(A) FB-derived exosomes enriched with miR-21-3p or Spp1 and EGFR proteins are transferred to CMs, leading to CM hypertrophy. (B) EVs secreted from CMs or MSCs, as well as circulating EVs exert regulatory effects on CM apoptosis. (C) CM-derived exosomal HSP90 together with secreted IL-6 are able to activate STAT-3 signaling in cardiac FBs, leading to cardiac fibrosis; whereas CM-derived exosomes from exercised diabetic mice express high levels of miR-29b and miR-455, thus reducing cardiac fibrosis. (D) EVs secreted from CMs or MSCs are transferred to ECs, exerting pro- or anti-angiogenic activities.
Description from Bei et al.da0cardiac muscle cellCL:0000746Cell Ontologyfibroblast of cardiac tissueCL:0002548Cell Ontologycardiac endothelial cellCL:0010008Cell Ontology29158817PubMedExtracellular Vesicles in Cardiovascular Theranostics.Theranostics2017Bei YDas SRodosthenous RSHolvoet PVanhaverbeke MMonteiro MCMonteiro VVSRadosinska JBartekova MJansen FLi QRajasingh JXiao J