lncRNA-mediated mechanisms of therapeutic resistance (WP3672)

Homo sapiens

LncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival signaling pathways, cell cycle progression and DNA repair, sensitization to apoptosis, and modulation of intercellular communication mediated by extracellular vesicles. This pathway is based on Fig 6 from Parasramka et al: http://www.ncbi.nlm.nih.gov/pubmed/27013343 Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3672 CPTAC Assay Portal]


Kristina Hanspers , Alex Pico , Friederike Ehrhart , Eric Weitz , and Egon Willighagen


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Homo sapiens




Pathway Ontology

long non-coding RNA pathway antineoplastic drug pathway cancer pathway

Disease Ontology

hepatocellular carcinoma


Label Type Compact URI Comment
WNT6 GeneProduct ensembl:ENSG00000115596
HIF1A GeneProduct ensembl:ENSG00000100644
P-gp GeneProduct ensembl:ENSG00000085563
Bcl-xl GeneProduct ensembl:ENSG00000171552
TP53 GeneProduct ensembl:ENSG00000141510
p21 GeneProduct ensembl:ENSG00000124762


  1. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma. Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T. Pharmacol Ther. 2016 May;161:67–78. PubMed Europe PMC Scholia