Wnt signaling pathway and pluripotency (WP723)

Mus musculus

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.


Nathan Salomonis , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Lli9 , Alex Pico , Denise Slenter , and Eric Weitz


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Mus musculus



Pathway Ontology

Wnt signaling, canonical pathway


Label Type Compact URI Comment
Trp53 GeneProduct ncbigene:22059
Ppp2r2a GeneProduct ncbigene:71978
Prkcq GeneProduct ncbigene:18761
Dvl2 GeneProduct ncbigene:13543
Ppp2r1b GeneProduct ncbigene:73699
Fzd1 GeneProduct ncbigene:14362
Wnt5a GeneProduct ncbigene:22418
Lrp6 GeneProduct ncbigene:16974
Ppp2r2c GeneProduct ncbigene:269643
Prkcb GeneProduct ncbigene:18751
Wnt11 GeneProduct ncbigene:22411
Fzd7 GeneProduct ncbigene:14369
Ctbp2 GeneProduct ncbigene:13017
Ppp2cb GeneProduct ncbigene:19053
Ppp2ca GeneProduct ncbigene:19052
Crebbp GeneProduct ncbigene:12914
Dvl1 GeneProduct ncbigene:13542
Fzd4 GeneProduct ncbigene:14366
Tcf3 GeneProduct ncbigene:21415
Wnt16 GeneProduct ncbigene:93735
Fosl1 GeneProduct ncbigene:14283
Ppp2r2d GeneProduct ncbigene:52432
Fzd8 GeneProduct ncbigene:14370
Tcf4 GeneProduct ncbigene:21413
Map3k7 GeneProduct ncbigene:26409
Gsk3b GeneProduct ncbigene:56637
Frat1 GeneProduct ensembl:ENSMUSG00000067199
Ctbp1 GeneProduct ncbigene:13016
Wnt10b GeneProduct ncbigene:22410
Ppm1j GeneProduct ncbigene:71887
Myc GeneProduct ncbigene:17869
Ldlr GeneProduct ncbigene:16835
Wnt5b GeneProduct ncbigene:22419
Ctnnb1 GeneProduct ncbigene:12387
Wnt1 GeneProduct ncbigene:22408
Wnt11 GeneProduct ncbigene:22411 Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
Wnt7b GeneProduct ncbigene:22422
Wnt3a GeneProduct ncbigene:22416
Ccnd2 GeneProduct ncbigene:12444
Dvl3 GeneProduct ncbigene:13544
Mmp7 GeneProduct ncbigene:17393
Mapk9 GeneProduct ncbigene:26420
Wnt7a GeneProduct ncbigene:22421
Nfya GeneProduct ncbigene:18044
Prkca GeneProduct ncbigene:18750
Wnt2b GeneProduct ncbigene:22414
Lef1 GeneProduct ncbigene:16842
Ppp2r5c GeneProduct ncbigene:26931
Nkd2 GeneProduct ncbigene:72293
Tcf2 GeneProduct ncbigene:21410
Fzd3 GeneProduct ncbigene:14365
Sox2 GeneProduct ncbigene:20674
Plau GeneProduct ncbigene:18792
Prkch GeneProduct ncbigene:18755
Prkd1 GeneProduct ncbigene:18760
Wnt2 GeneProduct ncbigene:22413
Fbxw2 GeneProduct ncbigene:30050
Pafah1b1 GeneProduct ncbigene:18472
Ppard GeneProduct ncbigene:19015
Nlk GeneProduct ncbigene:18099
Ppp2r1a GeneProduct ncbigene:51792
Tcf1 GeneProduct ncbigene:21405
Prkcc GeneProduct ncbigene:18752
Prkcz GeneProduct ncbigene:18762
Fzd6 GeneProduct ncbigene:14368
Fzd2 GeneProduct ncbigene:57265
Ppp2r2b GeneProduct ncbigene:72930
Axin2 GeneProduct ncbigene:12006
Ccnd3 GeneProduct ncbigene:12445
Fzd5 GeneProduct ncbigene:14367
Wnt4 GeneProduct ncbigene:22417
Nanog GeneProduct ncbigene:71950
Apc GeneProduct ncbigene:11789
Ppp2r5e GeneProduct ncbigene:26932
Jun GeneProduct ncbigene:16476
Ep300 GeneProduct ncbigene:328572
Wnt9b GeneProduct ncbigene:22412
Lrp5 GeneProduct ncbigene:16973
Ctnnd1 GeneProduct ncbigene:12388
Wnt6 GeneProduct ncbigene:22420
Mapk10 GeneProduct ncbigene:26414
Prkcd GeneProduct ncbigene:18753
Ppp2r4 GeneProduct ncbigene:110854
Pou5f1 GeneProduct ncbigene:18999
Ccnd1 GeneProduct ncbigene:12443
Axin1 GeneProduct ncbigene:12005
Racgap1 GeneProduct ncbigene:26934
Wnt10a GeneProduct ncbigene:22409
Csnk1e GeneProduct ncbigene:27373
Wnt3 GeneProduct ncbigene:22415
Zbtb33 GeneProduct ncbigene:56805
Nkd1 GeneProduct ncbigene:93960
Prkce GeneProduct ncbigene:18754
Fzd9 GeneProduct ncbigene:14371
Prkci GeneProduct ncbigene:18759
Foxd3 GeneProduct ncbigene:15221
Rhoa GeneProduct ncbigene:11848
Cd44 GeneProduct ncbigene:12505


  1. Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Sato N, Brivanlou AH. Methods Mol Biol. 2006;331:115–28. PubMed Europe PMC Scholia
  2. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia