Extracellular vesicles in the crosstalk of cardiac cells (WP4300)

Homo sapiens

(A) FB-derived exosomes enriched with miR-21-3p or Spp1 and EGFR proteins are transferred to CMs, leading to CM hypertrophy. (B) EVs secreted from CMs or MSCs, as well as circulating EVs exert regulatory effects on CM apoptosis. (C) CM-derived exosomal HSP90 together with secreted IL-6 are able to activate STAT-3 signaling in cardiac FBs, leading to cardiac fibrosis; whereas CM-derived exosomes from exercised diabetic mice express high levels of miR-29b and miR-455, thus reducing cardiac fibrosis. (D) EVs secreted from CMs or MSCs are transferred to ECs, exerting pro- or anti-angiogenic activities. Description from Bei et al.


Kristina Hanspers , Anders Riutta , Egon Willighagen , and Martina Summer-Kutmon


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Homo sapiens




Cell Type Ontology

fibroblast of cardiac tissue cardiac endothelial cell cardiac muscle cell

Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
VEGFR2 GeneProduct ensembl:ENSG00000128052
PTEN GeneProduct ensembl:ENSG00000171862
HSPB1 GeneProduct ensembl:ENSG00000106211
MIR455 GeneProduct ensembl:ENSG00000207726
mir-19a GeneProduct ncbigene:406979
EGF GeneProduct ensembl:ENSG00000138798
CD63 GeneProduct ensembl:ENSG00000135404
mir-29b2 GeneProduct hgnc:31620
mir21-3p GeneProduct hgnc:31586
GATA4 GeneProduct ensembl:ENSG00000136574
SPP1 GeneProduct ensembl:ENSG00000118785
BIRC5 GeneProduct ensembl:ENSG00000089685
SORBS2 GeneProduct ensembl:ENSG00000154556
CD81 GeneProduct ensembl:ENSG00000110651
TLR4 GeneProduct ensembl:ENSG00000136869
SOD1 GeneProduct ensembl:ENSG00000142168
MMP9 GeneProduct ensembl:ENSG00000100985
STAT3 GeneProduct ensembl:ENSG00000168610
IL6 GeneProduct ensembl:ENSG00000136244
EGFR GeneProduct ensembl:ENSG00000146648
PDLIM5 GeneProduct ensembl:ENSG00000163110
MIR320A GeneProduct ensembl:ENSG00000208037
IGF1 GeneProduct ensembl:ENSG00000017427
ETS2 GeneProduct ensembl:ENSG00000157557
HSP20 GeneProduct ensembl:ENSG00000142168
mir-29b1 GeneProduct hgnc:31619


  1. Extracellular Vesicles in Cardiovascular Theranostics. Bei Y, Das S, Rodosthenous RS, Holvoet P, Vanhaverbeke M, Monteiro MC, et al. Theranostics. 2017 Sep 26;7(17):4168–82. PubMed Europe PMC Scholia