Resistin as a regulator of inflammation (WP4481)

Homo sapiens

Resistin induced intracellular signaling pathways. No receptor for resistin has yet been identified. Resistin induces NF-kB activity. Resistin increases the cytosolic Ca concentration via both PLC activation, leading to the release of Ca from intracellular pools, such as the endoplasmic reticulum, and Ca influx from the extracellular environment. Activation of the abovementioned signaling pathways via resistin suggests that it has proinflammatory potential.


Laurent Winckers , Andra Waagmeester , Kristina Hanspers , and Eric Weitz


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Homo sapiens



Pathway Ontology

altered regulatory pathway

Disease Ontology

disease by infectious agent


Label Type Compact URI Comment
ERK1 GeneProduct ncbigene:5595
ERK2 GeneProduct ncbigene:5594
PI3KA GeneProduct ncbigene:5290
PI3KB GeneProduct ncbigene:5291
PI3KD GeneProduct ncbigene:5293
PI3KG GeneProduct ncbigene:5294
AKT1 GeneProduct ncbigene:207
AKT2 GeneProduct ncbigene:208
AKT3 GeneProduct ncbigene:10000
NFKB1 GeneProduct ncbigene:4790
IkBA GeneProduct ncbigene:4792
PLCB1 GeneProduct ncbigene:23236
PLCB2 GeneProduct ncbigene:5330
PLCB3 GeneProduct ncbigene:5331
PLCB4 GeneProduct ncbigene:5332
PLCG1 GeneProduct ncbigene:5335
PLCG2 GeneProduct ncbigene:5336
PLCD1 GeneProduct ncbigene:5333
PLCD4 GeneProduct ncbigene:84812
PLCD3 GeneProduct ncbigene:113026
PLCE1 GeneProduct ncbigene:51196
IL6 GeneProduct ncbigene:3569
IL8 GeneProduct ncbigene:3576
TNF GeneProduct ncbigene:7124
IL12B GeneProduct ncbigene:3593
IL12A GeneProduct ncbigene:3592
IkKA GeneProduct ncbigene:1147
IkKB GeneProduct ncbigene:3551
IkKG GeneProduct ncbigene:8517
RELA GeneProduct ncbigene:5970
ITP3R GeneProduct ncbigene:3708
p38 GeneProduct ncbigene:1432
RETN GeneProduct ncbigene:56729
NFKB1 GeneProduct ncbigene:4790
IkBA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970


  1. Introduction to NF-kappaB: players, pathways, perspectives. Gilmore TD. Oncogene. 2006 Oct 30;25(51):6680–4. PubMed Europe PMC Scholia
  2. The role of resistin as a regulator of inflammation: Implications for various human pathologies. Filková M, Haluzík M, Gay S, Senolt L. Clin Immunol. 2009 Nov;133(2):157–70. PubMed Europe PMC Scholia