lncRNA in canonical Wnt signaling and colorectal cancer (WP4258)

Homo sapiens

Long non-coding RNAs (lncRNAs) have emerged as significant players in colorectal cancer pathogenesis. This pathway represents a review of long non-coding RNA (LncRNA) involvement in canonical Wnt signaling as it relates to colorectal cancer. The pathway is adapted from [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618652/ Shen et al] . Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.


Kristina Hanspers , Friederike Ehrhart , Eric Weitz , and Egon Willighagen


last edited

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Homo sapiens




Pathway Ontology

colorectal cancer pathway disease pathway Wnt signaling, canonical pathway Wnt signaling, canonical pathway Wnt signaling pathway cancer pathway

Disease Ontology

colorectal cancer


Label Type Compact URI Comment
APC2 GeneProduct ensembl:ENSG00000115266
DVL3 GeneProduct ncbigene:1857
PLAU GeneProduct ncbigene:5328
RUVBL1 GeneProduct ensembl:ENSG00000175792
FRAT1 GeneProduct ncbigene:10023
GSK3B GeneProduct ncbigene:2932 MOUSE:KG38 MOUSE
CSNK2B GeneProduct ensembl:ENSG00000204435
APC GeneProduct ncbigene:324
WNT3A GeneProduct ncbigene:89780
FZD3 GeneProduct ncbigene:7976
LEF1 GeneProduct ensembl:ENSG00000138795
HNRNPK GeneProduct ensembl:ENSG00000165119
CSNK1E GeneProduct ncbigene:1454
CCND1 GeneProduct ncbigene:595
FZD8 GeneProduct ncbigene:8325
TCF7L1 GeneProduct ensembl:ENSG00000152284
WNT7A GeneProduct ncbigene:7476
CDK6 GeneProduct ensembl:ENSG00000105810
TCF7L2 GeneProduct ensembl:ENSG00000148737
WNT11 GeneProduct ncbigene:7481
WNT1 GeneProduct ncbigene:7471
JUN GeneProduct ncbigene:3725
LRP5 GeneProduct ncbigene:4041
FZD10 GeneProduct ncbigene:11211
FZD7 GeneProduct ncbigene:8324
MIR34A GeneProduct ensembl:ENSG00000228526
WNT5B GeneProduct ncbigene:81029
CTNNB1 GeneProduct ncbigene:1499
WNT2 GeneProduct ncbigene:7472
TCF3 GeneProduct ensembl:ENSG00000071564
CSNK1A1 GeneProduct ensembl:ENSG00000113712
WNT2B GeneProduct ncbigene:7482
FZD4 GeneProduct ncbigene:6424
DVL2 GeneProduct ncbigene:1856
WNT6 GeneProduct ncbigene:7475
CCND3 GeneProduct ncbigene:896
EZH2 GeneProduct ensembl:ENSG00000106462
WNT5A GeneProduct ncbigene:7474
ROR1 GeneProduct ncbigene:4919
FZD1 GeneProduct ncbigene:8321
LRP6 GeneProduct ncbigene:4040
KREM1 GeneProduct ncbigene:83999
WNT16 GeneProduct ncbigene:51384
FZD6 GeneProduct ncbigene:8323
RYK GeneProduct ncbigene:6259
WNT4 GeneProduct ncbigene:54361
WNT3 GeneProduct ncbigene:7473
CSNK2A1 GeneProduct ensembl:ENSG00000101266
AXIN1 GeneProduct ncbigene:8312
WNT10B GeneProduct ncbigene:7480
MAP3K7 GeneProduct ensembl:ENSG00000135341
FZD5 GeneProduct ncbigene:7855
WNT7B GeneProduct ncbigene:7477
DVL1 GeneProduct ncbigene:1855
CHD8 GeneProduct ensembl:ENSG00000100888
WNT10A GeneProduct ncbigene:80326
CDK8 GeneProduct ensembl:ENSG00000132964
CSNK1A1L GeneProduct ensembl:ENSG00000180138
CSNK2A3 GeneProduct ensembl:ENSG00000254598
FOSL1 GeneProduct ncbigene:8061
H2AFY2 GeneProduct ensembl:ENSG00000099284
MYC GeneProduct ncbigene:4609
CSNK2A2 GeneProduct ensembl:ENSG00000070770
CCND2 GeneProduct ncbigene:894
TFAP2A GeneProduct ensembl:ENSG00000137203
FZD9 GeneProduct ncbigene:8326
ATF3 GeneProduct ensembl:ENSG00000162772
TCF7 GeneProduct ensembl:ENSG00000081059
WNT16 GeneProduct ncbigene:51384
FZD2 GeneProduct ncbigene:2535
ROR2 GeneProduct ncbigene:4920
CTNNB1 GeneProduct ncbigene:1499
DKK1 GeneProduct ensembl:ENSG00000107984
DKK2 GeneProduct ensembl:ENSG00000155011
DKK4 GeneProduct ensembl:ENSG00000104371
SOST GeneProduct ensembl:ENSG00000167941
SERPINF1 GeneProduct ensembl:ENSG00000132386
FRAT2 GeneProduct ensembl:ENSG00000181274
CTNNB1 GeneProduct ncbigene:1499
SFRP1 GeneProduct ensembl:ENSG00000104332
SFRP2 GeneProduct ensembl:ENSG00000145423
SFRP4 GeneProduct ensembl:ENSG00000106483
SFRP5 GeneProduct ensembl:ENSG00000120057
NOTUM GeneProduct ensembl:ENSG00000185269
CER1 GeneProduct ensembl:ENSG00000147869
WIF1 GeneProduct ensembl:ENSG00000156076
PORCN GeneProduct ensembl:ENSG00000102312
NKD1 GeneProduct ensembl:ENSG00000140807
NKD2 GeneProduct ensembl:ENSG00000145506
CXXC4 GeneProduct ensembl:ENSG00000168772
SENP2 GeneProduct ensembl:ENSG00000163904
NLK GeneProduct ensembl:ENSG00000087095
CTNNBIP1 GeneProduct ensembl:ENSG00000178585
SOX17 GeneProduct ensembl:ENSG00000164736
CTBP1 GeneProduct ensembl:ENSG00000159692
CTBP2 GeneProduct ensembl:ENSG00000175029
MIR16-2 GeneProduct ensembl:ENSG00000198987
MIR16-1 GeneProduct ensembl:ENSG00000208006
H19 GeneProduct ensembl:ENSG00000130600
NKD1 GeneProduct ensembl:ENSG00000140807
HNRNPU GeneProduct ensembl:ENSG00000153187
H19 GeneProduct ensembl:ENSG00000130600
H19 GeneProduct ensembl:ENSG00000130600
AXIN2 GeneProduct ensembl:ENSG00000168646


  1. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia
  2. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer. Shen P, Pichler M, Chen M, Calin GA, Ling H. Int J Mol Sci. 2017 Sep 20;18(9):2003. PubMed Europe PMC Scholia