Metastatic brain tumor (WP2249)

Homo sapiens

Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis. Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC, E2F3 and cyclin-dependent kinase(CDK6). Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Devi , Egon Willighagen , Kristina Hanspers , Elisa Cirillo , and Martina Summer-Kutmon


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Homo sapiens


Diseases ExRNA


Pathway Ontology

disease pathway

Disease Ontology

disease of cellular proliferation


Label Type Compact URI Comment
E2F3 GeneProduct ensembl:ENSG00000112242
TP53 GeneProduct ensembl:ENSG00000141510
CDC42 GeneProduct ensembl:ENSG00000070831
MIR29A GeneProduct ensembl:ENSG00000284033
CDK6 GeneProduct ensembl:ENSG00000105810
MYC GeneProduct ensembl:ENSG00000136997
MIRLET7A1 GeneProduct ensembl:ENSG00000199165
MIR29C GeneProduct ensembl:ENSG00000284214
MIRLET7A3 GeneProduct ensembl:ENSG00000198986
MIRLET7C GeneProduct ensembl:ENSG00000199030
MIRLET7D GeneProduct ensembl:ENSG00000199133
MIRLET7E GeneProduct ensembl:ENSG00000198972
MIRLET7F1 GeneProduct ensembl:ENSG00000199072
MIRLET7G GeneProduct ensembl:ENSG00000199150
P85A_HUMAN Protein uniprot:P27986


  1. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia
  2. The miR-34 family in cancer and apoptosis. Hermeking H. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia
  3. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, et al. Cell Death Differ. 2010 Feb;17(2):236–45. PubMed Europe PMC Scholia
  4. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, et al. Cell. 2010 Apr 2;141(1):129–41. PubMed Europe PMC Scholia