miR-127 in mesendoderm differentiation (WP3991)

Mus musculus

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Schematic representation depicts the mechanism of miR-127 in accelerating mesendoderm differentiation. miR-127, through the complementary pairing, suppresses the expression of Lefty2, which is referred to as antagonist to the nodal pathway. Thus, miR-127 induces p-Smad2 expression and finally up-regulates expression of mesendoderm markers.

Authors

Kristina Hanspers

Activity

last edited

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Organisms

Mus musculus

Communities

ExRNA

Annotations

Cell Type Ontology

embryonic stem cell

Pathway Ontology

signaling pathway pertinent to development

Participants

Label Type Compact URI Comment
Lefty2 GeneProduct ensembl:ENSMUSG00000066652
Mir127 GeneProduct ensembl:ENSMUSG00000070076
Acvr1 GeneProduct ensembl:ENSMUSG00000026836
Cfc1 GeneProduct ensembl:ENSMUSG00000026124
Smad2 GeneProduct ensembl:ENSMUSG00000024563
Nodal GeneProduct ensembl:ENSMUSG00000037171
Acvr2a GeneProduct ensembl:ENSMUSG00000052155
Smad2 GeneProduct ensembl:ENSMUSG00000024563
Smad4 GeneProduct ensembl:ENSMUSG00000024515
Smad2 GeneProduct ensembl:ENSMUSG00000024563
Smad4 GeneProduct ensembl:ENSMUSG00000024515
Smad4 GeneProduct ensembl:ENSMUSG00000024515
Smad2 GeneProduct ensembl:ENSMUSG00000024563
Foxa2 GeneProduct ensembl:ENSMUSG00000037025
T GeneProduct ncbigene:20997

References

  1. MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2. Ma H, Lin Y, Zhao ZA, Lu X, Yu Y, Zhang X, et al. J Biol Chem. 2016 Jun 3;291(23):12126–35. PubMed Europe PMC Scholia