Extracellular vesicle-mediated signaling in recipient cells (WP2870)

Homo sapiens

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Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2870 CPTAC Assay Portal]

Authors

Kristina Hanspers , Alex Pico , Zahra Roudbari , Susan Coort , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Disease Ontology

cancer nervous system disease

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
RAF1 GeneProduct ncbigene:5894
HGFR GeneProduct ncbigene:4233
TGFA GeneProduct ncbigene:7039
SMAD3 GeneProduct ncbigene:4088
APC GeneProduct ncbigene:324
MFGE8 GeneProduct ncbigene:4240
CTNNB1 GeneProduct ncbigene:1499
TGFBR3 GeneProduct ncbigene:7049
WNT5A GeneProduct ncbigene:7474
TGFBR1 GeneProduct ncbigene:7046
KRAS GeneProduct ncbigene:3845
TGFB2 GeneProduct ncbigene:7042
MTOR GeneProduct ncbigene:2475
ERBB2 GeneProduct ncbigene:2064
TSPAN8 GeneProduct ncbigene:7103
SMAD2 GeneProduct ncbigene:4087
TGFB1 GeneProduct ncbigene:7040
RTK GeneProduct wikipathways:WP5471
SMAD4 GeneProduct ncbigene:4089
HRAS GeneProduct ncbigene:3265
AXIN1 GeneProduct ncbigene:8312
TGFB3 GeneProduct ncbigene:7043
CD133 GeneProduct ncbigene:8842
TGFB1 GeneProduct ncbigene:7040
EGFR GeneProduct ncbigene:1956
HGF GeneProduct ncbigene:3082
DKK4 GeneProduct ncbigene:27121
WNT3A GeneProduct ncbigene:89780
AKT1 GeneProduct ncbigene:207
AKT1 GeneProduct ncbigene:207
PI3K GeneProduct wikipathways:WP5472
NRAS Protein ncbigene:4893
TGFBR2 Protein ncbigene:7048

References

  1. Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic? Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S. Proteomics. 2015 Jan;15(2–3):260–71. PubMed Europe PMC Scholia