MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement (WP4560)

Homo sapiens

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Proposed signaling pathways by which MFAP5 induces LPP expression and increases the permeability and motility of endothelial cells via cytoskeleton rearrangement. The activation of the MFAP5-mediated signaling cascade in endothelial cells up-regulates LPP expression and subsequently promotes the motility of endothelial cells and the permeability of the endothelial cell monolayer. Adapted from supplemental figure 11 from [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785271/ Leung et al].

Authors

Kristina Hanspers , Friederike Ehrhart , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC ExRNA

Annotations

Cell Type Ontology

endothelial cell fibroblast

Disease Ontology

ovarian cancer

Pathway Ontology

cancer pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
ITPR1 GeneProduct ensembl:ENSG00000150995
TJP1 GeneProduct ensembl:ENSG00000104067
ITGAV GeneProduct ensembl:ENSG00000138448
MYL2 GeneProduct ensembl:ENSG00000111245
PTK2 GeneProduct ensembl:ENSG00000169398
MAPK1 GeneProduct ensembl:ENSG00000100030
JUN GeneProduct ensembl:ENSG00000177606
MYLK GeneProduct ensembl:ENSG00000065534
MFAP5 GeneProduct ensembl:ENSG00000197614
VCL GeneProduct ensembl:ENSG00000035403
ITGB3 GeneProduct ensembl:ENSG00000259207
PTK2 GeneProduct ensembl:ENSG00000169398
LPP GeneProduct ensembl:ENSG00000145012
ACTN1 GeneProduct ensembl:ENSG00000072110
CREB1 GeneProduct ensembl:ENSG00000118260
CREB1 GeneProduct ensembl:ENSG00000118260
CREB1 GeneProduct ensembl:ENSG00000118260
LPP GeneProduct ensembl:ENSG00000145012
MAPK3 GeneProduct ensembl:ENSG00000102882
MAPK1 GeneProduct ensembl:ENSG00000100030
MAPK3 GeneProduct ensembl:ENSG00000102882
PXN GeneProduct ensembl:ENSG00000089159
LPP GeneProduct ensembl:ENSG00000145012
ACTN1 GeneProduct ensembl:ENSG00000072110
PLCG1 GeneProduct ensembl:ENSG00000124181
PLCG1 GeneProduct ensembl:ENSG00000124181
PRKCQ GeneProduct ensembl:ENSG00000065675
PRKCQ GeneProduct ensembl:ENSG00000065675
ITGAV GeneProduct ensembl:ENSG00000138448
ITGB3 GeneProduct ensembl:ENSG00000259207
TJP1 GeneProduct ensembl:ENSG00000104067
LPP GeneProduct ensembl:ENSG00000145012
ACTN1 GeneProduct ensembl:ENSG00000072110

References

  1. Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance. Leung CS, Yeung TL, Yip KP, Wong KK, Ho SY, Mangala LS, et al. J Clin Invest. 2018 Feb 1;128(2):589–606. PubMed Europe PMC Scholia