miR-517 relationship with ARCN1 and USP1 (WP3596)

Homo sapiens

Open in new tab Open in NDEx
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3596 CPTAC Assay Portal].

Authors

Kristina Hanspers , Ryan Miller , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
USP1 GeneProduct ensembl:ENSG00000162607
ARCN1 GeneProduct ensembl:ENSG00000095139
p21 GeneProduct ensembl:ENSG00000124762
ID1 GeneProduct ensembl:ENSG00000125968
ID2 GeneProduct ensembl:ENSG00000115738

References

  1. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, et al. Mol Syst Biol. 2015 Dec 11;11(12):842. PubMed Europe PMC Scholia