miRNA biogenesis (WP2338)

Homo sapiens

microRNA biogenesis + an example of a miRBase entry. As an example immature hsa-mir-146a is shown Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2338 CPTAC Assay Portal].


Susan Coort , Alex Pico , Friederike Ehrhart , Marvin Martens , Kristina Hanspers , and Eric Weitz


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Homo sapiens




Pathway Ontology

classic metabolic pathway microRNA pathway


Label Type Compact URI Comment
GTP Metabolite hmdb:HMDB0001440
RAN GeneProduct ncbigene:5901
XPO5 GeneProduct ensembl:ENSG00000124571
DROSHA GeneProduct ensembl:ENSG00000113360
DICER1 GeneProduct ensembl:ENSG00000100697
DGCR8 GeneProduct ensembl:ENSG00000128191
DICER1 GeneProduct ensembl:ENSG00000100697
TRBP Protein uniprot:Q15633


  1. MicroRNA function in animal development. Wienholds E, Plasterk RHA. FEBS Lett. 2005 Oct 31;579(26):5911–22. PubMed Europe PMC Scholia
  2. Widespread regulatory activity of vertebrate microRNA* species. Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, et al. RNA. 2011 Feb;17(2):312–26. PubMed Europe PMC Scholia