The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.
a6d
microRNA pathway
PW:0000808
Pathway Ontology
cancer pathway
PW:0000605
Pathway Ontology
cancer
DOID:162
Human Disease Ontology
29180617
PubMed
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.
Nat Commun
2017
Vannini I
Wise PM
Challagundla KB
Plousiou M
Raffini M
Bandini E
Fanini F
Paliaga G
Crawford M
Ferracin M
Ivan C
Fabris L
Davuluri RV
Guo Z
Cortez MA
Zhang X
Chen L
Zhang S
Fernandez-Cymering C
Han L
Carloni S
Salvi S
Ling H
Murtadha M
Neviani P
Gitlitz BJ
Laird-Offringa IA
Nana-Sinkam P
Negrini M
Liang H
Amadori D
Cimmino A
Calin GA
Fabbri M