mir-124 predicted interactions with cell cycle and differentiation (WP3595)

Homo sapiens

Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.


Kristina Hanspers , Ryan Miller , and Martina Summer-Kutmon


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Homo sapiens




Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
SIX4 GeneProduct ensembl:ENSG00000100625
STRADB GeneProduct ensembl:ENSG00000082146
KLB1 GeneProduct ensembl:ENSG00000118046
AMPK GeneProduct ensembl:ENSG00000132356
PTBP GeneProduct ensembl:ENSG00000011304
SCP1 GeneProduct ensembl:ENSG00000144579


  1. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, et al. Mol Syst Biol. 2015 Dec 11;11(12):842. PubMed Europe PMC Scholia