Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells (WP4301)

Homo sapiens

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Schematic representation of inhibition of exosome biogenesis and secretion by the antibiotic Manumycin A (MA) in castration-resistant prostate cancer cells (CRPC) cells. The inhibition of Ras/Raf/ERK1/2 pathway by MA leads to transcriptional down-regulation of hnRNP H1. A decrease in hnRNP H1 transcripts leads to inhibition of exosome biogenesis and secretion by suppressing ALIX and RAB27A. Description from Datta et al.

Authors

Kristina Hanspers and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

CPTAC ExRNA

Annotations

Disease Ontology

prostate cancer

Pathway Ontology

drug pathway Ras family mediated signaling pathway

Cell Type Ontology

neoplastic cell

Participants
Query Drugst.One

Label Type Compact URI Comment
Manumycin A Metabolite chebi:29623
RAB27A GeneProduct ensembl:ENSG00000069974
ARAF GeneProduct ensembl:ENSG00000078061
MAPK1 GeneProduct ensembl:ENSG00000100030
ALIX GeneProduct ensembl:ENSG00000170248
HNRNPH1 GeneProduct ensembl:ENSG00000169045
BRAF GeneProduct ensembl:ENSG00000157764
RAF1 GeneProduct ensembl:ENSG00000132155
RRAS GeneProduct ensembl:ENSG00000126458
RRAS2 GeneProduct ensembl:ENSG00000133818
MRAS GeneProduct ensembl:ENSG00000158186
HRAS GeneProduct ensembl:ENSG00000174775
KRAS GeneProduct ensembl:ENSG00000133703
NRAS GeneProduct ensembl:ENSG00000213281
MAPK3 GeneProduct ensembl:ENSG00000102882
RAB5A GeneProduct ensembl:ENSG00000144566
RAB5B GeneProduct ensembl:ENSG00000111540
RAB5C GeneProduct ensembl:ENSG00000108774
HGS GeneProduct ensembl:ENSG00000185359

References

  1. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, et al. Cancer Lett. 2017 Nov 1;408:73–81. PubMed Europe PMC Scholia