Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway) (WP5148)

Homo sapiens

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Hypothetical pathway for complement-mediated inflammation of the pulmonary alveolus in COVID-19. AEC‐II=Type II alveolar epithelial cell, EC=endothelial cells and MC=monocytes.

Authors

Susan Coort , Eric Weitz , Egon Willighagen , Nhung Pham , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

COVID-19

Pathway Ontology

lectin complement pathway

Cell Type Ontology

epithelial cell of alveolus of lung

Participants
Query Drugst.One

Label Type Compact URI Comment
C6 GeneProduct ensembl:ENSG00000039537
C5b GeneProduct ensembl:ENSG00000106804
ACE2 GeneProduct ensembl:ENSG00000130234
MASP2 GeneProduct ensembl:ENSG00000009724
C7 GeneProduct ensembl:ENSG00000112936
C8 GeneProduct ncbigene:731
C3 GeneProduct ensembl:ENSG00000125730
C3AR1 GeneProduct ensembl:ENSG00000171860
C5 GeneProduct ensembl:ENSG00000106804
C5AR1 GeneProduct ensembl:ENSG00000197405
C9 GeneProduct ensembl:ENSG00000113600
ACE2 GeneProduct ensembl:ENSG00000130234
MASP2 GeneProduct ensembl:ENSG00000009724
C3AR1 GeneProduct ensembl:ENSG00000171860
C5AR1 GeneProduct ensembl:ENSG00000197405
C3 GeneProduct ensembl:ENSG00000125730
C5 GeneProduct ensembl:ENSG00000106804
C6 GeneProduct ensembl:ENSG00000039537
C5b GeneProduct ensembl:ENSG00000106804
C7 GeneProduct ensembl:ENSG00000112936
C8 GeneProduct ncbigene:731
C9 GeneProduct ensembl:ENSG00000113600
C5AR1 GeneProduct ensembl:ENSG00000197405
C5AR1 GeneProduct ensembl:ENSG00000197405
C3AR1 GeneProduct ensembl:ENSG00000171860
C5AR1 GeneProduct ensembl:ENSG00000197405
Collectin-11 Protein uniprot:F8WB29
Ficolin-1 Protein uniprot:O00602
Collectin-11 Protein uniprot:F8WB29
Ficolin-1 Protein uniprot:O00602

References

  1. Rationale for targeting complement in COVID-19. Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G, Wallis R, et al. EMBO Mol Med. 2020 Aug 7;12(8):e12642. PubMed Europe PMC Scholia