Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (WP4284)
The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.
AuthorsKristina Hanspers and Friederike Ehrhart
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OrganismsHomo sapiens CPTAC ExRNA
Pathway OntologymicroRNA pathway cancer pathway