FABP4 in ovarian cancer (WP4400)

Homo sapiens

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Regulation of FABP4 in ovarian cancer. FABP4 (fatty acid binding protein) can substantially increase metastatic potential of ovarian cancer cells, and leads to more aggressive disease. Mir-409-3p negatively regulates FABP4 in ovarian cancer cells, and mir-409-3p is decreased in hypoxic conditions. Pink arrows indicates potential therapuetic therapeutic stratgeies; in Gharpure et al, DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA was shown to inhibit tumor progression. Description was adapted from Gharpure et al.

Authors

Kristina Hanspers , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

microRNA pathway cancer pathway

Disease Ontology

ovarian cancer

Cell Type Ontology

neoplastic cell

Participants
Query Drugst.One

Label Type Compact URI Comment
FABP4 GeneProduct ensembl:ENSG00000170323

References

  1. FABP4 as a key determinant of metastatic potential of ovarian cancer. Gharpure KM, Pradeep S, Sans M, Rupaimoole R, Ivan C, Wu SY, et al. Nat Commun. 2018 Jul 26;9(1):2923. PubMed Europe PMC Scholia