Programmed cell death (WP367)

Caenorhabditis elegans

Programmed Cell Death pathway. Based on conference notes, european worm meeting 2004


Martijn Van Iersel , Brent Derry , Kristina Hanspers , Daniela Digles , and Eric Weitz


last edited

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Caenorhabditis elegans



Pathway Ontology

apoptotic cell death pathway


Label Type Compact URI Comment
ced-3 GeneProduct wormbase:C48D1.2
ced-4 GeneProduct wormbase:C35D10.9
cep-1 GeneProduct wormbase:F52B5.5
egl-1 GeneProduct wormbase:F23B12.9
ced-13 GeneProduct wormbase:R09F10.9
gld-3 GeneProduct wormbase:T07F8.3
gld-1 GeneProduct wormbase:T23G11.3
hus-1 GeneProduct wormbase:H26D21.1
clk-2 GeneProduct wormbase:C07H6.6
mrt-2 GeneProduct wormbase:Y41C4A.14
ced-9 GeneProduct wormbase:T07C4.8
akt-1 GeneProduct wormbase:C12D8.10
hpr-9 GeneProduct wormbase:Y39A1A.23
abl-1 GeneProduct wormbase:M79.1
fsn-1 GeneProduct wormbase:C26E6.5
ape-1 GeneProduct wormbase:F46F3.4
pax-2 GeneProduct wormbase:K06B9.5
egl-38 GeneProduct wormbase:C04G2.7


  1. A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans. Gartner A, Milstein S, Ahmed S, Hodgkin J, Hengartner MO. Mol Cell. 2000 Mar;5(3):435–43. PubMed Europe PMC Scholia
  2. Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Derry WB, Putzke AP, Rothman JH. Science. 2001 Oct 19;294(5542):591–5. PubMed Europe PMC Scholia
  3. The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Schumacher B, Hofmann K, Boulton S, Gartner A. Curr Biol. 2001 Oct 30;11(21):1722–7. PubMed Europe PMC Scholia
  4. C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Ahmed S, Alpi A, Hengartner MO, Gartner A. Curr Biol. 2001 Dec 11;11(24):1934–44. PubMed Europe PMC Scholia
  5. Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Hofmann ER, Milstein S, Boulton SJ, Ye M, Hofmann JJ, Stergiou L, et al. Curr Biol. 2002 Nov 19;12(22):1908–18. PubMed Europe PMC Scholia
  6. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Bergamaschi D, Samuels Y, O’Neil NJ, Trigiante G, Crook T, Hsieh JK, et al. Nat Genet. 2003 Feb;33(2):162–7. PubMed Europe PMC Scholia
  7. Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, et al. Nat Genet. 2004 Aug;36(8):906–12. PubMed Europe PMC Scholia
  8. C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, et al. Cell Death Differ. 2005 Feb;12(2):153–61. PubMed Europe PMC Scholia
  9. Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Schumacher B, Hanazawa M, Lee MH, Nayak S, Volkmann K, Hofmann ER, et al. Cell. 2005 Feb 11;120(3):357–68. PubMed Europe PMC Scholia
  10. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, Kaplan DR, Derry WB. Curr Biol. 2007 Feb 6;17(3):286–92. PubMed Europe PMC Scholia
  11. The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans. Gao MX, Liao EH, Yu B, Wang Y, Zhen M, Derry WB. Cell Death Differ. 2008 Jun;15(6):1054–62. PubMed Europe PMC Scholia
  12. Germline survival and apoptosis. Gartner A, Boag PR, Blackwell TK. WormBook. 2008 Sep 4;1–20. PubMed Europe PMC Scholia