ncRNAs involved in STAT3 signaling in hepatocellular carcinoma (WP4337)

Homo sapiens

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This pathway describes the influence of ncRNAs on the STAT3 pathway in hepatocellular carcinoma. The model is based on Fig 4 in Klingenberg et al.

Authors

Kristina Hanspers and Friederike Ehrhart

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC ExRNA

Annotations

Disease Ontology

hepatocellular carcinoma

Pathway Ontology

altered Jak-Stat signaling pathway cancer pathway

Cell Type Ontology

hepatocyte

Participants
Query Drugst.One

Label Type Compact URI Comment
JAK1 GeneProduct ensembl:ENSG00000162434
RELA GeneProduct ensembl:ENSG00000173039
IL6 GeneProduct ensembl:ENSG00000136244
IL6ST GeneProduct ensembl:ENSG00000134352
NFKB1 GeneProduct ensembl:ENSG00000109320
MIR21 GeneProduct ensembl:ENSG00000284190
IL11RA GeneProduct ensembl:ENSG00000137070
STAT3 GeneProduct ensembl:ENSG00000168610
IL11 GeneProduct ensembl:ENSG00000095752
IL6R GeneProduct ensembl:ENSG00000160712
JAK2 GeneProduct ensembl:ENSG00000096968
JAK3 GeneProduct ensembl:ENSG00000105639
JAK1 GeneProduct ensembl:ENSG00000162434
JAK2 GeneProduct ensembl:ENSG00000096968
JAK3 GeneProduct ensembl:ENSG00000105639
IL6 GeneProduct ensembl:ENSG00000136244
IL11 GeneProduct ensembl:ENSG00000095752
STAT3 GeneProduct ensembl:ENSG00000168610
ZEB1 GeneProduct ensembl:ENSG00000148516
SOX4 GeneProduct ensembl:ENSG00000124766
MIR200A GeneProduct ensembl:ENSG00000207607
MIR200B GeneProduct ensembl:ENSG00000207730
MIR200C GeneProduct ensembl:ENSG00000207713
MIR21 GeneProduct ensembl:ENSG00000284190
SOX4 GeneProduct ensembl:ENSG00000124766
UCA1 GeneProduct ensembl:ENSG00000214049
IL6 GeneProduct ensembl:ENSG00000136244

References

  1. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets. Klingenberg M, Matsuda A, Diederichs S, Patel T. J Hepatol. 2017 Sep;67(3):603–18. PubMed Europe PMC Scholia