Extracellular vesicle-mediated signaling in recipient cells (WP2870)

Homo sapiens

Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2870 CPTAC Assay Portal]


Kristina Hanspers , Alex Pico , Zahra Roudbari , and Susan Coort


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens




Disease Ontology

cancer nervous system disease

Pathway Ontology

signaling pathway


Label Type Compact URI Comment
SMAD4 GeneProduct ncbigene:4089
SMAD2 GeneProduct ncbigene:4087
SMAD3 GeneProduct ncbigene:4088
WNT3A GeneProduct ncbigene:89780
WNT5A GeneProduct ncbigene:7474
ERBB2 GeneProduct ncbigene:2064
EGFR GeneProduct ncbigene:1956
MFGE8 GeneProduct ncbigene:4240
TSPAN8 GeneProduct ncbigene:7103
DKK4 GeneProduct ncbigene:27121
TGFA GeneProduct ncbigene:7039
TGFB1 GeneProduct ncbigene:7040
CD133 GeneProduct ncbigene:8842
AKT1 GeneProduct ncbigene:207
MTOR GeneProduct ncbigene:2475
HGF GeneProduct ncbigene:3082
HGFR GeneProduct ncbigene:4233
PI3K GeneProduct ncbigene:23533
HRAS GeneProduct ncbigene:3265
KRAS GeneProduct ncbigene:3845
RAF1 GeneProduct ncbigene:5894
TGFBR1 GeneProduct ncbigene:7046
TGFBR3 GeneProduct ncbigene:7049
TGFB1 GeneProduct ncbigene:7040
TGFB2 GeneProduct ncbigene:7042
TGFB3 GeneProduct ncbigene:7043
APC GeneProduct ncbigene:324
AXIN1 GeneProduct ncbigene:8312
CTNNB1 GeneProduct ncbigene:1499
AKT1 GeneProduct ncbigene:207
NRAS Protein ncbigene:4893
TGFBR2 Protein ncbigene:7048


  1. Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic? Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S. Proteomics. 2015 Jan;15(2–3):260–71. PubMed Europe PMC Scholia