Oxidation by cytochrome P450 (WP43)

Homo sapiens

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP43 CPTAC Assay Portal]


Arik , Martijn Van Iersel , Thomas Kelder , Chris Evelo , Susan Coort , Mohhafez , Christine Chichester , Egon Willighagen , Kristina Hanspers , Zahra Roudbari , Martina Summer-Kutmon , Zhangx888 , Eric Weitz , and Finterly Hu


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited By

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

phase I biotransformation pathway via cytochrome P450 xenobiotics biodegradation pathway

Cell Type Ontology



Label Type Compact Identifier Comment
NADPH Metabolite chebi:16474
O2 Metabolite hmdb:HMDB0001377
O2 Metabolite hmdb:HMDB0001377
Fe3+ Metabolite chebi:29034
H2O Metabolite hmdb:HMDB0002111
activated O2 Metabolite hmdb:HMDB0001377
Substrate Metabolite wikidata:Q12119506
Substrate-OH Metabolite wikidata:Q542929
NADP+ Metabolite chebi:18009
Fe3+ Metabolite chebi:29034
Fe3+ Metabolite chebi:29034
Fe2+ Metabolite chebi:29033
Fe2+ Metabolite chebi:29033
Substrate Metabolite wikidata:Q12119506
Substrate Metabolite wikidata:Q12119506
Fe2+ Metabolite chebi:29033
Substrate Metabolite wikidata:Q12119506
Fe3+ Metabolite chebi:29034
Substrate Metabolite wikidata:Q12119506
Fe2+ Metabolite chebi:29033
NADH Metabolite chebi:16908
NAD+ Metabolite chebi:15846
CYP26A1 GeneProduct ensembl:ENSG00000095596
CYP4F11 GeneProduct ensembl:ENSG00000171903
CYB5B GeneProduct ensembl:ENSG00000103018
CYP GeneProduct ncbigene:1559
CYP2C8 GeneProduct ensembl:ENSG00000138115
CYP2B6 GeneProduct ensembl:ENSG00000197408
CYB5R1 GeneProduct ensembl:ENSG00000159348
CYP4F22 GeneProduct ensembl:ENSG00000171954
CYB5A GeneProduct ensembl:ENSG00000166347
CYP GeneProduct ncbigene:1559
CYP4Z1 GeneProduct ensembl:ENSG00000186160
CYP GeneProduct ncbigene:1559
CYP4F8 GeneProduct ensembl:ENSG00000186526
CYP1B1 GeneProduct ensembl:ENSG00000138061
CYP2C18 GeneProduct ensembl:ENSG00000108242
CYB5R4 GeneProduct ensembl:ENSG00000065615
CYP4A22 GeneProduct ensembl:ENSG00000162365
CYB5B GeneProduct ensembl:ENSG00000103018
CYB5R2 GeneProduct ensembl:ENSG00000166394
CYP11B1 GeneProduct ensembl:ENSG00000160882
CYP27B1 GeneProduct ensembl:ENSG00000111012
CYP2A6 GeneProduct ensembl:ENSG00000255974
CYP4F3 GeneProduct ensembl:ENSG00000186529
CYP26C1 GeneProduct ensembl:ENSG00000187553
CYP GeneProduct ncbigene:1559
CYP51A1 GeneProduct ensembl:ENSG00000001630
CYP4A11 GeneProduct ensembl:ENSG00000187048
CYP2A7 GeneProduct ensembl:ENSG00000198077
CYB5B GeneProduct ensembl:ENSG00000103018
CYP7B1 GeneProduct ensembl:ENSG00000172817
CYP GeneProduct ncbigene:1559
CYP19A1 GeneProduct ensembl:ENSG00000137869
CYP21A2 GeneProduct ensembl:ENSG00000198457
CYP3A43 GeneProduct ensembl:ENSG00000021461
CYP26B1 GeneProduct ensembl:ENSG00000003137
CYP7A1 GeneProduct ensembl:ENSG00000167910
CYP3A4 GeneProduct ensembl:ENSG00000160868
CYP2W1 GeneProduct ensembl:ENSG00000073067
CYP8B1 GeneProduct ensembl:ENSG00000180432
CYP2S1 GeneProduct ensembl:ENSG00000167600
CYP39A1 GeneProduct ensembl:ENSG00000146233
CYP2R1 GeneProduct ensembl:ENSG00000186104
CYP46A1 GeneProduct ensembl:ENSG00000036530
CYP4B1 GeneProduct ensembl:ENSG00000142973
CYP1A2 GeneProduct ensembl:ENSG00000140505
CYP4V2 GeneProduct ensembl:ENSG00000145476
CYP2U1 GeneProduct ensembl:ENSG00000155016
CYP2J2 GeneProduct ensembl:ENSG00000134716
CYP2G1P GeneProduct ensembl:ENSG00000130612
CYP4X1 GeneProduct ensembl:ENSG00000186377
CYP51A1 GeneProduct ensembl:ENSG00000001630
CYP2E1 GeneProduct ensembl:ENSG00000130649
CYP11A1 GeneProduct ensembl:ENSG00000140459
CYP20A1 GeneProduct ensembl:ENSG00000119004
POR GeneProduct ensembl:ENSG00000127948
CYP17A1 GeneProduct ensembl:ENSG00000148795
CYP4F2 GeneProduct ensembl:ENSG00000186115
CYP3A5 GeneProduct ensembl:ENSG00000106258
CYP27A1 GeneProduct ensembl:ENSG00000135929
CYP2A13 GeneProduct ensembl:ENSG00000197838
CYP2F1 GeneProduct ensembl:ENSG00000197446
CYP2C19 GeneProduct ensembl:ENSG00000165841
CYP27C1 GeneProduct ensembl:ENSG00000186684
CYB5R3 GeneProduct ensembl:ENSG00000100243
CYP11B2 GeneProduct ensembl:ENSG00000179142
CYP24A1 GeneProduct ensembl:ENSG00000019186
CYP2C9 GeneProduct ensembl:ENSG00000138109
CYP4F12 GeneProduct ensembl:ENSG00000186204
CYP1A1 GeneProduct ensembl:ENSG00000140465
CYB5A GeneProduct ensembl:ENSG00000166347
CYB5A GeneProduct ensembl:ENSG00000166347
CYP2D6 GeneProduct ensembl:ENSG00000100197
CYP3A7 GeneProduct ensembl:ENSG00000160870


  1. Hollinger MA, Niesink R, De Vries J. Toxicology [Internet]. Boca Raton, FL: CRC Press; 1996. 1284 p. Available from: https://openlibrary.org/books/OL791209M/Toxicology OpenLibrary Worldcat