Cardiac hypertrophic response (WP3250)

Bos taurus

Integrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

hypertrophic cardiomyopathy pathway

Participants

Label Type Compact URI Comment
Ca2+ Metabolite hmdb:HMDB0000464
Ins(1,4,5)P3 Metabolite hmdb:HMDB0001498
DAG Metabolite hmdb:HMDB0007009
Ang-II Metabolite hmdb:HMDB0001035
cGMP Metabolite hmdb:HMDB0001314
MAP3K1 GeneProduct ensembl:ENSBTAG00000013790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
GUCA1A GeneProduct ensembl:ENSBTAG00000012823 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2978
MAP3K7 GeneProduct ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
PLA2G2A GeneProduct ensembl:ENSBTAG00000005759 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5320
PPP3CA GeneProduct ensembl:ENSBTAG00000016005 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5530
CAMK2D GeneProduct ensembl:ENSBTAG00000014463 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:817
MEF2A GeneProduct ensembl:ENSBTAG00000010649 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4205
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKD1 GeneProduct ensembl:ENSBTAG00000012789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
PRKG1 GeneProduct ensembl:ENSBTAG00000018404 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5592
NFATC2 GeneProduct ensembl:ENSBTAG00000018270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4773
MAP4K1 GeneProduct ensembl:ENSBTAG00000021145 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
RAC1 GeneProduct ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAP2K4 GeneProduct ensembl:ENSBTAG00000012103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
MAP2K7 GeneProduct ensembl:ENSBTAG00000010639 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5609
MAPK7 GeneProduct ensembl:ENSBTAG00000001014 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
MAP2K5 GeneProduct ensembl:ENSBTAG00000000218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
MAP2K6 GeneProduct ensembl:ENSBTAG00000001609 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAPK14 GeneProduct ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
IKBKB GeneProduct ensembl:ENSBTAG00000007599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
IKBKE GeneProduct ensembl:ENSBTAG00000010408 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9641
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
CDK7 GeneProduct ensembl:ENSBTAG00000011046 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1022
CDK9 GeneProduct ensembl:ENSBTAG00000004695 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1025
PDPK1 GeneProduct ensembl:ENSBTAG00000034436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
AKT1 GeneProduct ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
AKT2 GeneProduct ensembl:ENSBTAG00000001400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208
GSK3B GeneProduct ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
MTOR GeneProduct ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
HDAC4 GeneProduct ensembl:ENSBTAG00000017764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9759
HDAC7 GeneProduct ensembl:ENSBTAG00000026819 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51564
HDAC5 GeneProduct ensembl:ENSBTAG00000016254 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10014
HDAC9 GeneProduct ensembl:ENSBTAG00000003808 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9734
CHUK GeneProduct ensembl:ENSBTAG00000007591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
IKBKG GeneProduct ensembl:ENSBTAG00000006268 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
FGFR2 Protein ensembl:ENSBTAG00000014064 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2263
TGFBR1 Protein ensembl:ENSBTAG00000018035 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
TNFRSF1A Protein ensembl:ENSBTAG00000004211 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7132
NPPA Protein ensembl:ENSBTAG00000006709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4878
TNF Protein ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
TGFB1 Protein ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
GGFBPP5 Protein ensembl:ENSBTAG00000004150 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3084
IGF-I Protein ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3479
FGF2 Protein ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2247

References

  1. Regulation of cardiac hypertrophy by intracellular signalling pathways. Heineke J, Molkentin JD. Nat Rev Mol Cell Biol. 2006 Aug;7(8):589–600. PubMed Europe PMC Scholia