FABP4 in ovarian cancer (WP4400)
Regulation of FABP4 in ovarian cancer. FABP4 (fatty acid binding protein) can substantially increase metastatic potential of ovarian cancer cells, and leads to more aggressive disease. Mir-409-3p negatively regulates FABP4 in ovarian cancer cells, and mir-409-3p is decreased in hypoxic conditions. Pink arrows indicates potential therapuetic therapeutic stratgeies; in Gharpure et al, DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA was shown to inhibit tumor progression. Description was adapted from Gharpure et al.
AuthorsKristina Hanspers and Friederike Ehrhart
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OrganismsHomo sapiens ExRNA
Disease Ontologyovarian cancer
Pathway OntologymicroRNA pathway cancer pathway