Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells (WP4301)
Schematic representation of inhibition of exosome biogenesis and secretion by Manumycin A (MA) in castration-resistant prostate cancer cells (CRPC) cells. The inhibition of Ras/Raf/ERK1/2 pathway by MA leads to transcriptional down-regulation of hnRNP H1. A decrease in hnRNP H1 transcripts leads to inhibition of exosome biogenesis and secretion by suppressing ALIX and Rab27a. Description from Datta et al.
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Disease Ontologyprostate cancer
Pathway OntologyRas family mediated signaling pathway
- Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, et al. Cancer Lett. 2017 Nov 1;408:73–81. PubMed Europe PMC Scholia