Type II interferon signaling (WP619)

Homo sapiens

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP619 CPTAC Assay Portal]

Authors

Thomas Kelder , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology

Jak-Stat signaling pathway type II interferon signaling pathway

Participants

Label Type Compact URI Comment
IFNG GeneProduct ncbigene:3458
IFNG GeneProduct ncbigene:3458
IFNG GeneProduct ncbigene:3458
IFNGR1 GeneProduct ncbigene:3459
IFNGR2 GeneProduct ncbigene:3460
JAK1 GeneProduct ncbigene:3716
JAK2 GeneProduct ncbigene:3717
JAK2 GeneProduct ncbigene:3717
IFNGR2 GeneProduct ncbigene:3460
IFNGR1 GeneProduct ncbigene:3459
JAK1 GeneProduct ncbigene:3716
IFNG GeneProduct ncbigene:3458
JAK2 GeneProduct ncbigene:3717
IFNGR2 GeneProduct ncbigene:3460
IFNGR1 GeneProduct ncbigene:3459
JAK1 GeneProduct ncbigene:3716
IFNGR2 GeneProduct ncbigene:3460
IFNG GeneProduct ncbigene:3458
JAK1 GeneProduct ncbigene:3716
JAK2 GeneProduct ncbigene:3717
IFNGR1 GeneProduct ncbigene:3459
SOCS3 GeneProduct ncbigene:9021
SOCS1 GeneProduct ncbigene:8651
PTPN11 GeneProduct ncbigene:5781
STAT1 GeneProduct ncbigene:6772
STAT1 [P] GeneProduct ncbigene:6772
STAT2 [P] GeneProduct ncbigene:6773
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
IRF9 GeneProduct ncbigene:10379
(ISGF3) GeneProduct ncbigene:10379
IRF9 GeneProduct ncbigene:10379
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
IRF9 GeneProduct ncbigene:10379
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
PRKCD GeneProduct ncbigene:5580
PTP GeneProduct ncbigene:5967
IRF4 GeneProduct ncbigene:3662
SPI1 GeneProduct ncbigene:6688
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
IRF9 GeneProduct ncbigene:10379
(ISGF3) GeneProduct ncbigene:10379
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
IRF9 GeneProduct ncbigene:10379
IFNA GeneProduct ncbigene:3440
IFNB1 GeneProduct ncbigene:3456
HLA-B GeneProduct ncbigene:3106
NOS2A GeneProduct ncbigene:4843
GBP1 GeneProduct ncbigene:2633
HIST2H4 GeneProduct ncbigene:8370
PSMB9 GeneProduct ncbigene:5698
TAP1 GeneProduct ncbigene:6890
OAS1 GeneProduct ncbigene:4938
CXCL10 GeneProduct ncbigene:3627
CIITA GeneProduct ncbigene:4261
CYBB GeneProduct ncbigene:1536
IL1B GeneProduct ncbigene:3553
IFIT2 GeneProduct ncbigene:3433
EIF2AK2 GeneProduct ncbigene:5610
G1P3 GeneProduct ncbigene:2537
IRF1 GeneProduct ncbigene:3659
ICAM1 GeneProduct ncbigene:3383
CXCL9 GeneProduct ncbigene:4283
G1P2 GeneProduct ncbigene:9636
IRF8 [P] GeneProduct ncbigene:3394
IRF8 GeneProduct ncbigene:3394
IRF2 GeneProduct ncbigene:3660

References

  1. A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia