Apoptosis-related network due to altered Notch3 in ovarian cancer (WP2864)

Homo sapiens

Results of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2864 CPTAC Assay Portal]


Kristina Hanspers , Zahra Roudbari , and Friederike Ehrhart


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Homo sapiens




Disease Ontology

reproductive organ cancer

Pathway Ontology

apoptotic cell death pathway cancer pathway


Label Type Compact URI Comment
NET1 GeneProduct ncbigene:10276
ERBB3 GeneProduct ncbigene:2065
TNF GeneProduct ncbigene:7124
SERBP1 GeneProduct ncbigene:26135
APOE GeneProduct ncbigene:348
CUL5 GeneProduct ncbigene:8065
SQSTM1 GeneProduct ncbigene:8878
TNFRSF10B GeneProduct ncbigene:8795
RIPK2 GeneProduct ncbigene:8767
CUL1 GeneProduct ncbigene:8454
CDKN1A GeneProduct ncbigene:1026
AKT1 GeneProduct ncbigene:207
HSPB1 GeneProduct ncbigene:3315
CTNNA1 GeneProduct ncbigene:1495
HSPD1 GeneProduct ncbigene:3329
HELLS GeneProduct ncbigene:3070
ANXA5 GeneProduct ncbigene:308
HDAC1 GeneProduct ncbigene:3065
NFKB1 GeneProduct ncbigene:4790
TRAF1 GeneProduct ncbigene:7185
NGFRAP1 GeneProduct ncbigene:27018
RNF7 GeneProduct ncbigene:9616
PTK2 GeneProduct ncbigene:5747
ETS1 GeneProduct ncbigene:2113
MAPK1 GeneProduct ncbigene:5594
CDKN1B GeneProduct ncbigene:1027
RPS6KB1 GeneProduct ncbigene:6198
AXIN1 GeneProduct ncbigene:8312
SMAD7 GeneProduct ncbigene:4092
VIM GeneProduct ncbigene:7431
PKN1 GeneProduct ncbigene:5585
IER3 GeneProduct ncbigene:8870
CSDA GeneProduct ncbigene:8531
CARD14 GeneProduct ncbigene:79092
NQO1 GeneProduct ncbigene:1728
GCLC GeneProduct ncbigene:2729
JUND GeneProduct ncbigene:3727
F2R GeneProduct ncbigene:2149
BIRC5 GeneProduct ncbigene:332
THBS1 GeneProduct ncbigene:7057
TNFRSF21 GeneProduct ncbigene:27242
APP GeneProduct ncbigene:351
CASP7 GeneProduct ncbigene:840
NRG1 GeneProduct ncbigene:3084
ABL1 GeneProduct ncbigene:25
PAK2 GeneProduct ncbigene:5062
SOCS3 GeneProduct ncbigene:9021
IL7R GeneProduct ncbigene:3575
PTK2B GeneProduct ncbigene:2185
VAV3 GeneProduct ncbigene:10451
ERN1 GeneProduct ncbigene:2081
HSPA5 GeneProduct ncbigene:3309
BCL3 Protein ncbigene:602


  1. Notch3 pathway alterations in ovarian cancer. Hu W, Liu T, Ivan C, Sun Y, Huang J, Mangala LS, et al. Cancer Res. 2014 Jun 15;74(12):3282–93. PubMed Europe PMC Scholia