ncRNAs involved in Wnt signaling in hepatocellular carcinoma (WP4336)

Homo sapiens

This pathway is based on the [[Pathway:WP428 | Wnt Signaling Pathway]] with information on lncRNA involvement in hepatocellular carcinoma from Fig 3 in Klingenberg et al. Phosphorylation sites were added based on information from PhosphoSitePlus (R),


Kristina Hanspers , Friederike Ehrhart , and Egon Willighagen


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Homo sapiens




Cell Type Ontology


Pathway Ontology

altered Wnt signaling pathway Wnt signaling, canonical pathway Wnt signaling pathway cancer pathway

Disease Ontology

hepatocellular carcinoma


Label Type Compact URI Comment
DVL3 GeneProduct ncbigene:1857
PLAU GeneProduct ncbigene:5328
FRAT1 GeneProduct ncbigene:10023
GSK3B GeneProduct ncbigene:2932 MOUSE:KG38 MOUSE
MIR214 GeneProduct hgnc.symbol:MIR214
CSNK2B GeneProduct ensembl:ENSG00000204435
APC GeneProduct ncbigene:324
WNT3A GeneProduct ncbigene:89780
FZD3 GeneProduct ncbigene:7976
LEF1 GeneProduct ensembl:ENSG00000138795
MIR1247 GeneProduct mirbase.mature:MIMAT0005899
CSNK1E GeneProduct ncbigene:1454
CCND1 GeneProduct ncbigene:595
FZD8 GeneProduct ncbigene:8325
TCF7L1 GeneProduct ensembl:ENSG00000152284
WNT7A GeneProduct ncbigene:7476
TCF7L2 GeneProduct ensembl:ENSG00000148737
WNT11 GeneProduct ncbigene:7481
SOX7 GeneProduct ensembl:ENSG00000171056
WNT1 GeneProduct ncbigene:7471
JUN GeneProduct ncbigene:3725
LRP5 GeneProduct ncbigene:4041
FZD10 GeneProduct ncbigene:11211
FZD7 GeneProduct ncbigene:8324
WNT5B GeneProduct ncbigene:81029
CTNNB1 GeneProduct ncbigene:1499
WNT2 GeneProduct ncbigene:7472
CSNK1A1 GeneProduct ensembl:ENSG00000113712
WNT2B GeneProduct ncbigene:7482
FZD4 GeneProduct ncbigene:6424
DVL2 GeneProduct ncbigene:1856
WNT6 GeneProduct ncbigene:7475
CCND3 GeneProduct ncbigene:896
WNT5A GeneProduct ncbigene:7474
ROR1 GeneProduct ncbigene:4919
FZD1 GeneProduct ncbigene:8321
LRP6 GeneProduct ncbigene:4040
KREM1 GeneProduct ncbigene:83999
WNT16 GeneProduct ncbigene:51384
FZD6 GeneProduct ncbigene:8323
MIR452 GeneProduct ensembl:ENSG00000283751
RYK GeneProduct ncbigene:6259
WNT4 GeneProduct ncbigene:54361
WNT3 GeneProduct ncbigene:7473
CSNK2A1 GeneProduct ensembl:ENSG00000101266
AXIN1 GeneProduct ncbigene:8312
WNT10B GeneProduct ncbigene:7480
FZD5 GeneProduct ncbigene:7855
WNT7B GeneProduct ncbigene:7477
DVL1 GeneProduct ncbigene:1855
CHD8 GeneProduct ensembl:ENSG00000100888
WNT10A GeneProduct ncbigene:80326
CSNK1A1L GeneProduct ensembl:ENSG00000180138
CSNK2A3 GeneProduct ensembl:ENSG00000254598
FOSL1 GeneProduct ncbigene:8061
MYC GeneProduct ncbigene:4609
CSNK2A2 GeneProduct ensembl:ENSG00000070770
CCND2 GeneProduct ncbigene:894
FZD9 GeneProduct ncbigene:8326
TCF7 GeneProduct ensembl:ENSG00000081059
WNT16 GeneProduct ncbigene:51384
FZD2 GeneProduct ncbigene:2535
ELAVL1 GeneProduct ensembl:ENSG00000066044
EZH2 GeneProduct ensembl:ENSG00000106462
ROR2 GeneProduct ncbigene:4920
CTNNB1 GeneProduct ncbigene:1499
CTNNB1 GeneProduct ncbigene:1499
DKK1 GeneProduct ensembl:ENSG00000107984
DKK2 GeneProduct ensembl:ENSG00000155011
DKK4 GeneProduct ensembl:ENSG00000104371
SOST GeneProduct ensembl:ENSG00000167941
SERPINF1 GeneProduct ensembl:ENSG00000132386
FRAT2 GeneProduct ensembl:ENSG00000181274
CTNNB1 GeneProduct ncbigene:1499
SFRP1 GeneProduct ensembl:ENSG00000104332
SFRP2 GeneProduct ensembl:ENSG00000145423
SFRP4 GeneProduct ensembl:ENSG00000106483
SFRP5 GeneProduct ensembl:ENSG00000120057
NOTUM GeneProduct ensembl:ENSG00000185269
CER1 GeneProduct ensembl:ENSG00000147869
WIF1 GeneProduct ensembl:ENSG00000156076
PORCN GeneProduct ensembl:ENSG00000102312
NKD1 GeneProduct ensembl:ENSG00000140807
NKD2 GeneProduct ensembl:ENSG00000145506
CXXC4 GeneProduct ensembl:ENSG00000168772
SENP2 GeneProduct ensembl:ENSG00000163904
NLK GeneProduct ensembl:ENSG00000087095
CTNNBIP1 GeneProduct ensembl:ENSG00000178585
SOX17 GeneProduct ensembl:ENSG00000164736
CTBP1 GeneProduct ensembl:ENSG00000159692
CTBP2 GeneProduct ensembl:ENSG00000175029
MIR15B GeneProduct mirbase.mature:MIMAT0000417
MIR195 GeneProduct mirbase.mature:MIMAT0000461
MTDH GeneProduct ensembl:ENSG00000147649
MIR18A GeneProduct ensembl:ENSG00000283815
KLF4 GeneProduct ensembl:ENSG00000136826
MIR320A GeneProduct ensembl:ENSG00000208037


  1. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia
  2. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia
  3. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets. Klingenberg M, Matsuda A, Diederichs S, Patel T. J Hepatol. 2017 Sep;67(3):603–18. PubMed Europe PMC Scholia
  4. Role of microRNAs in the main molecular pathways of hepatocellular carcinoma. Vasuri F, Visani M, Acquaviva G, Brand T, Fiorentino M, Pession A, et al. World J Gastroenterol. 2018 Jul 7;24(25):2647–60. PubMed Europe PMC Scholia