4 and what we know about it

Hijack of ubiquitination by SARS-CoV-2

SARS-CoV-2 and COVID-19 pathway

Wnt signaling pathway

BDNF pathway

Insulin signaling

RAC1/PAK1/p38/MMP2 pathway

COVID-19 adverse outcome pathway

Photodynamic therapy-induced AP-1 survival signaling

MAPK signaling pathway

Cell cycle

Triacylglyceride synthesis

Wnt signaling pathway and pluripotency

Arginine biosynthesis

Neuroinflammation and glutamatergic signaling

Serine metabolism

Joubert syndrome

Long-day flowering time pathway

Cell differentiation - index

Burn wound healing

Spinal cord injury

Statin inhibition of cholesterol production

Linoleic acid oxylipin metabolism

nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell

Interactions of natural killer cells in pancreatic cancer

Beta-oxidation of unsaturated fatty acids

Trehalose degradation, low osmolarity

Cori cycle

Male infertility

Parkin-ubiquitin proteasomal system pathway

Vitamin D receptor pathway

Burn wound healing

Nod-like receptor (NLR) signaling pathway

Nicotine metabolism in liver cells

Prostaglandin and leukotriene metabolism in senescence

Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway

Gut-liver indole metabolism

Role of carnosine in muscle contraction

Hormonal control of pubertal growth spurt

Host-pathogen interaction of human coronaviruses - MAPK signaling

Oxidation by cytochrome P450

Wnt signaling pathway and pluripotency

One-carbon metabolism and related pathways

Primary focal segmental glomerulosclerosis (FSGS)

Arrhythmogenic right ventricular cardiomyopathy

Progeria-associated lipodystrophy

Familial partial lipodystrophy

Congenital generalized lipodystrophy

Ketogenesis and ketolysis

Biotin metabolism, including IMDs

Hypoxia-dependent proliferation of myoblasts

EGF/EGFR signaling pathway

Distal convoluted tubule 1 (DCT1) cell

NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

NAD+ metabolism

Endoplasmic reticulum stress response in coronavirus infection

Beta-oxidation of unsaturated fatty acids

Beta-oxidation meta-pathway

NAD+ biosynthetic pathways

miR-222 in exercise-induced cardiac growth

Ovarian infertility

Fatty acid beta-oxidation meta-pathway

Complement system in neuronal development and plasticity

Soluble ACE2-mediated cell entry of SARS-CoV-2

SARS-CoV-2 altering angiogenesis via NRP1

Flowering time pathway

Valine biosynthesis

Toll-like receptor signaling pathway

Hepatocyte growth factor receptor signaling

Hepatocyte growth factor receptor signaling

FOXP3 in COVID-19

Hepatocyte growth factor receptor signaling

Hepatocyte growth factor receptor signaling

Cytokinin-auxin interactions in plant development

Polar auxin transport

Wnt signaling pathway

Fatty acid beta-oxidation 3

Glucosinolate biosynthesis from branched-chain amino acid

Glucosinolate biosynthesis from methionine

Mitochondrial long chain fatty acid beta-oxidation

Ketone bodies synthesis and degradation

Nodal signaling pathway

UDP-L-arabinose biosynthesis I from UDP-xylose

Triacylglyceride synthesis

Fatty acid beta-oxidation 2

Eukaryotic transcription initiation

Vulval development and SynMuv

Proteasome degradation

Glycogen metabolism

ERK1-ERK2 MAPK cascade

DNA IR-double strand breaks and cellular response via ATM

Leptin-insulin signaling overlap

Caffeine and theobromine metabolism

Pentose phosphate pathway

Role of lipid metabolism

Differentiation of white and brown adipocyte

Mesodermal commitment pathway

Programmed cell death and cell engulfment

Sucrose metabolism

Starch metabolism

ER stress-unfolded protein response (UPRer)

EGF signaling in vulval development

Notch signaling in vulval development

Eukaryotic transcription initiation

Cell division: first embryonic mitosis

Monoamine GPCRs

Fatty acid beta-oxidation 1

Pentose phosphate pathway

Cholesterol biosynthesis

Eukaryotic transcription initiation

Homologous recombination

Programmed cell death

Deregulation of Rab and Rab effector genes in bladder cancer

De novo biosynthesis of purine nucleotides

Eukaryotic transcription initiation

Nitric oxide metabolism in cystic fibrosis

Regulation of Wnt / B-catenin signaling by small molecule compounds

Crystal toxin triggered necrosis pathway

Folate biosynthesis

Programmed cell death and cell engulfment

Ascaroside biosynthesis

Wnt signaling in cell polarity

Alpha 6 beta 4 signaling pathway

Wnt signaling pathway and pluripotency

Pentose phosphate pathway

EGFR1 signaling pathway

FAS pathway and stress induction of HSP regulation

Signal transduction of S1P receptor

Eukaryotic transcription initiation

Calcium regulation in cardiac cells

Exercise-induced circadian regulation

Mapk signaling pathway

Alpha 6 beta 4 integrin signaling pathway

Blood clotting cascade

Inflammatory response pathway

Canonical NF-kB pathway

GPCRs, class B secretin-like

Osteoclast signaling

IL-2 signaling pathway

Matrix metalloproteinases

PDGFR-alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine

TCA cycle

Eicosanoid lipid synthesis map

Kit receptor signaling pathway

Mitochondrial long chain fatty acid beta-oxidation

IL-6 signaling pathway

Robo4 and VEGF signaling pathways crosstalk

Triacylglyceride synthesis

Prostaglandin synthesis and regulation

IL-3 signaling pathway

IL-1 signaling pathway

BMP signaling pathway in eyelid development

Interleukin-1 induced activation of NF-kB

GPCRs, small ligand

GPCRs, class C metabotropic glutamate, pheromone

Aryl hydrocarbon receptor pathway

Eicosanoid synthesis

Interleukin-1 (IL-1) structural pathway

IL-17 signaling pathway

Glycogen metabolism

Translation factors

IL-7 signaling pathway

Electron transport chain

miR302-367 promoting cardiomyocyte proliferation

Wnt signaling - Q neuroblast migration

Delta-Notch signaling pathway

Acetylcholine synthesis

Wnt signaling

GPCRs, peptide

G protein signaling pathways

IL-17 signaling pathway

Neural crest differentiation

Hypertrophy model

Complement activation, classical pathway

GPCRs, class A rhodopsin-like

Apoptosis modulation by HSP70

IL-5 signaling pathway

GPCRs, orphan

GPCRs, odorant

GPCRs, non-odorant

IL-4 signaling pathway

Endochondral ossification

SIDS susceptibility pathways

Mitochondrial gene expression

Arachidonate epoxygenase / epoxide hydrolase

Delta-Notch signaling pathway

Hedgehog signaling pathway

Selenium metabolism / selenoproteins

Methylation pathways

Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)

DNA mismatch repair

GPCRs, class C metabotropic glutamate, pheromone

DNA repair pathways, full network

Direct reversal repair

Mitochondrial complex IV assembly

Mitochondrial complex II assembly

Conversion of angiotensinogen to angiotensin II

Amino acid metabolism pathway excerpt: histidine catabolism extension

Neural crest cell migration in cancer

Neural crest cell migration during development

GPCRs, class A rhodopsin-like

Acrylamide biotransformation and exposure biomarkers

NO/cGMP/PKG mediated neuroprotection

Robo4 and VEGF signaling pathways crosstalk

BMP signaling in eyelid development

Mitochondrial gene expression

TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition

Toll-like receptor signaling related to MyD88

Physico-chemical features and toxicity-associated pathways

Tgif disruption of Shh signaling

lncRNA-mediated mechanisms of therapeutic resistance

Interactions between LOXL4 and oxidative stress pathway

Metabolism of dichloroethylene by CYP450

Biochemical pathways: part I

Lipid particles composition

Circadian rhythm genes

GPCRs, class B secretin-like

Estrogen receptor pathway

Glucocorticoid receptor pathway

Constitutive androstane receptor pathway

Hair follicle development: organogenesis - part 2 of 3

Felbamate metabolism

Cardiac hypertrophic response

Aripiprazole metabolic pathway

Sulindac metabolic pathway

Colchicine metabolic pathway

Diclofenac metabolic pathway

TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)

Gastric cancer network 2

Gastric cancer network 1

Deregulation of Rab and Rab effector genes in bladder cancer

Endothelin pathways

Fatty acid omega-oxidation

Cell differentiation - expanded index

SRF and miRs in smooth muscle differentiation and proliferation

Matrix metalloproteinases

GPCRs, other

Cytokines and inflammatory response

EPO receptor signaling

Prostaglandin synthesis and regulation

Methylation pathways

GPCRs, other

Hypertrophy model

Nuclear receptors in lipid metabolism and toxicity

Complement activation, classical pathway

IL-9 signaling pathway

IL-2 signaling pathway

Eicosanoid synthesis

Small ligand GPCRs

Fatty acid omega-oxidation

Striated muscle contraction

IL-5 signaling pathway

Heme biosynthesis

Translation factors

Osteoblast signaling

Glycogen metabolism

Cholesterol biosynthesis

Nuclear receptors

Eukaryotic transcription initiation

Delta-Notch signaling pathway

G13 signaling pathway

Matrix metalloproteinases

G protein signaling pathways

Calcium regulation in cardiac cells

Statin pathway

ACE inhibitor pathway

Notch signaling pathway

Hedgehog signaling pathway

Wnt signaling pathway

Ketone bodies synthesis and degradation

Blood clotting cascade

Kit receptor signaling pathway

Cytokines and inflammatory response

EPO receptor signaling

EGFR1 signaling pathway

Eicosanoid synthesis

Fatty acid omega-oxidation

Heme biosynthesis

Monoterpene biosynthesis pathway in mint

Central carbon metabolism

T cell receptor and co-stimulatory signaling

Heart development

Globo sphingolipid metabolism

Oncostatin M signaling pathway

Fluoropyrimidine activity

Neural crest differentiation

Codeine and morphine metabolism

Nicotine activity on chromaffin cells

TCA cycle nutrient use and invasiveness of ovarian cancer

Cardiac hypertrophic response

Endothelin pathways

Integrated cancer pathway

Endoderm differentiation

Thyroxine (thyroid hormone) production

TWEAK signaling pathway

Sulfation biotransformation reaction

Sphingolipid metabolism

Exercise-induced circadian regulation

NAD biosynthesis II from tryptophan

Thyroid stimulating hormone (TSH) signaling pathway

Aryl hydrocarbon receptor

Synaptic vesicle pathway

Differentiation pathway

ATM signaling pathway

Ganglio sphingolipid metabolism

Membrane trafficking

Nucleotide metabolism

Ectoderm differentiation

Hydrochloric acid secretion in parietal cells

Cell differentiation - index

PDGF pathway

Parkin-ubiquitin proteasomal system pathway

Focal adhesion

Dopaminergic neurogenesis

Arrhythmogenic right ventricular cardiomyopathy

Neurotransmitter release cycle

TSLP signaling pathway

Felbamate metabolism

Colchicine metabolic pathway

Spinal cord injury

Nicotine metabolism

Mesodermal commitment pathway

Nicotine activity on dopaminergic neurons

Microtubule cytoskeleton regulation

Hematopoietic stem cell differentiation

Biogenic amine synthesis

Gastric cancer network 1

Neurotransmitter clearance in synaptic cleft

Vitamin D metabolism

Interleukin-11 signaling pathway

Osteopontin signaling

AMPK signaling

Diclofenac metabolic pathway

Sulindac metabolic pathway

TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)

Apoptosis modulation and signaling

Glycine metabolism

miRNA biogenesis

Mitochondrial gene expression

Constitutive androstane receptor pathway

Histone modifications

Folate-alcohol and cancer pathway

Monoamine transport

Polar auxin transport

Isoprenoid precursor biosynthesis in Pf apicoplasts

IGF-1 signaling

Growth hormone receptor (GHR) signaling

Growth hormone (GH) signaling

Glyoxylate, anapleurotic and succinyl CoA (GAS) pathway

Transcription initiation by sigma factors

NAD biosynthesis I from aspartate

Escherichia coli K-12 peripherome

Osteoblast signaling

Momilactone biosynthesis

Beta-alanine biosynthesis

Carotenoid biosynthesis

Ganglio sphingolipid metabolism

Glycogen metabolism

Cholesterol biosynthesis

Nuclear receptors

Eukaryotic transcription initiation

G13 signaling pathway

Matrix metalloproteinases

G protein signaling pathways

Calcium regulation in cardiac cells

Statin pathway

ACE inhibitor pathway

Notch signaling pathway

Hedgehog signaling pathway

Ketone bodies synthesis and degradation

Wnt signaling pathway and pluripotency

Blood clotting cascade

Kit receptor signaling pathway

Electron transport chain

Biogenic amine synthesis

Cytokines and inflammatory response

EPO receptor signaling

EGFR1 signaling pathway

IL-2 signaling pathway

Eicosanoid synthesis

Heme biosynthesis

S1P receptor signal transduction

Osteoblast signaling

Glycogen metabolism

GPCRs, class A rhodopsin-like

Integrin-mediated cell adhesion

Nuclear receptors

Endochondral ossification

Notch signaling pathway

G13 signaling pathway

Matrix metalloproteinases

Complement and coagulation cascades

IL-4 signaling pathway

GPCRs, class C metabotropic glutamate, pheromone

G protein signaling pathways

TGF-beta receptor signaling

TGF-beta signaling pathway

Calcium regulation in cardiac cell

Inflammatory response pathway

Acetylcholine synthesis

ACE inhibitor pathway

IL-3 signaling pathway

Notch signaling pathway

Glycolysis and gluconeogenesis

B cell receptor signaling pathway

Hedgehog signaling pathway

Wnt signaling pathway

Ketone bodies synthesis and degradation

IL-7 signaling pathway

TCR signaling pathway

Osteoclast signaling

GPCRs, class B secretin-like

Electron transport chain

De novo biosynthesis of pyrimidine ribonucleotides

NAD biosynthesis

Pentose phosphate pathway 2

Asparagine biosynthesis

Mitochondrial tRNA synthetases

Phenylalanine degradation

De novo NAD biosynthesis

Tyrosine biosynthesis

Glycolysis and gluconeogenesis

MAPK signaling pathway

Glycogen catabolism

Phosphatidic acid and phospholipid biosynthesis

Purine fermentation

Methionine degradation

Serine biosynthesis

Eukaryotic transcription initiation

Threonine and methionine biosynthesis

Histidine, purine, and pyrimidine superpathway

Cell cycle and cell division

Trehalose anabolism

Riboflavin, FMN, and FAD biosynthesis

Fatty acid elongation, saturated

Pentose pathway, non-oxidative branch

Sphingolipid metabolism

Pentose phosphate pathway

Isoleucine and valine biosynthesis

Leucine degradation

Protein modifications

Glycine degradation

Threonine biosynthesis

Allantoin degradation

Nucleotide metabolism

Tryptophan degradation

TCA cycle - detailed

Polyamine biosynthesis

Upiquinone Q prenylation

Phenylalanine, tyrosine, and tryptophan biosynthesis

Starch and cellulose biosynthesis

Aerobic glycerol catabolism

Ribose and deoxyribose phosphate metabolism

Cytoplasmic tRNA synthetases

Serine and glycine biosynthesis

Isoleucine, leucine, and valine biosynthesis

Glutathione biosynthesis

Phenylalanine biosynthesis

Glutamate biosynthesis superpathway

P-cymene degradation

Leucine biosynthesis

Isoleucine degradation

NAD salvage pathway

Tryptophan biosynthesis

UDP-N-acetylgalactosamine biosynthesis

Aspartate biosynthesis

Fatty acid biosynthesis, initial steps

Cholesterol biosynthesis

DNA replication

Homocysteine and cysteine interconversion

Principal pathways of carbon metabolism

UDP-glucose conversion

Nuclear receptors

Regulation of actin cytoskeleton

Matrix metalloproteinases

Inhibitor of DNA binding (ID) signaling pathway

Notch signaling pathway

mRNA processing

Hedgehog signaling pathway

Wnt signaling pathway

Kit receptor signaling pathway

MAPK signaling pathway

Mitochondrial long chain fatty acid beta-oxidation

Triacylglycerol biosynthesis

Biosynthesis of gamma-aminobutyric acid (GABA) by polyamine oxidation

Glucose sensing and signaling

Toll, IMD, JAK/STAT pathways for immune response to pathogens

Genetic interactions between sugar and hormone signaling

TCA cycle (Krebs cycle)

Chlorophyll b degradation

Flower development: initiation

Linoleate biosynthesis

Eukaryotic transcription initiation

TCA cycle

Heme biosynthesis

Glycogen metabolism

Cholesterol biosynthesis

Delta-Notch signaling pathway

G13 signaling pathway

G protein signaling pathways

Calcium regulation in cardiac cells

ACE inhibitor pathway

FAS pathway and stress induction of HSP regulation

Ketone bodies synthesis and degradation

Blood clotting cascade

EPO receptor signaling

EGFR1 signaling pathway

Polyol pathway

GPR40 pathway

Imatinib and chronic myeloid leukemia

T cell receptor and co-stimulatory signaling

NAD biosynthesis II (from tryptophan)

miRNA biogenesis

Neural crest differentiation

Microtubule cytoskeleton regulation

EPO receptor signaling

G13 signaling pathway

Exercise-induced circadian regulation

Wnt signaling pathway

Apoptosis modulation by HSP70

Nod-like receptor (NLR) signaling pathway

FAS pathway and stress induction of HSP regulation

Heme biosynthesis

IL-9 signaling pathway

G protein signaling pathways

Steroid biosynthesis

Cardiovascular signaling

Hedgehog signaling pathway

IL-2 signaling pathway

ACE inhibitor pathway

Complement and coagulation cascades

Cytoplasmic ribosomal proteins

Translation factors

mRNA processing

Mitochondrial unfolded-protein response

G13 signaling pathway

Proteasome degradation

Notch signaling pathway

Biosynthesis of aldosterone and cortisol

Hedgehog signaling pathway

Osteoclast

Apoptosis modulation by HSP70

Cytoplasmic ribosomal proteins

TNF-alpha NF-kB signaling pathway

Hypertrophy model

IL-5 signaling pathway

Oxidative stress response

GPCRs, other

Mitochondrial long chain fatty acid beta-oxidation

Oxidative damage response

Amino acid metabolism

Lipid droplet metabolism

Thick ascending limb transporters

Proximal tubule transporters

Toll, IMD, JAK/STAT pathways for immune response to pathogens

GPCRs, class B secretin-like

Humoral immune response to fungal and bacterial pathogens

Acetylcholine synthesis

IL-1 signaling pathway

Regulation of actin cytoskeleton

Synthesis and degradation of ketone bodies

TCA cycle

Glial cell differentiation

IL-3 signaling pathway

Striated muscle contraction

Glucocorticoid metabolism

Prostaglandin synthesis and regulation

Proteasome degradation

mir219 in oligodendrocyte differentiation and myelination

Proteasome degradation

Matrix metalloproteinases

Heme biosynthesis

Chicken limb development

Sulindac metabolic pathway

Nuclear receptors

Cytoplasmic ribosomal proteins

Notch signaling pathway

Focal adhesion

Proteasome degradation

Oxidative stress response

Cytoplasmic ribosomal proteins

Small ligand GPCRs

Glycogen metabolism

Proteasome degradation

Translation factors

Kit receptor signaling pathway

Nucleotide metabolism

Statin pathway

Fatty acid omega-oxidation

S1P receptor signal transduction

Mitochondrial gene expression

Nod-like receptor (NLR) signaling pathway

EPO receptor signaling

Hypothetical network for drug addiction

Transcriptional activation by Nfe2l2 in response to phytochemicals

Nod-like receptor (NLR) signaling pathway

Cytoplasmic ribosomal proteins

Homologous recombination

FAS pathway and stress induction of HSP regulation

Apoptosis modulation by HSP70

Proteasome degradation

Cytoplasmic ribosomal proteins

Oxidative stress response

Nod-like receptor (NLR) signaling pathway

Synthesis and degradation of ketone bodies

DNA replication

Mitochondrial long chain fatty acid beta-oxidation

PPAR signaling pathway

Glycogen metabolism

Oxidative stress response

Glycolysis and gluconeogenesis

Estrogen signaling

Hypertrophy model

MAPK signaling pathway

Insulin signaling

p38 MAPK signaling pathway

MAPK signaling pathway

p38 MAPK signaling pathway

Monoamine transport

Amino acid metabolism

Leptin-insulin signaling overlap

Exercise-induced circadian regulation

Synthesis and degradation of ketone bodies

Biogenic amine synthesis

Acetylcholine synthesis

ACE inhibitor pathway

DNA replication

Insulin signaling

ACE inhibitor pathway

Microglia pathogen phagocytosis pathway

MAPK signaling pathway

Target of rapamycin (TOR) signaling

Cytoplasmic ribosomal proteins

G13 signaling pathway

p38 Mapk signaling pathway

Common pathways underlying drug addiction

Spinal cord injury

Cytokines and inflammatory response

Acetylcholine synthesis

Glycolysis and gluconeogenesis

MicroRNAs in cardiomyocyte hypertrophy

Biogenic amine synthesis

Cholesterol biosynthesis

Electron transport chain

EPO receptor signaling

Eicosanoid synthesis

Insulin signaling

p38 MAPK signaling pathway

Cholesterol biosynthesis

MAPK signaling pathway

Ectoderm differentiation

Integrin-mediated cell adhesion

MAPK cascade

Novel Jun-Dmp1 pathway

p38 Mapk signaling pathway

ESC pluripotency pathways

Mapk cascade

EPO receptor signaling

Transcriptional activation by Nfe2l2 in response to phytochemicals

FOXA2 pathway

Mitochondrial complex III assembly

Biotic stress response gene network

TYROBP causal network in microglia

Renin-angiotensin system

Wnt/beta-catenin signaling pathway in leukemia