MAPK pathway in congenital thyroid cancer (WP4928)

Homo sapiens

The MAPK pathway involved in the progression of different diseases such as diabetes, developmental abnormalities and cancer since it has a essential role in the regulation a wide variety of cellular processes such as proliferation, differentiation and apoptosis. consequently, dysregulation of MAPK pathway leads to the occurrence of the related disease


Omran Hasan , Egon Willighagen , Friederike Ehrhart , Eric Weitz , and Alex Pico


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Homo sapiens



Pathway Ontology

altered Erk5 MAPK signaling pathway thyroid cancer pathway

Disease Ontology

thyroid gland cancer


Label Type Compact Identifier Comment
GTP Metabolite chebi:15996
GDP Metabolite chebi:17552
KSR1 GeneProduct ensembl:ENSG00000141068
MAP2K2 GeneProduct ensembl:ENSG00000126934
ELK1 GeneProduct ensembl:ENSG00000126767
c-FOS GeneProduct ensembl:ENSG00000170345
c-MYC GeneProduct ensembl:ENSG00000136997
c-JUN GeneProduct ensembl:ENSG00000177606
CRAF GeneProduct ensembl:ENSG00000132155
MAP2K1 GeneProduct ensembl:ENSG00000169032
SOS2 GeneProduct ensembl:ENSG00000100485
MAPK3 GeneProduct ensembl:ENSG00000102882 Also known as ERK
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MAPK3 GeneProduct ensembl:ENSG00000102882 Also known as ERK
SHC1 GeneProduct ensembl:ENSG00000160691
BRAF GeneProduct ensembl:ENSG00000157764
SOS1 GeneProduct ensembl:ENSG00000115904
RAS Protein ensembl:ENSG00000133703 RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
ALK tyrosine kinase receptor Protein uniprot:Q9UM73
GRB2 Protein uniprot:Q75VX8


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