RAC1/PAK1/p38/MMP2 pathway (WP3303)

Homo sapiens

Interplay of RAC1, p38 MAPK, PAK1 and MMP2 in cell signaling pathways downstream of TEK receptor activity related to tumor growth, angiogenesis, and cell proliferation. These processes are reduced in RAC1 inactivated models of ovarian cancer. Gonzalez-Villasana, et al. Clin Cancer Res, 2015. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3303 CPTAC Assay Portal]


Kristina Hanspers , Susan Coort , Linda Rieswijk , Alex Pico , Friederike Ehrhart , Eric Weitz , and Egon Willighagen


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Homo sapiens




Pathway Ontology

disease pathway cancer pathway signaling pathway

Disease Ontology

ovarian cancer


Label Type Compact URI Comment
PIP3 Metabolite hmdb:HMDB0004249
PIP2 Metabolite cas:245126-95-8
STAT5A GeneProduct ensembl:ENSG00000126561
IKK2 GeneProduct ensembl:ENSG00000104365
MAPK11 GeneProduct ensembl:ENSG00000185386
TEK GeneProduct ensembl:ENSG00000120156
ANG1 GeneProduct ensembl:ENSG00000154188
ERK1 GeneProduct ensembl:ENSG00000102882
NCK1 GeneProduct ensembl:ENSG00000158092
FN1 GeneProduct ensembl:ENSG00000115414
MAPK14 GeneProduct ensembl:ENSG00000112062
ABIN-1 GeneProduct ensembl:ENSG00000145901
MAPK1 GeneProduct ensembl:ENSG00000100030
ANG3 GeneProduct ensembl:ENSG00000116194
ERK2 GeneProduct ensembl:ENSG00000100030
HRAS GeneProduct ensembl:ENSG00000174775
SHP2 GeneProduct ensembl:ENSG00000179295
RAC1 GeneProduct ensembl:ENSG00000136238
PI3K/p110 GeneProduct ensembl:ENSG00000121879
ERK2 GeneProduct ensembl:ENSG00000100030
MAPK13 GeneProduct ensembl:ENSG00000156711
STAT3 GeneProduct ensembl:ENSG00000168610
ERK1 GeneProduct ensembl:ENSG00000102882
NFKB1 GeneProduct ensembl:ENSG00000109320
PIK3R GeneProduct ensembl:ENSG00000145675
AKT GeneProduct ensembl:ENSG00000142208
IKK1 GeneProduct ensembl:ENSG00000213341
GRB7 GeneProduct ensembl:ENSG00000141738
BAD GeneProduct ensembl:ENSG00000002330
IKBKG GeneProduct ensembl:ENSG00000269335
Survivin GeneProduct ensembl:ENSG00000089685
PAK1 GeneProduct ensembl:ENSG00000149269
NOS1 GeneProduct ensembl:ENSG00000089250
TP53 GeneProduct ensembl:ENSG00000141510
ABIN-3 GeneProduct ensembl:ENSG00000050730
IKB GeneProduct ensembl:ENSG00000100906
BAX GeneProduct ensembl:ENSG00000087088
YAP1 GeneProduct ensembl:ENSG00000137693
MAPK12 GeneProduct ensembl:ENSG00000188130
PIK3/p85 GeneProduct ensembl:ENSG00000145675
RS1 GeneProduct ensembl:ENSG00000102104
ABIN-2 GeneProduct ensembl:ENSG00000168884
DOKR GeneProduct ensembl:ENSG00000147443
JNK GeneProduct ensembl:ENSG00000107643
SAPK GeneProduct ncbigene:5601
STMN1 GeneProduct ensembl:ENSG00000117632
MYC GeneProduct ensembl:ENSG00000136997
CASP9 GeneProduct ensembl:ENSG00000132906
SOS1 GeneProduct ensembl:ENSG00000115904
MAPK14 GeneProduct ensembl:ENSG00000112062
RAD51 GeneProduct ensembl:ENSG00000051180
SRC GeneProduct ensembl:ENSG00000197122
NRAS GeneProduct ensembl:ENSG00000213281
EGFR GeneProduct ensembl:ENSG00000146648
EIF4EBP1 GeneProduct ensembl:ENSG00000187840
MAPK8 GeneProduct ensembl:ENSG00000107643
Integrin GeneProduct ensembl:ENSG00000150093
RasGAP GeneProduct ensembl:ENSG00000145715
GRB14 GeneProduct ensembl:ENSG00000115290
CTNNB1 GeneProduct ensembl:ENSG00000168036
TIE1 GeneProduct ensembl:ENSG00000066056
ANG4 GeneProduct ensembl:ENSG00000101280
PXN GeneProduct ensembl:ENSG00000089159
MSH2 GeneProduct ensembl:ENSG00000095002
ERBB2 GeneProduct ensembl:ENSG00000141736
KRAS GeneProduct ensembl:ENSG00000133703
CASP7 GeneProduct ensembl:ENSG00000165806
RELA GeneProduct ensembl:ENSG00000173039
FKHR GeneProduct ensembl:ENSG00000150907
ANG2 GeneProduct ensembl:ENSG00000091879
GRB2 GeneProduct ensembl:ENSG00000177885
CRK GeneProduct ensembl:ENSG00000167193
PAK1 GeneProduct ensembl:ENSG00000149269
STAT5B GeneProduct ensembl:ENSG00000173757
NFKB1 GeneProduct ensembl:ENSG00000109320
IKB GeneProduct ensembl:ENSG00000100906
FAK GeneProduct ensembl:ENSG00000169398
NOS2 GeneProduct ensembl:ENSG00000007171
MMP2 GeneProduct ensembl:ENSG00000087245


  1. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. Gonzalez-Villasana V, Fuentes-Mattei E, Ivan C, Dalton HJ, Rodriguez-Aguayo C, Fernandez-de Thomas RJ, et al. Clin Cancer Res. 2015 May 1;21(9):2127–37. PubMed Europe PMC Scholia