SREBF and miR33 in cholesterol and lipid homeostasis (WP2011)

Homo sapiens

This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Samuel Sklar , Kristina Hanspers , Linda Rieswijk , Martina Summer-Kutmon , Finterly Hu , and Eric Weitz


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Homo sapiens




Pathway Ontology

cholesterol metabolic pathway transcription pathway homeostasis pathway


Label Type Compact URI Comment
SREBF1 GeneProduct ensembl:ENSG00000072310
PPARGC1A GeneProduct ensembl:ENSG00000109819
FASN GeneProduct ncbigene:2194
SIRT6 GeneProduct ensembl:ENSG00000077463
HMGCR GeneProduct ensembl:ENSG00000113161
SIRT1 GeneProduct ensembl:ENSG00000096717
MTOR GeneProduct ensembl:ENSG00000198793
SCD GeneProduct ncbigene:6319
NR1H3 GeneProduct ensembl:ENSG00000025434
PPARA GeneProduct ensembl:ENSG00000186951
MED15 GeneProduct ensembl:ENSG00000099917
SREBF2 GeneProduct ensembl:ENSG00000198911
HMGCS1 GeneProduct ensembl:ENSG00000112972
LDLR GeneProduct ensembl:ENSG00000130164
ABCA1 GeneProduct ncbigene:19
PRKAA1 GeneProduct ncbigene:5562


  1. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, et al. Nature. 2006 Aug 10;442(7103):700–4. PubMed Europe PMC Scholia
  2. Receptor feasts on sugar and cholesterol. Rodgers JT, Puigserver P. Nat Med. 2007 Feb;13(2):128–9. PubMed Europe PMC Scholia
  3. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, et al. EMBO J. 2007 Apr 4;26(7):1913–23. PubMed Europe PMC Scholia
  4. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, et al. EMBO J. 2007 Jul 11;26(13):3169–79. PubMed Europe PMC Scholia
  5. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Rodgers JT, Puigserver P. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861–6. PubMed Europe PMC Scholia
  6. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. Nature. 2007 Nov 29;450(7170):736–40. PubMed Europe PMC Scholia
  7. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, et al. Genes Dev. 2010 Jul 1;24(13):1403–17. PubMed Europe PMC Scholia
  8. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, et al. J Biol Chem. 2010 Oct 29;285(44):33652–61. PubMed Europe PMC Scholia
  9. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17321–6. PubMed Europe PMC Scholia