Oligodendrocyte specification and differentiation, leading to myelin components for CNS (WP4304)
Homo sapiens
Oligodendrocyte differentiation and specification. Also the composition of the myelin sheaths.
Authors
Jesse Vercoulen , Egon Willighagen , Denise Slenter , Kristina Hanspers , Eric Weitz , Finterly Hu , and Martina Summer-KutmonActivity
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Cell Type Ontology
myelin accumulating cell glial cell oligodendrocyte myelin accumulating cell glial cell oligodendrocyte precursor cellPathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| phosphatidylethanolamines | Metabolite | chebi:16038 | |
| Cholesterol 27% | Metabolite | chebi:16113 | |
| Phosphatidylserine 4,8% | Metabolite | chebi:18303 | |
| Cerebrosides 22,7% | Metabolite | chebi:23079 | Even though there are no absolute myelin-specific lipids, cerebroside, also known as galactosylceramide, is the most typical of myelin. The concentration of cerebroside in brain is directly proportional to the amount of myelin present. Cerebroside is not required for myelin formation but plays an important role in its insulating capacity and stability. |
| Sulfatide 3,8% | Metabolite | chebi:18318 | |
| Lecithins 11,2% | Metabolite | chebi:61995 | |
| Sphingomyelin 7,9% | Metabolite | chebi:17636 | |
| phosphatidylinositol | Metabolite | chebi:18179 | |
| Phosphatidylcholine | Metabolite | chebi:16110 | |
| phosphatidic acid | Metabolite | chebi:16337 | |
| T3 | Metabolite | chebi:18258 | |
| CXCL2 | GeneProduct | uniprot:P19875 | |
| FGF | Protein | uniprot:A0A087WUF6 | |
| IGF-1 | Protein | uniprot:P05019 | |
| MOG | Protein | uniprot:Q16653 | MOG: myelin oligodendrocyte glycoprotein |
| Olig2 | Protein | uniprot:Q13516 | |
| PDGF | Protein | uniprot:P01127 | |
| Olig1 | Protein | uniprot:Q8TAK6 | |
| SOX-5 | Protein | uniprot:P35711 | |
| MBP | Protein | uniprot:A8MZH3 | The classic group of MBP isoforms are the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. MBP: myelin basic protein. |
| IL1b | Protein | uniprot:P01584 | |
| OMG | Protein | uniprot:P23515 | OMgp: oligodendrocyte-meylin glycoprotein |
| MAG | Protein | uniprot:P20916 | Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. MAG: myelin associated glycoprotein. |
| PLP1 | Protein | uniprot:P60201 | This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. |
| CNPase | Protein | uniprot:P09543 | May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. CNPase: 2',3'-cyclic nucleotide 3'phosphodiesterase. |
| SHH | Protein | uniprot:Q15465 | Sonic Hedgehog |
| CNTF | Protein | uniprot:P26441 | |
| Nkx-2.2 | Protein | uniprot:O95096 | |
| Mash1 | Protein | uniprot:P50553 | |
| MyT1 | Protein | uniprot:Q01538 | |
| Nkx-2.6 | Protein | uniprot:A6NCS4 | |
| Gli2 | Protein | uniprot:P10070 | |
| SOX-8 | Protein | uniprot:P57073 | |
| SOX-9 | Protein | uniprot:P48436 | |
| SOX-10 | Protein | uniprot:P56693 | |
| SOX-6 | Protein | uniprot:P35712 | |
| BMP4 | Protein | uniprot:P12644 | bone morphogenic proteins |
| bFGF | Protein | uniprot:P09038 | |
| CXCL1 | Protein | uniprot:P09341 | |
| TNFa | Protein | uniprot:P01375 | |
| LIF | Protein | uniprot:P15018 | |
| BMP2 | Protein | uniprot:P12643 | bone morphogenic proteins |
References
- Basic Neurochemistry [Internet]. Siegel GJ, Agranoff BW. Lippincott Raven; 1999. 1216 p. Available from: https://books.google.com/books/about/Basic_Neurochemistry.html?hl=&id=XuFqAAAAMAAJ OpenLibrary Worldcat
- Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Cheng X, Wang Y, He Q, Qiu M, Whittemore SR, Cao Q. Stem Cells. 2007 Dec;25(12):3204–14. PubMed Europe PMC Scholia
- Cells of the oligodendroglial lineage, myelination, and remyelination. Miron VE, Kuhlmann T, Antel JP. Biochim Biophys Acta. 2011 Feb;1812(2):184–93. PubMed Europe PMC Scholia