H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity (WP3969)
Homo sapiens
In this proposed model, H19 interacts with macroH2A, and this may consequently lead to de-repression of genes including CDK8, CDK4, and CCND1. Increased CDK4-cyclin D1 complex phosphorylates Rb to disrupt Rb-E2F1 interaction, leading to E2F1 activation. The increase of CDK8 expression enhances the function of mediator complex including MED1, and facilitates the gene regulation by β-catenin. These downstream targets could work in a synergistic way of promoting cell proliferation and increasing cell motility in CRC. Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264449/ Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3969 CPTAC Assay Portal]
Authors
Kristina Hanspers , Alex Pico , and Egon WillighagenActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
CPTACAnnotations
Disease Ontology
colorectal cancerLabel | Type | Compact Identifier | Comment |
---|---|---|---|
macroH2A | GeneProduct | ensembl:ENSG00000113648 | |
CDK4 | GeneProduct | ensembl:ENSG00000135446 | |
CTNNB1 | GeneProduct | ensembl:ENSG00000168036 | |
CCND1 | GeneProduct | ensembl:ENSG00000110092 | |
E2F1 | GeneProduct | ensembl:ENSG00000101412 | |
CDK8 | GeneProduct | ensembl:ENSG00000132964 | |
CDK8 | GeneProduct | ensembl:ENSG00000132964 | |
MED1 | GeneProduct | ensembl:ENSG00000125686 | |
CSRP2 | GeneProduct | ensembl:ENSG00000175183 | |
JAG1 | GeneProduct | ensembl:ENSG00000101384 | |
SOX4 | GeneProduct | ensembl:ENSG00000124766 | |
CDH1 | GeneProduct | ensembl:ENSG00000039068 | |
TULP3 | GeneProduct | ensembl:ENSG00000078246 | |
PMAIP1 | GeneProduct | ensembl:ENSG00000141682 | |
RB1 | GeneProduct | ensembl:ENSG00000139687 | |
E2F1 | GeneProduct | ensembl:ENSG00000101412 | |
RB1 | GeneProduct | ensembl:ENSG00000139687 |
References
- H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer. Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, et al. EBioMedicine. 2016 Nov;13:113–24. PubMed Europe PMC Scholia