FABP4 in ovarian cancer (WP4400)

Homo sapiens

Regulation of FABP4 in ovarian cancer. FABP4 (fatty acid binding protein) can substantially increase metastatic potential of ovarian cancer cells, and leads to more aggressive disease. Mir-409-3p negatively regulates FABP4 in ovarian cancer cells, and mir-409-3p is decreased in hypoxic conditions. Pink arrows indicates potential therapuetic therapeutic stratgeies; in Gharpure et al, DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA was shown to inhibit tumor progression. Description was adapted from Gharpure et al.


Kristina Hanspers and Friederike Ehrhart


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Homo sapiens



Disease Ontology

ovarian cancer

Pathway Ontology

microRNA pathway cancer pathway


Label Type Compact Identifier Comment
FABP4 GeneProduct ensembl:ENSG00000170323


  1. FABP4 as a key determinant of metastatic potential of ovarian cancer. Gharpure KM, Pradeep S, Sans M, Rupaimoole R, Ivan C, Wu SY, et al. Nat Commun. 2018 Jul 26;9(1):2923. PubMed Europe PMC Scholia