Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells (WP4301)

Homo sapiens

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Schematic representation of inhibition of exosome biogenesis and secretion by Manumycin A (MA) in castration-resistant prostate cancer cells (CRPC) cells. The inhibition of Ras/Raf/ERK1/2 pathway by MA leads to transcriptional down-regulation of hnRNP H1. A decrease in hnRNP H1 transcripts leads to inhibition of exosome biogenesis and secretion by suppressing ALIX and Rab27a. Description from Datta et al.

Authors

Kristina Hanspers

Activity

last edited

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Disease Ontology

prostate cancer

Pathway Ontology

Ras family mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact Identifier Comment
RAB27A GeneProduct ensembl:ENSG00000069974
ARAF GeneProduct ensembl:ENSG00000078061
MAPK1 GeneProduct ensembl:ENSG00000100030
ALIX GeneProduct ensembl:ENSG00000170248
HNRNPH1 GeneProduct ensembl:ENSG00000169045
BRAF GeneProduct ensembl:ENSG00000157764
RAF1 GeneProduct ensembl:ENSG00000132155
RRAS GeneProduct ensembl:ENSG00000126458
RRAS2 GeneProduct ensembl:ENSG00000133818
MRAS GeneProduct ensembl:ENSG00000158186
HRAS GeneProduct ensembl:ENSG00000174775
KRAS GeneProduct ensembl:ENSG00000133703
NRAS GeneProduct ensembl:ENSG00000213281
MAPK3 GeneProduct ensembl:ENSG00000102882
RAB5A GeneProduct ensembl:ENSG00000144566
RAB5B GeneProduct ensembl:ENSG00000111540
RAB5C GeneProduct ensembl:ENSG00000108774
HGS GeneProduct ensembl:ENSG00000185359
RRAS GeneProduct ensembl:ENSG00000126458
RRAS2 GeneProduct ensembl:ENSG00000133818
MRAS GeneProduct ensembl:ENSG00000158186
HRAS GeneProduct ensembl:ENSG00000174775
KRAS GeneProduct ensembl:ENSG00000133703
NRAS GeneProduct ensembl:ENSG00000213281
ALIX GeneProduct ensembl:ENSG00000170248
RAB27A GeneProduct ensembl:ENSG00000069974

References

  1. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, et al. Cancer Lett. 2017 Nov 1;408:73–81. PubMed Europe PMC Scholia