Thyroid stimulating hormone (TSH) signaling pathway (WP3227)

Bos taurus

Human thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-thyroid by stimulating production and secretion of the thyroid hormone from the thyroid gland. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published.

Authors

Martina Summer-Kutmon , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

thyroid-stimulating hormone signaling pathway

Participants

Label Type Compact URI Comment
CCND3 GeneProduct ensembl:ENSBTAG00000010106 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
BRAF GeneProduct ensembl:ENSBTAG00000021761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
CGA GeneProduct ensembl:ENSBTAG00000016138 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1081
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
SCRIB GeneProduct ensembl:ENSBTAG00000008421 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23513
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
GNB1 GeneProduct ensembl:ENSBTAG00000000215 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
GNG2 GeneProduct ensembl:ENSBTAG00000003043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54331
TSHB GeneProduct ensembl:ENSBTAG00000006295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7252
TSHR GeneProduct ensembl:ENSBTAG00000017489 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7253
STAT3 GeneProduct ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
PDPK1 GeneProduct ensembl:ENSBTAG00000034436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PIK3R1 GeneProduct ensembl:ENSBTAG00000010989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
CDK2 GeneProduct ensembl:ENSBTAG00000004021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
SRC GeneProduct ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K6 GeneProduct ensembl:ENSBTAG00000001609 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
AKT1 GeneProduct ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
RBL2 GeneProduct ensembl:ENSBTAG00000016243 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
RPS6KB1 GeneProduct ensembl:ENSBTAG00000016851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
RB1 GeneProduct ensembl:ENSBTAG00000006640 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
CREB1 GeneProduct ensembl:ENSBTAG00000005474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
PDE4D GeneProduct ensembl:ENSBTAG00000000494 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144
GNAI1 GeneProduct ensembl:ENSBTAG00000002714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770
GNA13 GeneProduct ensembl:ENSBTAG00000046174 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10672
GNAI2 GeneProduct ensembl:ENSBTAG00000020645 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771
GNA12 GeneProduct ensembl:ENSBTAG00000017871 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2768
GNAO1 GeneProduct ensembl:ENSBTAG00000003794 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775
GNAQ GeneProduct ensembl:ENSBTAG00000009789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
GNAI3 GeneProduct ensembl:ENSBTAG00000013016 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773
MYL12B GeneProduct ensembl:ENSBTAG00000026266 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:103910
RALGDS GeneProduct ensembl:ENSBTAG00000004194 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5900
GNAS GeneProduct ensembl:ENSBTAG00000017475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
JAK2 GeneProduct ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JAK1 GeneProduct ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
RPS6 GeneProduct ensembl:ENSBTAG00000014449 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
MTOR GeneProduct ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
ADCY2 GeneProduct ensembl:ENSBTAG00000019210 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108
ADCY3 GeneProduct ensembl:ENSBTAG00000018705 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109
CDK4 GeneProduct ensembl:ENSBTAG00000046091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
RPS6KA1 GeneProduct ensembl:ENSBTAG00000014447 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6195
PRKCSH GeneProduct ensembl:ENSBTAG00000017490 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5337
PLCB1 GeneProduct ensembl:ENSBTAG00000008338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23236
RAP1B GeneProduct ensembl:ENSBTAG00000008967 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
RAP1A GeneProduct ensembl:ENSBTAG00000014710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
IGF1R GeneProduct ensembl:ENSBTAG00000021527 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480
CCNE1 GeneProduct ensembl:ENSBTAG00000004735 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
MAPK14 GeneProduct ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
CDKN1B GeneProduct ensembl:ENSBTAG00000018254 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
RAP1GAP GeneProduct ensembl:ENSBTAG00000008952 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5909
APEX1 GeneProduct ensembl:ENSBTAG00000002745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:328

References

  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia