Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (WP4284)

Homo sapiens

The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.

Authors

Kristina Hanspers and Friederike Ehrhart

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited By

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

microRNA pathway cancer pathway

Disease Ontology

cancer

Participants

Label Type Compact Identifier Comment
TP53 GeneProduct ensembl:ENSG00000141510
CCNE2 GeneProduct ensembl:ENSG00000175305

References

  1. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, et al. Nat Commun. 2017 Nov 27;8(1):1801. PubMed Europe PMC Scholia