Cardiomyocyte signaling converging on titin (WP5344)

Homo sapiens

Involvement of titin in cardiomyocyte signaling pathways and its effect on protein quality control pathways as well as hypertrophic signaling within a cardiomyocyte.

Authors

Beppie , Isa Leenders , Sena , Javier Millán Acosta , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway Ras superfamily mediated signaling pathway

Cell Type Ontology

cardiac muscle cell

Participants

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
GTP(4 - ) Metabolite chebi:37565
NO Metabolite chebi:16480
3',5'-cyclic GMP Metabolite chebi:16356
3',5'-cyclic AMP Metabolite chebi:17489
ATP Metabolite chebi:30616
TTN GeneProduct ensembl:ENSG00000155657
TTN GeneProduct ensembl:ENSG00000155657
TTN GeneProduct ensembl:ENSG00000155657
TTN GeneProduct ensembl:ENSG00000155657
TTN GeneProduct ensembl:ENSG00000155657
TTN GeneProduct ensembl:ENSG00000155657
TTN GeneProduct ensembl:ENSG00000155657
TTN GeneProduct ensembl:ENSG00000155657
NPR1 GeneProduct uniprot:P16066
PRKAR1A GeneProduct ensembl:ENSG00000108946
ANKRD23 GeneProduct ensembl:ENSG00000163126
GUCD1 GeneProduct ensembl:ENSG00000138867
FHL1 GeneProduct uniprot:Q13642
SRF GeneProduct uniprot:P11831
ANKRD1 GeneProduct ensembl:ENSG00000148677
GUCY1B1 GeneProduct ensembl:ENSG00000061918
TCAP GeneProduct ensembl:ENSG00000173991
PRKACB GeneProduct ensembl:ENSG00000142875
MAPK1 GeneProduct ensembl:ENSG00000100030
PRKACA GeneProduct uniprot:P17612
MYPN GeneProduct ensembl:ENSG00000138347
PRKCA GeneProduct ensembl:ENSG00000154229
RAS GeneProduct uniprot:P01114
CSRP3 GeneProduct ensembl:ENSG00000129170
CAMK2A GeneProduct ensembl:ENSG00000070808
PRKACG GeneProduct ensembl:ENSG00000165059
ANKRD2 GeneProduct ensembl:ENSG00000165887
PRKG2 GeneProduct uniprot:Q13237
TRIM55 GeneProduct uniprot:Q9BYV6
NBR1 GeneProduct uniprot:Q14596
Capn1 GeneProduct uniprot:Q3TB79
CRYAB GeneProduct uniprot:P02511
NUP62 GeneProduct uniprot:P37198
TRIM63 GeneProduct uniprot:Q969Q1
FHL2 GeneProduct uniprot:Q14192
MDM2 GeneProduct uniprot:Q00987
FHL2 GeneProduct uniprot:Q14192
MAP2K1 GeneProduct uniprot:Q02750
MAP2K2 GeneProduct uniprot:P36507
RAF1 GeneProduct uniprot:P04049
GPCR GeneProduct uniprot:Q8TDU1
PLCZ1 GeneProduct ensembl:ENSG00000139151
ADRB2 GeneProduct uniprot:P07550
ADRB1 GeneProduct uniprot:P08588
Adenylyl cyclase GeneProduct uniprot:Q59FG4

References

  1. The giant protein titin: a regulatory node that integrates myocyte signaling pathways. Krüger M, Linke WA. J Biol Chem. 2011 Mar 25;286(12):9905–12. PubMed Europe PMC Scholia
  2. Gigantic business: titin properties and function through thick and thin. Linke WA, Hamdani N. Circ Res. 2014 Mar 14;114(6):1052–68. PubMed Europe PMC Scholia