Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (WP4284)
The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.
AuthorsKristina Hanspers and Friederike Ehrhart
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Pathway OntologymicroRNA pathway cancer pathway
- Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, et al. Nat Commun. 2017 Nov 27;8(1):1801. PubMed Europe PMC Scholia