Glioblastoma signaling pathways (WP2261)
The most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core pathways by TCGA, The Cancer Genome Atlas (see Bibliography). Assembled from literature and public pathway database resources, this representation can easily be kept up to date at WikiPathways.org. Sources: [http://cbio.mskcc.org/cancergenomics/gbm/pathways/GBM_pathway_20080708.pdf cBio Cancer Genomics Portal] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2261 CPTAC Assay Portal]
AuthorsAlex Pico , Daniela Digles , Martina Summer-Kutmon , Kristina Hanspers , Egon Willighagen , Elisson nl , Friederike Ehrhart , and Eric Weitz
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- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
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Pathway Ontologyglioma pathway epidermal growth factor/neuregulin signaling pathway phosphatidylinositol 3-kinase class II signaling pathway Arf family mediated signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway phosphatidylinositol 3-kinase class I signaling pathway fibroblast growth factor signaling pathway protein kinase C (PKC) signaling pathway p53 signaling pathway
Cell Type Ontologyglioblast
Disease Ontologybrain cancer glioblastoma cancer
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Cancer Genome Atlas Research Network. Nature. 2008 Oct 23;455(7216):1061–8. PubMed Europe PMC Scholia
- Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, et al. J Biol Chem. 2009 Jul 3;284(27):18515–24. PubMed Europe PMC Scholia
- Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P, et al. Lab Invest. 2010 Feb;90(2):144–55. PubMed Europe PMC Scholia
- MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, et al. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098–103. PubMed Europe PMC Scholia
- Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. Kwak HJ, Kim YJ, Chun KR, Woo YM, Park SJ, Jeong JA, et al. Oncogene. 2011 May 26;30(21):2433–42. PubMed Europe PMC Scholia
- MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4. Liu X, Zhang Z, Sun L, Chai N, Tang S, Jin J, et al. Carcinogenesis. 2011 Dec;32(12):1798–805. PubMed Europe PMC Scholia