miRNA regulation of p53 pathway in prostate cancer (WP3982)
Homo sapiens
Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed section to predict potential targets of a subset of highly upregulated miRNAs (>2-fold) in prostate tumors. Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
Authors
Kristina Hanspers , Egon Willighagen , Friederike Ehrhart , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
CPTAC ExRNAAnnotations
Disease Ontology
prostate cancerPathway Ontology
cancer pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| DNA | Metabolite | chebi:16991 | |
| ROS | Metabolite | wikidata:Q424361 | |
| Nitric oxide | Metabolite | chebi:16480 | |
| ATM | GeneProduct | ensembl:ENSG00000149311 | |
| CHEK2 | GeneProduct | ensembl:ENSG00000183765 | |
| MIR4482 | GeneProduct | ensembl:ENSG00000266852 | |
| TP53 | GeneProduct | ensembl:ENSG00000141510 | |
| MIR548C | GeneProduct | ensembl:ENSG00000207546 | |
| MIR1305 | GeneProduct | ensembl:ENSG00000221227 | |
| MIR548B | GeneProduct | ensembl:ENSG00000207982 | |
| MDM2 | GeneProduct | ensembl:ENSG00000135679 | |
| SIAH1 | GeneProduct | ensembl:ENSG00000196470 | |
| PTEN | GeneProduct | ensembl:ENSG00000171862 | |
| P48 | GeneProduct | ensembl:ENSG00000134574 | |
| SESN3 | GeneProduct | ensembl:ENSG00000149212 | |
| SERPINE1 | GeneProduct | ensembl:ENSG00000106366 | |
| Scotin | GeneProduct | ensembl:ENSG00000164054 | |
| EI24 | GeneProduct | ensembl:ENSG00000149547 | |
| BAX | GeneProduct | ensembl:ENSG00000087088 | |
| TNFRSF10B | GeneProduct | ensembl:ENSG00000120889 | |
| PMAIP1 | GeneProduct | ensembl:ENSG00000141682 | |
| BBC3 | GeneProduct | ensembl:ENSG00000105327 | |
| CASP8 | GeneProduct | ensembl:ENSG00000064012 | |
| MIR27B | GeneProduct | ensembl:ENSG00000207864 | |
| PERP | GeneProduct | ensembl:ENSG00000112378 | |
| ZMAT3 | GeneProduct | ensembl:ENSG00000172667 | |
| MIR4491 | GeneProduct | ensembl:ENSG00000264032 | |
| BID | GeneProduct | ensembl:ENSG00000015475 | |
| MIR320A | GeneProduct | ensembl:ENSG00000208037 | |
| MIR182 | GeneProduct | ensembl:ENSG00000207990 | |
| MIR19a | GeneProduct | mirbase.mature:MIMAT0004490 | Annotated with MIMAT because BridegDb not yet up-to-date with latest from Entrez for this entity |
| TP53AIP1 | GeneProduct | ensembl:ENSG00000120471 | |
| CYS1 | GeneProduct | ensembl:ENSG00000205795 | |
| APAF1 | GeneProduct | ensembl:ENSG00000120868 | |
| CASP9 | GeneProduct | ensembl:ENSG00000132906 | |
| CASP3 | GeneProduct | ensembl:ENSG00000164305 |
References
- Identification of microRNA signature and potential pathway targets in prostate cancer. Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, et al. Exp Biol Med (Maywood). 2017 Mar;242(5):536–46. PubMed Europe PMC Scholia