OSX and miRNAs in tooth development (WP3971)

Homo sapiens

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Role of Osx and certain miRNAs in tooth development. A – The role of Osx in dentinogenesis is shown by its regulation on Dspp. B – Osx regulates the differentiation of cementoblasts through Wnt-β-catenin pathway. C – Fine-tuning role of miRNA in tooth development.

Authors

Kristina Hanspers , Anders Riutta , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

cementoblast odontoblast

Pathway Ontology

signaling pathway pertinent to development

Participants
Query Drugst.One

Label Type Compact Identifier Comment
lithium chloride Metabolite chebi:48607
MIR145 GeneProduct ensembl:ENSG00000276365
RUNX2 GeneProduct ensembl:ENSG00000124813
OSX GeneProduct ensembl:ENSG00000170374
KLF4 GeneProduct ensembl:ENSG00000136826
DMP1 GeneProduct ensembl:ENSG00000152592
DSPP GeneProduct ensembl:ENSG00000152591
BMP7 GeneProduct ensembl:ENSG00000101144
NOTCH1 GeneProduct ensembl:ENSG00000148400
NOTCH2 GeneProduct ensembl:ENSG00000134250
NOTCH3 GeneProduct ensembl:ENSG00000074181
NOTCH4 GeneProduct ensembl:ENSG00000204301
ALP GeneProduct ensembl:ENSG00000162551
DKK1 GeneProduct ensembl:ENSG00000107984
SOST GeneProduct ensembl:ENSG00000167941
TCF-1 GeneProduct ensembl:ENSG00000135100
CTNNB1 GeneProduct ensembl:ENSG00000168036
MIR338 GeneProduct ensembl:ENSG00000283604
MIR32 GeneProduct ensembl:ENSG00000207698
MIR586 GeneProduct ensembl:ENSG00000207769
MIR885 GeneProduct ensembl:ENSG00000216135
MIR29A GeneProduct ensembl:ENSG00000226380
MIR34A GeneProduct ensembl:ENSG00000228526
MIRLET7A1 GeneProduct ensembl:ENSG00000199165
MIR143 GeneProduct mirbase:MI0000459
MIR204 GeneProduct ensembl:ENSG00000207935
MIR211 GeneProduct ensembl:ENSG00000207702
MIRLET7A2 GeneProduct ensembl:ENSG00000198975
MIRLET7C GeneProduct ensembl:ENSG00000199030
MIRLET7D GeneProduct ensembl:ENSG00000199133
MIRLET7E GeneProduct ensembl:ENSG00000198972
MIRLET7F1 GeneProduct ensembl:ENSG00000199072
MIRLET7F2 GeneProduct ensembl:ENSG00000208012
MIRLET7G GeneProduct ensembl:ENSG00000199150
MIRLET7I GeneProduct ensembl:ENSG00000199179
MIR29B1 GeneProduct ncbigene:407024
MIR29B2 GeneProduct hgnc:31620

References

  1. Role of Osterix and MicroRNAs in Bone Formation and Tooth Development. Wang C, Liao H, Cao Z. Med Sci Monit. 2016 Aug 20;22:2934–42. PubMed Europe PMC Scholia