OSX and miRNAs in tooth development (WP3971)

Homo sapiens

Role of Osx and certain miRNAs in tooth development. A – The role of Osx in dentinogenesis is shown by its regulation on Dspp. B – Osx regulates the differentiation of cementoblasts through Wnt-β-catenin pathway. C – Fine-tuning role of miRNA in tooth development.


Kristina Hanspers , Anders Riutta , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens




Pathway Ontology

signaling pathway pertinent to development

Cell Type Ontology

odontoblast cementoblast


Label Type Compact URI Comment
Lithium chloride Metabolite chebi:48607
MIR145 GeneProduct ensembl:ENSG00000276365
RUNX2 GeneProduct ensembl:ENSG00000124813
OSX GeneProduct ensembl:ENSG00000170374
KLF4 GeneProduct ensembl:ENSG00000136826
DMP1 GeneProduct ensembl:ENSG00000152592
DSPP GeneProduct ensembl:ENSG00000152591
BMP7 GeneProduct ensembl:ENSG00000101144
NOTCH1 GeneProduct ensembl:ENSG00000148400
NOTCH2 GeneProduct ensembl:ENSG00000134250
NOTCH3 GeneProduct ensembl:ENSG00000074181
NOTCH4 GeneProduct ensembl:ENSG00000204301
ALP GeneProduct ensembl:ENSG00000162551
DKK1 GeneProduct ensembl:ENSG00000107984
SOST GeneProduct ensembl:ENSG00000167941
TCF-1 GeneProduct ensembl:ENSG00000135100
CTNNB1 GeneProduct ensembl:ENSG00000168036
MIR338 GeneProduct ensembl:ENSG00000283604
MIR32 GeneProduct ensembl:ENSG00000207698
MIR586 GeneProduct ensembl:ENSG00000207769
MIR885 GeneProduct ensembl:ENSG00000216135
MIR29A GeneProduct ensembl:ENSG00000226380
MIR34A GeneProduct ensembl:ENSG00000228526
MIRLET7A1 GeneProduct ensembl:ENSG00000199165
MIR143 GeneProduct mirbase:MI0000459
MIR204 GeneProduct ensembl:ENSG00000207935
MIR211 GeneProduct ensembl:ENSG00000207702
MIRLET7A2 GeneProduct ensembl:ENSG00000198975
MIRLET7C GeneProduct ensembl:ENSG00000199030
MIRLET7D GeneProduct ensembl:ENSG00000199133
MIRLET7E GeneProduct ensembl:ENSG00000198972
MIRLET7F1 GeneProduct ensembl:ENSG00000199072
MIRLET7F2 GeneProduct ensembl:ENSG00000208012
MIRLET7G GeneProduct ensembl:ENSG00000199150
MIRLET7I GeneProduct ensembl:ENSG00000199179
MIR29B1 GeneProduct ncbigene:407024
MIR29B2 GeneProduct hgnc:31620


  1. Role of Osterix and MicroRNAs in Bone Formation and Tooth Development. Wang C, Liao H, Cao Z. Med Sci Monit. 2016 Aug 20;22:2934–42. PubMed Europe PMC Scholia