Welcome to the ExRNA Pathway Portal
The Common Fund strategic planning process has developed a program on Extracellular RNA Communication. This program aims to discover fundamental biological principles about the mechanisms of exRNA generation, secretion, and transport; to identify and develop a catalog of exRNA found in normal human body fluids; and to investigate the potential for using exRNAs in the clinic as therapeutic molecules or biomarkers of disease. To find out more about the program, visit exrna.org.
Contact
David Chen and Varduhi Petrosyan .
Community Pathways
Table FiltersThis community helps to curate 66 pathways:
- Alzheimer's disease and miRNA effects - WP2059 (Homo sapiens)
- ApoE and miR-146 in inflammation and atherosclerosis - WP3926 (Homo sapiens)
- Apoptosis-related network due to altered Notch3 in ovarian cancer - WP2864 (Homo sapiens)
- Cell differentiation - index - WP2029 (Homo sapiens)
- Circulating monocytes and cardiac macrophages in diastolic dysfunction - WP4474 (Mus musculus)
- DDX1 as a regulatory component of the Drosha microprocessor - WP2942 (Homo sapiens)
- EV release from cardiac cells and their functional effects - WP3297 (Homo sapiens)
- Ectoderm differentiation - WP2858 (Homo sapiens)
- Endoderm differentiation - WP2853 (Homo sapiens)
- ErbB signaling pathway - WP673 (Homo sapiens)
- Extracellular vesicle-mediated signaling in recipient cells - WP2870 (Homo sapiens)
- Extracellular vesicles in the crosstalk of cardiac cells - WP4300 (Homo sapiens)
- FABP4 in ovarian cancer - WP4400 (Homo sapiens)
- Fluoropyrimidine activity - WP1601 (Homo sapiens)
- Genes targeted by miRNAs in adipocytes - WP1992 (Homo sapiens)
- Glioblastoma signaling pathways - WP2261 (Homo sapiens)
- H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity - WP3969 (Homo sapiens)
- Hepatitis C and hepatocellular carcinoma - WP3646 (Homo sapiens)
- Hypoxia-mediated EMT and stemness - WP2943 (Homo sapiens)
- IL1 and megakaryocytes in obesity - WP2865 (Homo sapiens)
- Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells - WP4301 (Homo sapiens)
- Interactions between immune cells and microRNAs in tumor microenvironment - WP4559 (Homo sapiens)
- MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement - WP4560 (Homo sapiens)
- MFAP5-mediated ovarian cancer cell motility and invasiveness - WP3301 (Homo sapiens)
- Mecp2 and associated Rett syndrome - WP2910 (Mus musculus)
- Mesodermal commitment pathway - WP2857 (Homo sapiens)
- Metastatic brain tumor - WP2249 (Homo sapiens)
- MicroRNA for targeting cancer growth and vascularization in glioblastoma - WP3593 (Homo sapiens)
- MicroRNA network associated with chronic lymphocytic leukemia - WP4399 (Homo sapiens)
- MicroRNAs in cardiomyocyte hypertrophy - WP1544 (Homo sapiens)
- Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors - WP4397 (Homo sapiens)
- OSX and miRNAs in tooth development - WP3971 (Homo sapiens)
- PDGFR-alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine - WP4398 (Mus musculus)
- Parkinson's disease - WP3638 (Mus musculus)
- Parkinson's disease pathway - WP2371 (Homo sapiens)
- Platelet-mediated interactions with vascular and circulating cells - WP4462 (Homo sapiens)
- RAC1/PAK1/p38/MMP2 pathway - WP3303 (Homo sapiens)
- SREBF and miR33 in cholesterol and lipid homeostasis - WP2011 (Homo sapiens)
- SRF and miRs in smooth muscle differentiation and proliferation - WP1991 (Homo sapiens)
- Spinal cord injury - WP2431 (Homo sapiens)
- T cell receptor and co-stimulatory signaling - WP2583 (Homo sapiens)
- TCA cycle nutrient use and invasiveness of ovarian cancer - WP2868 (Homo sapiens)
- Tgif disruption of Shh signaling - WP3674 (Homo sapiens)
- Translation inhibitors in chronically activated PDGFRA cells - WP4566 (Homo sapiens)
- Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer - WP4284 (Homo sapiens)
- eIF5A regulation in response to inhibition of the nuclear export system - WP3302 (Homo sapiens)
- exRNA mechanism of action and biogenesis - WP2805 (Homo sapiens)
- lncRNA in canonical Wnt signaling and colorectal cancer - WP4258 (Homo sapiens)
- lncRNA-mediated mechanisms of therapeutic resistance - WP3672 (Homo sapiens)
- miR-127 in mesendoderm differentiation - WP3991 (Mus musculus)
- miR-222 in exercise-induced cardiac growth - WP2928 (Mus musculus)
- miR-509-3p alteration of YAP1/ECM axis - WP3967 (Homo sapiens)
- miR-517 relationship with ARCN1 and USP1 - WP3596 (Homo sapiens)
- miR302-367 promoting cardiomyocyte proliferation - WP2904 (Mus musculus)
- miRNA biogenesis - WP2338 (Homo sapiens)
- miRNA regulation of DNA damage response - WP1530 (Homo sapiens)
- miRNA regulation of p53 pathway in prostate cancer - WP3982 (Homo sapiens)
- miRNA regulation of prostate cancer signaling pathways - WP3981 (Homo sapiens)
- miRNA role in immune response in sepsis - WP4329 (Homo sapiens)
- miRNA targets in ECM and membrane receptors - WP2911 (Homo sapiens)
- miRNAs involved in DNA damage response - WP1545 (Homo sapiens)
- mir-124 predicted interactions with cell cycle and differentiation - WP3595 (Homo sapiens)
- mir-193a and MVP in colon cancer metastasis - WP3979 (Mus musculus)
- mir219 in oligodendrocyte differentiation and myelination - WP2811 (Rattus norvegicus)
- ncRNAs involved in STAT3 signaling in hepatocellular carcinoma - WP4337 (Homo sapiens)
- ncRNAs involved in Wnt signaling in hepatocellular carcinoma - WP4336 (Homo sapiens)
Community Members
David Chen and Varduhi Petrosyan .
Authors of Community Pathways
David Chen , Varduhi Petrosyan , Nathan Salomonis , Thomas Kelder , Kristina Hanspers , Alex Pico , Jonathan Mélius , Egon Willighagen , Friederike Ehrhart , Lovnish Thakur , Susan Coort , Eric Weitz , Andika Tan , Zahra Roudbari , Samuel Sklar , Martijn Van Iersel , Martina Summer-Kutmon , Denise Slenter , Marvin Martens , Luigi Maiorana , Christine Chichester , Eric Jaehnig , Lauren J. Dupuis , Finterly Hu , Anders Riutta , Anwesha Bohler , Chris Evelo , Aaron Caine , Etaglobin , Daniela Digles , Elisson nl , Marianthi Kalafati , Elisa Cirillo , Lotte Sevenich , Mshel016 , Devi , Ryan Miller , Maartje Levels , Mick Eikelhof , Linda Rieswijk , Kathy Ivey , Deborah Micael , Mbrandon , AAR&Co , Andra Waagmeester , Jan Krumeich , Stan Gaj , Vanessa Sousa , and Max Van Son .