Clock-controlled autophagy in bone metabolism (WP5205)

Homo sapiens

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This is an integrated Pathway showing the cross talk among Circadian Rhythm, Autophagy and Osteoclast/Osteoblast Differentiation pathways. The Pathway shows different other pathways as activators and/or inhibitors of the bone remodeling process.

Authors

Haseena Noureen , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

autophagy pathway

Cell Type Ontology

osteoclast osteoblast osteocyte

Participants
Query Drugst.One

Label Type Compact URI Comment
S1P Metabolite chebi:37550
BMP Metabolite chebi:60815
CLOCK GeneProduct ensembl:ENSG00000134852
ARNTL GeneProduct ensembl:ENSG00000133794
PER1 GeneProduct ensembl:ENSG00000179094
CRY1 GeneProduct ensembl:ENSG00000008405
MTOR GeneProduct ensembl:ENSG00000198793
ULK1 GeneProduct ensembl:ENSG00000177169
ATG13 GeneProduct ensembl:ENSG00000175224
NFATC1 GeneProduct ensembl:ENSG00000131196
ATG5 GeneProduct ensembl:ENSG00000057663
ATG16L1 GeneProduct ensembl:ENSG00000085978
ATG12 GeneProduct ensembl:ENSG00000145782
BECN1 GeneProduct ensembl:ENSG00000126581
RANKL GeneProduct ensembl:ENSG00000141655
RB1CC1 GeneProduct ensembl:ENSG00000023287
PIK3C3 GeneProduct ensembl:ENSG00000078142
ATG101 GeneProduct ensembl:ENSG00000123395
OPG GeneProduct ensembl:ENSG00000164761
RANK GeneProduct ensembl:ENSG00000120659
AMBRA1 GeneProduct ensembl:ENSG00000110497
CTSK GeneProduct ensembl:ENSG00000143387
P115 GeneProduct ensembl:ENSG00000089820
BECN1 GeneProduct ensembl:ENSG00000126581
SMAD8 GeneProduct ensembl:ENSG00000120693
SMAD5 GeneProduct ensembl:ENSG00000113658
SMAD1 GeneProduct ensembl:ENSG00000170365
AMPK GeneProduct ensembl:ENSG00000162409
BMP1 GeneProduct ensembl:ENSG00000125845
LAMP2 GeneProduct ensembl:ENSG00000005893
WNT16 GeneProduct ensembl:ENSG00000002745
SEMA3A GeneProduct ensembl:ENSG00000075213
WNT5A GeneProduct ensembl:ENSG00000114251
TRAP GeneProduct ensembl:ENSG00000126602
MAP1LC3A GeneProduct ensembl:ENSG00000101460
MAP1LC3B GeneProduct ensembl:ENSG00000140941
IGF1 GeneProduct ensembl:ENSG00000017427
DKK1 GeneProduct ensembl:ENSG00000107984
SEMA4D GeneProduct ensembl:ENSG00000187764
WNT10B GeneProduct ensembl:ENSG00000169884
CTHRC1 GeneProduct ensembl:ENSG00000164932
EFNB2 GeneProduct ensembl:ENSG00000125266
CT-1 GeneProduct ensembl:ENSG00000150281
TGFB1 GeneProduct ensembl:ENSG00000105329
RUNX2 GeneProduct ensembl:ENSG00000124813
NFATC1 GeneProduct ensembl:ENSG00000131196
LEP GeneProduct ensembl:ENSG00000174697
RORB GeneProduct ensembl:ENSG00000198963
NPAS2 GeneProduct ensembl:ENSG00000170485
NR1D2 GeneProduct ensembl:ENSG00000174738
BHLHE40 GeneProduct ensembl:ENSG00000134107
BHLHE41 GeneProduct ensembl:ENSG00000123095
NOTCH1 GeneProduct ensembl:ENSG00000148400
BCL2 GeneProduct ensembl:ENSG00000171791
VCP GeneProduct ensembl:ENSG00000165280
FYCO1 GeneProduct ensembl:ENSG00000163820
PLEKHM1 GeneProduct ensembl:ENSG00000225190
DRAM2 GeneProduct ensembl:ENSG00000156171
BMP2 GeneProduct ensembl:ENSG00000152785
BMP4 GeneProduct ensembl:ENSG00000125378
BMPR2 GeneProduct ensembl:ENSG00000204217
BMP5 GeneProduct ensembl:ENSG00000112175
BMP6 GeneProduct ensembl:ENSG00000153162
CALCA GeneProduct ensembl:ENSG00000110680
VCP GeneProduct ensembl:ENSG00000165280
SMAD4 GeneProduct ensembl:ENSG00000141646
SERPINF1 GeneProduct ensembl:ENSG00000132386
PTH GeneProduct ensembl:ENSG00000152266
CSF1 GeneProduct ensembl:ENSG00000184371
JAK2 GeneProduct ensembl:ENSG00000096968
LRP5 GeneProduct ensembl:ENSG00000162337
CHRD GeneProduct ensembl:ENSG00000090539
MEPE GeneProduct ensembl:ENSG00000152595
MEPE GeneProduct ensembl:ENSG00000152595
AKT1 GeneProduct ensembl:ENSG00000142208
ATG10 GeneProduct ensembl:ENSG00000152348
HMGB1 GeneProduct ensembl:ENSG00000189403
SQSTM1 GeneProduct ensembl:ENSG00000161011
RUNX2 GeneProduct ensembl:ENSG00000124813
PTH GeneProduct ensembl:ENSG00000152266
IL3 GeneProduct ensembl:ENSG00000164399
IL6 GeneProduct ensembl:ENSG00000136244
ATG7 GeneProduct ensembl:ENSG00000197548
SOST GeneProduct ensembl:ENSG00000167941
ATG4C GeneProduct ensembl:ENSG00000125703
ATG7 GeneProduct ensembl:ENSG00000197548
ATG5 GeneProduct ensembl:ENSG00000057663
NOTCH1 GeneProduct ensembl:ENSG00000148400
ATG3 GeneProduct ensembl:ENSG00000144848
VCP GeneProduct ensembl:ENSG00000165280
IL3,6,7 GeneProduct ensembl:ENSG00000164399
TRAF6 GeneProduct ensembl:ENSG00000175104
PTH GeneProduct ensembl:ENSG00000152266
BMP7 GeneProduct ensembl:ENSG00000153162
Rev-Erb GeneProduct ensembl:ENSG00000008405
MMP9 GeneProduct ensembl:ENSG00000008405
CX3CR1 GeneProduct ensembl:ENSG00000008405
IL1/4/6/7 GeneProduct ensembl:ENSG00000120659
TNF-a GeneProduct ensembl:ENSG00000120659
WNT6 GeneProduct ensembl:ENSG00000114251
WNT10a GeneProduct ensembl:ENSG00000114251
SP7 GeneProduct ensembl:ENSG00000170374
ATG4 GeneProduct ensembl:ENSG00000197548

References

  1. Gremlin, Noggin, Chordin and follistatin differentially modulate BMP induced suppression of androgen secretion by bovine ovarian theca cells. Glister C, Regan SL, Samir M, Knight P. J Mol Endocrinol. 2018 Oct 1;JME-18-0198.R1. PubMed Europe PMC Scholia