miRNA regulation of prostate cancer signaling pathways (WP3981)

Homo sapiens

Diagrammatic scheme depicting potential survival pathway-related gene targets of the downregulated microRNAs and their signaling pathways in prostate cancer cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed to predict potential targets of a subset of highly downregulated miRNAs (>2-fold) in prostate tumors. Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3: http://journals.sagepub.com/doi/suppl/10.1177/1535370216681554.


Kristina Hanspers , Egon Willighagen , Max Van Son , and Friederike Ehrhart


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens




Disease Ontology

prostate cancer

Pathway Ontology

cancer pathway


Label Type Compact URI Comment
DNA Metabolite chebi:16991
PIP3 Metabolite chebi:16618
DNA Metabolite chebi:16991
DNA Metabolite chebi:16991
DNA Metabolite chebi:16991
MAP2K1 GeneProduct ensembl:ENSG00000169032
CREBBP GeneProduct ensembl:ENSG00000005339
NFKB1 GeneProduct ensembl:ENSG00000109320
PDGFA GeneProduct ensembl:ENSG00000197461
AR GeneProduct ncbigene:367
TP53 GeneProduct ensembl:ENSG00000141510
NFKBIA GeneProduct ensembl:ENSG00000100906
BCL2 GeneProduct ensembl:ENSG00000171791
PSA GeneProduct ensembl:ENSG00000142515
CCND1 GeneProduct ensembl:ENSG00000110092
PDGFRB GeneProduct ensembl:ENSG00000113721
PIK3CA GeneProduct ensembl:ENSG00000121879
GRB2 GeneProduct ensembl:ENSG00000177885
SOS1 GeneProduct ensembl:ENSG00000115904
KRAS GeneProduct ensembl:ENSG00000133703
RAF1 GeneProduct ensembl:ENSG00000132155
MAPK1 GeneProduct ensembl:ENSG00000100030
AKT3 GeneProduct ensembl:ENSG00000117020
CASP9 GeneProduct ensembl:ENSG00000132906
BAD GeneProduct ensembl:ENSG00000002330
FOXO1 GeneProduct ensembl:ENSG00000150907
CDKN1A GeneProduct ensembl:ENSG00000124762
CDKN1B GeneProduct ensembl:ENSG00000111276
MDM2 GeneProduct ensembl:ENSG00000135679
GSK3B GeneProduct ensembl:ENSG00000082701
IKBKG GeneProduct ensembl:ENSG00000269335
MTOR GeneProduct ensembl:ENSG00000198793
AR GeneProduct ncbigene:367
CREB3L1 GeneProduct ensembl:ENSG00000157613
CTNNB1 GeneProduct ensembl:ENSG00000168036
TCF7 GeneProduct ensembl:ENSG00000081059
MAP2K2 GeneProduct ensembl:ENSG00000126934


  1. Identification of microRNA signature and potential pathway targets in prostate cancer. Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, et al. Exp Biol Med (Maywood). 2017 Mar;242(5):536–46. PubMed Europe PMC Scholia