EV release from cardiac cells and their functional effects (WP3297)

Homo sapiens

Summary of reported extracellular vesicle (EV) release from cardiac cells in culture and their functional effects. EV release has been reported in numerous cell lines and primary cultures, both at baseline and in response to stimuli. Transfer of EVs between cell types has been demonstrated as well as delivery of cargo. Note that this pathway represents a review of multiple studies in multiple organisms. This pathway displays the human orthologs. HUVEC: human aortic endothelial cell HMEC-1: human microvascular endothelial cell HASMC: human aortic smooth muscle cell NRVM: neonatal rat ventricular myocyte. Adapted from Danielson KM, Das S. Extracellular Vesicles in Heart Disease: Excitement for the Future? Exosomes Microvesicles, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25429310


Kristina Hanspers , Susan Coort , Alex Pico , Marvin Martens , and Eric Weitz


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Homo sapiens




Pathway Ontology

regulatory pathway

Cell Type Ontology

endothelial cell fibroblast monocyte cardiac muscle cell


Label Type Compact URI Comment
Homocysteine Metabolite hmdb:HMDB0000742
Ox-LDL Metabolite chebi:60151
Ethanol Metabolite hmdb:HMDB0000108
Ethanol Metabolite hmdb:HMDB0000108
ERBB4 GeneProduct ensembl:ENSG00000178568
MIR143 GeneProduct ensembl:ENSG00000284182
KLF2 GeneProduct ensembl:ENSG00000127528
CXCL12 GeneProduct ensembl:ENSG00000107562
Prolactin GeneProduct ensembl:ENSG00000172179
RGS16 GeneProduct ensembl:ENSG00000143333
C-Myb GeneProduct ensembl:ENSG00000118513
hsa-miR-145-5p GeneProduct mirbase.mature:MIMAT0000437


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