Hippo-YAP signaling (WP4537)

Homo sapiens

When the Hippo-YAP pathway is in the "ON" state, YAP and TAZ are phosphorylated and held in cytoplasm. When the pathway is in the "OFF" state, unphosphorylated YAP and TAZ accumulate in the nucleus with TEAD.


Martina Summer-Kutmon and Eric Weitz


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Homo sapiens



Pathway Ontology

Hippo signaling pathway


Label Type Compact Identifier Comment
YWHAQ GeneProduct ncbigene:10971 14-3-3
LATS2 GeneProduct ncbigene:26524 LATS1/2
CXCL10 GeneProduct ncbigene:3627 MOB1
STK3 GeneProduct ncbigene:6788 MST1/2
STK38L GeneProduct ncbigene:23012 NDR1/2
SAV1 GeneProduct ncbigene:60485 SAV1
LATS1 GeneProduct ncbigene:9113 LATS1/2
YY1AP1 GeneProduct ncbigene:55249 YAP/TAZ
MINK1 GeneProduct ensembl:ENSG00000141503
TNIK GeneProduct ensembl:ENSG00000154310
NF2 GeneProduct ncbigene:4771 Nf2
NDRG1 GeneProduct ncbigene:10397 NDR1/2
RASSF1 GeneProduct ensembl:ENSG00000068028
TAZ GeneProduct ncbigene:6901 YAP/TAZ
MST1 GeneProduct ncbigene:4485 MST1/2
MAP4K1 GeneProduct ensembl:ENSG00000104814
MAP4K2 GeneProduct ensembl:ENSG00000168067
MAP4K4 GeneProduct ensembl:ENSG00000071054
MAP4K3 GeneProduct ensembl:ENSG00000011566
TEAD1 GeneProduct ensembl:ENSG00000187079
YY1AP1 GeneProduct ncbigene:55249 YAP/TAZ
TAZ GeneProduct ncbigene:6901 YAP/TAZ
YY1AP1 GeneProduct ncbigene:55249 YAP/TAZ
TAZ GeneProduct ncbigene:6901 YAP/TAZ
TEAD2 GeneProduct ensembl:ENSG00000074219
TEAD3 GeneProduct ensembl:ENSG00000007866
TEAD4 GeneProduct ensembl:ENSG00000197905


  1. How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases. Zhou W, Zhao M. J Immunol Res. 2018 Feb 8;2018:3696914. PubMed Europe PMC Scholia