miRNA regulation of p53 pathway in prostate cancer (WP3982)
Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed section to predict potential targets of a subset of highly upregulated miRNAs (>2-fold) in prostate tumors. Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3: http://journals.sagepub.com/doi/suppl/10.1177/1535370216681554. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3982 CPTAC Assay Portal]
AuthorsKristina Hanspers , Egon Willighagen , and Friederike Ehrhart
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Disease Ontologyprostate cancer
Pathway Ontologycancer pathway
- Identification of microRNA signature and potential pathway targets in prostate cancer. Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, et al. Exp Biol Med (Maywood). 2017 Mar;242(5):536–46. PubMed Europe PMC Scholia