miRNA regulation of p53 pathway in prostate cancer (WP3982)

Homo sapiens

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Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed section to predict potential targets of a subset of highly upregulated miRNAs (>2-fold) in prostate tumors. Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3: http://journals.sagepub.com/doi/suppl/10.1177/1535370216681554. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3982 CPTAC Assay Portal]

Authors

Kristina Hanspers , Egon Willighagen , Friederike Ehrhart , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC ExRNA

Annotations

Disease Ontology

prostate cancer

Pathway Ontology

cancer pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
DNA Metabolite chebi:16991
ROS Metabolite wikidata:Q424361
Nitric oxide Metabolite chebi:16480
ATM GeneProduct ensembl:ENSG00000149311
CHEK2 GeneProduct ensembl:ENSG00000183765
MIR4482 GeneProduct ensembl:ENSG00000266852
TP53 GeneProduct ensembl:ENSG00000141510
MIR548C GeneProduct ensembl:ENSG00000207546
MIR1305 GeneProduct ensembl:ENSG00000221227
MIR548B GeneProduct ensembl:ENSG00000207982
MDM2 GeneProduct ensembl:ENSG00000135679
SIAH1 GeneProduct ensembl:ENSG00000196470
PTEN GeneProduct ensembl:ENSG00000171862
P48 GeneProduct ensembl:ENSG00000134574
SESN3 GeneProduct ensembl:ENSG00000149212
SERPINE1 GeneProduct ensembl:ENSG00000106366
Scotin GeneProduct ensembl:ENSG00000164054
EI24 GeneProduct ensembl:ENSG00000149547
BAX GeneProduct ensembl:ENSG00000087088
TNFRSF10B GeneProduct ensembl:ENSG00000120889
MIR548C GeneProduct ensembl:ENSG00000207546
PMAIP1 GeneProduct ensembl:ENSG00000141682
BBC3 GeneProduct ensembl:ENSG00000105327
MIR1305 GeneProduct ensembl:ENSG00000221227
CASP8 GeneProduct ensembl:ENSG00000064012
MIR27B GeneProduct ensembl:ENSG00000207864
PERP GeneProduct ensembl:ENSG00000112378
ZMAT3 GeneProduct ensembl:ENSG00000172667
SIAH1 GeneProduct ensembl:ENSG00000196470
MIR4491 GeneProduct ensembl:ENSG00000264032
MIR548C GeneProduct ensembl:ENSG00000207546
MIR1305 GeneProduct ensembl:ENSG00000221227
BID GeneProduct ensembl:ENSG00000015475
MIR548B GeneProduct ensembl:ENSG00000207982
MIR27B GeneProduct ensembl:ENSG00000207864
MIR320A GeneProduct ensembl:ENSG00000208037
MIR182 GeneProduct ensembl:ENSG00000207990
MIR4482 GeneProduct ensembl:ENSG00000266852
MIR548C GeneProduct ensembl:ENSG00000207546
MIR19a GeneProduct mirbase.mature:MIMAT0004490 Annotated with MIMAT because BridegDb not yet up-to-date with latest from Entrez for this entity
MIR1305 GeneProduct ensembl:ENSG00000221227
MIR27B GeneProduct ensembl:ENSG00000207864
MIR320A GeneProduct ensembl:ENSG00000208037
MIR548C GeneProduct ensembl:ENSG00000207546
MIR1305 GeneProduct ensembl:ENSG00000221227
TP53AIP1 GeneProduct ensembl:ENSG00000120471
CYS1 GeneProduct ensembl:ENSG00000205795
APAF1 GeneProduct ensembl:ENSG00000120868
MIR548C GeneProduct ensembl:ENSG00000207546
CASP9 GeneProduct ensembl:ENSG00000132906
CASP3 GeneProduct ensembl:ENSG00000164305

References

  1. Identification of microRNA signature and potential pathway targets in prostate cancer. Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, et al. Exp Biol Med (Maywood). 2017 Mar;242(5):536–46. PubMed Europe PMC Scholia