Fluoroacetic acid toxicity (WP4966)

Homo sapiens

Pathway on fluoroacetic acid toxicity describing how it ultimately leads to disturbance of the Krebs cycle.


Marvin Martens , Egon Willighagen , and Denise Slenter


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Homo sapiens



Pathway Ontology

disease pathway altered citric acid cycle pathway altered metabolic pathway


Label Type Compact URI Comment
Isocitric acid Metabolite chebi:30887
4-Hydroxy-trans-aconitate Metabolite wikidata:Q76106265
Fluoroacetic acid Metabolite chebi:30775
Fluoroacetyl-CoA Metabolite pubchem.compound:49859653
Citric acid Metabolite chebi:30769
Acetate Metabolite cas:71-50-1
Fluoroacetaldehyde Metabolite chebi:14272
Fluorocitric acid Metabolite cas:357-89-1
Aconitase GeneProduct ensembl:ENSG00000100412
ALDH3A2 GeneProduct ensembl:ENSG00000072210
ALDH9A1 GeneProduct ensembl:ENSG00000143149
Acetyl-CoA synthetase GeneProduct ensembl:ENSG00000131069
ALDH2 GeneProduct ensembl:ENSG00000111275
Citrate synthase GeneProduct ncbigene:1431


  1. Metabolic and Pharmaceutical Aspects of Fluorinated Compounds. Johnson BM, Shu YZ, Zhuo X, Meanwell NA. J Med Chem. 2020 Jun 25;63(12):6315–86. PubMed Europe PMC Scholia