Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (WP4284)

Homo sapiens

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The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.

Authors

Kristina Hanspers and Friederike Ehrhart

Activity

last edited

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

microRNA pathway cancer pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact Identifier Comment
TP53 GeneProduct ensembl:ENSG00000141510
CCNE2 GeneProduct ensembl:ENSG00000175305

References

  1. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, et al. Nat Commun. 2017 Nov 27;8(1):1801. PubMed Europe PMC Scholia