Notch signaling pathway (WP208)

Drosophila melanogaster

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes. Source: [ KEGG] Adapted from KEGG:


Austin J. Carolo , Thomas Kelder , Daniela Digles , Kristina Hanspers , Egon Willighagen , Lotte Sevenich , Lauren J. Dupuis , and Eric Weitz


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Drosophila melanogaster



Pathway Ontology

Notch signaling pathway


Label Type Compact URI Comment
Numb GeneProduct flybase:FBgn0002973
Dsh GeneProduct flybase:FBgn0000499
Delta GeneProduct uniprot:DL_DROME
Fringe GeneProduct flybase:FBgn0011591
Su(H) GeneProduct uniprot:RBJK_DROME
Groucho GeneProduct flybase:FBgn0001139
E(spl)-C GeneProduct uniprot:ESM8_DROME
Delta GeneProduct uniprot:DL_DROME
Sc GeneProduct flybase:FBgn0004170
Notch GeneProduct uniprot:NOTC_DROME
hairless GeneProduct flybase:FBgn0001169
Notch GeneProduct uniprot:NOTC_DROME
Deltex GeneProduct flybase:FBgn0000524
Serrate GeneProduct flybase:FBgn0004197
Ac GeneProduct flybase:FBgn0000022
Vg GeneProduct flybase:FBgn0003975
Delta GeneProduct uniprot:DL_DROME
presenilin GeneProduct flybase:FBgn0019947


  1. The ins and outs of notch signaling. Weinmaster G. Mol Cell Neurosci. 1997;9(2):91–102. PubMed Europe PMC Scholia