Cardiomyocyte signaling converging on titin (WP5344)

Homo sapiens

Involvement of titin in cardiomyocyte signaling pathways and its effect on protein quality control pathways as well as hypertrophic signaling within a cardiomyocyte.

Authors

Beppie , Isa Leenders , Sena , Javier Millán Acosta , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway Ras superfamily mediated signaling pathway

Cell Type Ontology

cardiac muscle cell

Participants

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
GTP(4 - ) Metabolite chebi:37565
NO Metabolite chebi:16480
3',5'-cyclic GMP Metabolite chebi:16356
3',5'-cyclic AMP Metabolite chebi:17489
ATP Metabolite chebi:30616
TTN GeneProduct ensembl:ENSG00000155657
NPR1 GeneProduct uniprot:P16066
PRKAR1A GeneProduct ensembl:ENSG00000108946
ANKRD23 GeneProduct ensembl:ENSG00000163126
GUCD1 GeneProduct ensembl:ENSG00000138867
FHL1 GeneProduct uniprot:Q13642
SRF GeneProduct uniprot:P11831
ANKRD1 GeneProduct ensembl:ENSG00000148677
GUCY1B1 GeneProduct ensembl:ENSG00000061918
TCAP GeneProduct ensembl:ENSG00000173991
PRKACB GeneProduct ensembl:ENSG00000142875
MAPK1 GeneProduct ensembl:ENSG00000100030
PRKACA GeneProduct uniprot:P17612
MYPN GeneProduct ensembl:ENSG00000138347
PRKCA GeneProduct ensembl:ENSG00000154229
RAS GeneProduct uniprot:P01114
CSRP3 GeneProduct ensembl:ENSG00000129170
CAMK2A GeneProduct ensembl:ENSG00000070808
PRKACG GeneProduct ensembl:ENSG00000165059
ANKRD2 GeneProduct ensembl:ENSG00000165887
PRKG2 GeneProduct uniprot:Q13237
TRIM55 GeneProduct uniprot:Q9BYV6
NBR1 GeneProduct uniprot:Q14596
Capn1 GeneProduct uniprot:Q3TB79
CRYAB GeneProduct uniprot:P02511
NUP62 GeneProduct uniprot:P37198
TRIM63 GeneProduct uniprot:Q969Q1
FHL2 GeneProduct uniprot:Q14192
MDM2 GeneProduct uniprot:Q00987
MAP2K1 GeneProduct uniprot:Q02750
MAP2K2 GeneProduct uniprot:P36507
RAF1 GeneProduct uniprot:P04049
GPCR GeneProduct uniprot:Q8TDU1
PLCZ1 GeneProduct ensembl:ENSG00000139151
ADRB2 GeneProduct uniprot:P07550
ADRB1 GeneProduct uniprot:P08588
Adenylyl cyclase GeneProduct uniprot:Q59FG4

References

  1. The giant protein titin: a regulatory node that integrates myocyte signaling pathways. Krüger M, Linke WA. J Biol Chem. 2011 Mar 25;286(12):9905–12. PubMed Europe PMC Scholia
  2. Gigantic business: titin properties and function through thick and thin. Linke WA, Hamdani N. Circ Res. 2014 Mar 14;114(6):1052–68. PubMed Europe PMC Scholia