Fatty acid transporters (WP5061)

Homo sapiens

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This transport pathway shows several tissue specific fatty acid transport proteins (FATP), which facilitate fatty acid uptake. The extracellular fatty acids can either bind to CD36 or bind directly to the fatty acid transporters. When the fatty acids have entered the cell, they can either be coupled to Acyl-CoA by long-chain fatty acyl-CoA synthetases or bind to fatty acid binding proteins (FABPs). This binding of the fatty acids to CoA or FABPs prevents the efflux of the fatty acids.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Jeroen Kearns , Egon Willighagen , Eric Weitz , and Daniela Digles

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

ONTOX

Annotations

Cell Type Ontology

cardiocyte kidney cell fat cell hepatocyte

Pathway Ontology

transport pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
COENZYME A Metabolite chebi:15346
LCFAs Metabolite chebi:15904
ACSBG1 GeneProduct ensembl:ENSG00000103740
SLC27A6 GeneProduct hgnc.symbol:HGNC:11000
ACSL1 GeneProduct ensembl:ENSG00000151726
CD36 GeneProduct ensembl:ENSG00000135218
SLC27A2 GeneProduct hgnc.symbol:HGNC:10996
ACSL6 GeneProduct ensembl:ENSG00000164398
FABP4 GeneProduct ensembl:ENSG00000170323
FABP1 GeneProduct ensembl:ENSG00000163586
FABP5 GeneProduct ensembl:ENSG00000164687
ACSL4 GeneProduct ensembl:ENSG00000068366
FABP3 GeneProduct ensembl:ENSG00000121769
ACSL3 GeneProduct ensembl:ENSG00000123983
SLC27A4 GeneProduct hgnc.symbol:SLC27A4
FABP7 GeneProduct ensembl:ENSG00000164434
DBI GeneProduct ensembl:ENSG00000155368
FABP9 GeneProduct ensembl:ENSG00000205186
FABP2 GeneProduct ensembl:ENSG00000145384
SLC27A5 GeneProduct hgnc.symbol:HGNC:10999
FABP1 GeneProduct hgnc.symbol:HGNC:3555
SLC27A3 GeneProduct hgnc.symbol:HGNC:10997
SLC27A1 GeneProduct hgnc.symbol:HGNC:10995
ACSL5 GeneProduct ensembl:ENSG00000197142
SLC27A4 GeneProduct ensembl:ENSG00000167114
ACSBG2 GeneProduct ensembl:ENSG00000130377
FABP6 GeneProduct ensembl:ENSG00000170231

References

  1. Expression of fatty-acid-binding proteins in cells involved in lung-specific lipid metabolism. Guthmann F, Hohoff C, Fechner H, Humbert P, Börchers T, Spener F, et al. Eur J Biochem. 1998 Apr 15;253(2):430–6. PubMed Europe PMC Scholia
  2. Insights into binding of fatty acids by fatty acid binding proteins. Hanhoff T, Lücke C, Spener F. Mol Cell Biochem. 2002 Oct;239(1–2):45–54. PubMed Europe PMC Scholia
  3. A current review of fatty acid transport proteins (SLC27). Stahl A. Pflugers Arch. 2004 Feb;447(5):722–7. PubMed Europe PMC Scholia
  4. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. Chmurzyńska A. J Appl Genet. 2006;47(1):39–48. PubMed Europe PMC Scholia
  5. Long-chain acyl-CoA synthetases and fatty acid channeling. Mashek DG, Li LO, Coleman RA. Future Lipidol. 2007 Aug;2(4):465–76. PubMed Europe PMC Scholia
  6. The human fatty acid-binding protein family: evolutionary divergences and functions. Smathers RL, Petersen DR. Hum Genomics. 2011 Mar;5(3):170–91. PubMed Europe PMC Scholia
  7. Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, et al. Cell Rep. 2016 Aug 9;16(6):1614–28. PubMed Europe PMC Scholia