MicroRNA network associated with chronic lymphocytic leukemia (WP4399)

Homo sapiens

MicroRNA network associated with Chronic lymphocytic leukemia (CLL). The pink interactions represent effects of deletions/mutations. The mir15/16-p53 feedback circuit was originally described in Fabbri et al.


Kristina Hanspers


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Homo sapiens




Cell Type Ontology

B cell

Disease Ontology

chronic lymphocytic leukemia

Pathway Ontology

altered p53 signaling pathway


Label Type Compact URI Comment
ZAP70 GeneProduct ensembl:ENSG00000115085
BCL2 GeneProduct ensembl:ENSG00000171791
TP53 GeneProduct ensembl:ENSG00000141510
MIR15A GeneProduct ensembl:ENSG00000283785
MIR16-1 GeneProduct ensembl:ENSG00000208006
MCL1 GeneProduct ensembl:ENSG00000143384


  1. The 13q and 11q B-cell chronic lymphocytic leukaemia-associated regions derive from a common ancestral region in the zebrafish. Auer RL, Riaz S, Cotter FE. Br J Haematol. 2007 Jun;137(5):443–53. PubMed Europe PMC Scholia
  2. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, et al. JAMA. 2011 Jan 5;305(1):59–67. PubMed Europe PMC Scholia
  3. MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights. Ciccone M, Calin GA. Microrna. 2016;5(2):106–12. PubMed Europe PMC Scholia