Prostaglandin synthesis and regulation (WP995)

Bos taurus

A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. They are mediators and have a variety of strong physiological effects, such as regulating the contraction and relaxation of smooth muscle tissue.[1] Prostaglandins are not hormones, but autocrine or paracrine, which are locally acting messenger molecules. They differ from hormones in that they are not produced at a discrete site but in many places throughout the human body. Also, their target cells are present in the immediate vicinity of the site of their secretion (of which there are many). The prostaglandins, together with the thromboxanes and prostacyclins, form the prostanoid class of fatty acid derivatives, a subclass of eicosanoids. Source: Wikipedia ([[wikipedia:Prostaglandin]])

Authors

Martina Summer-Kutmon , Egon Willighagen , Denise Slenter , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

prostaglandin metabolic pathway

Participants

Label Type Compact URI Comment
Prostaglandin H2 Metabolite cas:745-65-3
Calcium Metabolite hmdb:HMDB0000464
PGI2 Metabolite hmdb:HMDB0001335
Progesterone Metabolite cas:57-83-0
PGE2 Metabolite hmdb:HMDB0003175
TXA2 Metabolite hmdb:HMDB0001452
Cortisol Metabolite wikidata:Q190875
Arachidonic Acid Metabolite cas:506-32-1
PGF2a Metabolite hmdb:HMDB0001139
EDNRA GeneProduct ensembl:ENSBTAG00000013674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1909
PGHS-2 GeneProduct ensembl:ENSBTAG00000014127 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
EDNRB GeneProduct ensembl:ENSBTAG00000005299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1910
PTGIS GeneProduct ensembl:ENSBTAG00000017537 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5740
S100A10 GeneProduct ensembl:ENSBTAG00000015147 PMID: 12962548 relationship with Annexin 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6281
PRL GeneProduct ensembl:ENSBTAG00000015274 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5617
HPGD GeneProduct ensembl:ENSBTAG00000025942 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3248
ANXA3 GeneProduct ensembl:ENSBTAG00000010153 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:306
TBXAS1 GeneProduct ensembl:ENSBTAG00000020225 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6916
ANXA8 GeneProduct ensembl:ENSBTAG00000018499 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:244
PTGIR GeneProduct ensembl:ENSBTAG00000014585 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5739
ANXA5 GeneProduct ensembl:ENSBTAG00000021746 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:308
HSD11B1 GeneProduct ensembl:ENSBTAG00000015086 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3290
PLA2G4A GeneProduct ensembl:ENSBTAG00000013298 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5321
PTGS1 GeneProduct ensembl:ENSBTAG00000006716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5742
PTGDS GeneProduct ensembl:ENSBTAG00000015074 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5730
ANXA1 GeneProduct ensembl:ENSBTAG00000015978 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:301
PTGDR GeneProduct ensembl:ENSBTAG00000006703 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5729
CYP11A1 GeneProduct ensembl:ENSBTAG00000006934 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1583
ANXA4 GeneProduct ensembl:ENSBTAG00000001105 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:307
EP1 GeneProduct ensembl:ENSBTAG00000017041 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5731
HSD11B2 GeneProduct ensembl:ENSBTAG00000005685 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3291
PTGER4 GeneProduct ensembl:ENSBTAG00000014972 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5734
FP GeneProduct ensembl:ENSBTAG00000015902 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5737
ANXA6 GeneProduct ensembl:ENSBTAG00000014809 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:309
SCGB1A1 GeneProduct ensembl:ENSBTAG00000032918 PMID: 7615804, PMID: 3292559
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7356
PTGER2 GeneProduct ensembl:ENSBTAG00000002163 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5732
PTGER3 GeneProduct ensembl:ENSBTAG00000019230 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5733
ANXA2 GeneProduct ensembl:ENSBTAG00000009615 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:302
EDN1 GeneProduct ensembl:ENSBTAG00000008096 PMID: 1474344
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1906

References

  1. Gene knockout mice in the study of parturition. Gross G, Imamura T, Muglia LJ. J Soc Gynecol Investig. 2000;7(2):88–95. PubMed Europe PMC Scholia