miRNAs involved in DNA damage response (WP1545)

Homo sapiens

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MicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo sapiens)". More info can be found there. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1545 CPTAC Assay Portal].

Authors

Jan Krumeich , Kristina Hanspers , Martijn Van Iersel , Andra Waagmeester , Martina Summer-Kutmon , Egon Willighagen , and Susan Coort

Activity

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Cited In

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

DNA repair pathway microRNA pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
hsa-mir-18a GeneProduct ensembl:ENSG00000283815
hsa-mir-371 GeneProduct ensembl:ENSG00000199031
E2F1 GeneProduct ncbigene:1869
c-Myc GeneProduct ncbigene:4609
hsa-let-7f GeneProduct ensembl:ENSG00000199072
ATM GeneProduct ncbigene:472
hsa-mir-542 GeneProduct ensembl:ENSG00000207784
hsa-mir-449c GeneProduct mirbase:MI0003823
hsa-let-7d GeneProduct ensembl:ENSG00000199133
hsa-mir-106b GeneProduct ensembl:ENSG00000208036
hsa-mir-3074 GeneProduct mirbase:MI0014181
c-Myc GeneProduct ncbigene:4609
hsa-mir-372 GeneProduct ensembl:ENSG00000199095
hsa-mir-424 GeneProduct ensembl:ENSG00000284231
hsa-mir-223 GeneProduct ensembl:ENSG00000284567
hsa-mir-29b-1 GeneProduct ensembl:ENSG00000283797
hsa-mir-210 GeneProduct ensembl:ENSG00000199038
hsa-mir-24 GeneProduct ensembl:ENSG00000207617
hsa-mir-374b GeneProduct ensembl:ENSG00000212027
hsa-mir-450b GeneProduct ensembl:ENSG00000216001
ABL1 GeneProduct ncbigene:25
CDK6 GeneProduct ncbigene:1021
hsa-mir-27b GeneProduct ensembl:ENSG00000207864
CDKN1A GeneProduct ncbigene:1026
hsa-mir-143 GeneProduct ensembl:ENSG00000284182
CCND1 GeneProduct ncbigene:595
hsa-mir-29c GeneProduct ensembl:ENSG00000284214
hsa-mir-23a GeneProduct ensembl:ENSG00000207980
hsa-mir-15a GeneProduct ensembl:ENSG00000283785
CCNE1 GeneProduct ncbigene:898
hsa-mir-503 GeneProduct ensembl:ENSG00000208005
hsa-mir-195 GeneProduct ensembl:ENSG00000284112
hsa-mir-450a GeneProduct ensembl:ENSG00000207755
hsa-let-7a GeneProduct ensembl:ENSG00000199165
hsa-mir-16 GeneProduct ensembl:ENSG00000208006
hsa-mir-21 GeneProduct ensembl:ENSG00000284190
hsa-mir-25 GeneProduct ensembl:ENSG00000207547
CDKN1B GeneProduct ncbigene:1027
hsa-mir-221 GeneProduct ensembl:ENSG00000207870
hsa-mir-19a GeneProduct ensembl:ENSG00000284204
hsa-mir-181a GeneProduct ensembl:ENSG00000207759
H2AFX GeneProduct ncbigene:3014
hsa-mir-93 GeneProduct ensembl:ENSG00000207757
hsa-mir-29a GeneProduct ensembl:ENSG00000284032
CCND3 GeneProduct ncbigene:896
hsa-mir-181b GeneProduct ensembl:ENSG00000207975
hsa-mir-100 GeneProduct ensembl:ENSG00000207994
hsa-mir-203 GeneProduct ensembl:ENSG00000207568
hsa-mir-145 GeneProduct ensembl:ENSG00000276365
hsa-mir-34b GeneProduct ensembl:ENSG00000207811
hsa-mir-19b-1 GeneProduct ensembl:ENSG00000284375
CREB1 GeneProduct ncbigene:1385
hsa-let-7b GeneProduct ensembl:ENSG00000284520
hsa-mir-373 GeneProduct ensembl:ENSG00000199143
hsa-mir-34c GeneProduct ensembl:ENSG00000207562
hsa-mir-497 GeneProduct ensembl:ENSG00000284027
CDC25A2 GeneProduct ncbigene:993
hsa-mir-222 GeneProduct ensembl:ENSG00000207725
hsa-mir-421 GeneProduct ensembl:ENSG00000202566
hsa-mir-23b GeneProduct ensembl:ENSG00000207563
CCND1 GeneProduct ncbigene:595
hsa-mir-449a GeneProduct ensembl:ENSG00000198983
TP53 GeneProduct ncbigene:7157
hsa-mir-27a GeneProduct ensembl:ENSG00000207808
hsa-mir-15b GeneProduct ensembl:ENSG00000207779
hsa-mir-17 GeneProduct ensembl:ENSG00000284536
hsa-mir-20a GeneProduct ensembl:ENSG00000283762
hsa-mir-92a-1 GeneProduct ensembl:ENSG00000283705
E2F1 GeneProduct ncbigene:1869
hsa-mir-449b GeneProduct ensembl:ENSG00000207728
RAD52 GeneProduct ncbigene:5893
hsa-mir-330 GeneProduct ensembl:ENSG00000284544

References

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  2. An E2F/miR-20a autoregulatory feedback loop. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, et al. J Biol Chem. 2007 Jan 26;282(4):2135–43. PubMed Europe PMC Scholia
  3. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. Woods K, Thomson JM, Hammond SM. J Biol Chem. 2007 Jan 26;282(4):2130–4. PubMed Europe PMC Scholia
  4. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, et al. Curr Biol. 2007 Aug 7;17(15):1298–307. PubMed Europe PMC Scholia
  5. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. Cancer Res. 2007 Sep 15;67(18):8433–8. PubMed Europe PMC Scholia
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  14. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. Cancer Res. 2009 Feb 1;69(3):1221–9. PubMed Europe PMC Scholia
  15. p53 represses c-Myc through induction of the tumor suppressor miR-145. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3207–12. PubMed Europe PMC Scholia
  16. MiR-34, SIRT1 and p53: the feedback loop. Yamakuchi M, Lowenstein CJ. Cell Cycle. 2009 Mar 1;8(5):712–5. PubMed Europe PMC Scholia
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  19. miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, et al. Nat Struct Mol Biol. 2009 May;16(5):492–8. PubMed Europe PMC Scholia
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  21. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, et al. Oncogene. 2009 Sep 24;28(38):3360–70. PubMed Europe PMC Scholia
  22. microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, et al. Cancer Res. 2009 Oct 15;69(20):8157–65. PubMed Europe PMC Scholia
  23. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, et al. Genes Dev. 2009 Oct 15;23(20):2388–93. PubMed Europe PMC Scholia
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  25. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, et al. Blood. 2010 Mar 4;115(9):1768–78. PubMed Europe PMC Scholia
  26. ATM is down-regulated by N-Myc-regulated microRNA-421. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1506–11. PubMed Europe PMC Scholia
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  29. Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling. Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M. Mol Cell Biol. 2010 Jun;30(12):2983–95. PubMed Europe PMC Scholia
  30. The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Wong P, Iwasaki M, Somervaille TCP, Ficara F, Carico C, Arnold C, et al. Cancer Res. 2010 May 1;70(9):3833–42. PubMed Europe PMC Scholia