Androgen receptor signaling pathway (WP252)

Mus musculus

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The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: NetPath

For a description of pathway objects, see the WikiPathways Legend.

Authors

Akhilesh Pandey , Alex Pico , Kristina Hanspers , Christine Chichester , Lauren J. Dupuis , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

androgen signaling pathway

Participants

Label Type Compact URI Comment
Cdc2a GeneProduct ncbigene:12534
Hdac1 GeneProduct ncbigene:433759
Ar GeneProduct ncbigene:11835
Src GeneProduct ncbigene:20779
NCOA4 GeneProduct ncbigene:27057
Nr3c1 GeneProduct ncbigene:14815
Prmt1 GeneProduct ncbigene:15469
Rb1 GeneProduct ncbigene:19645
Etv5 GeneProduct ncbigene:104156
Pias4 GeneProduct ncbigene:59004
Esr1 GeneProduct ncbigene:13982
Bag1 GeneProduct ncbigene:12017
Hmgb2 GeneProduct ncbigene:97165
Raf1 GeneProduct ncbigene:110157
Ncor2 GeneProduct ncbigene:20602
Jun GeneProduct ncbigene:16476
Calr GeneProduct ncbigene:12317
Patz1 GeneProduct ncbigene:56218
RAS GeneProduct ncbigene:19412
Myst2 GeneProduct ncbigene:217127
Stat3 GeneProduct ncbigene:20848
Akt1 GeneProduct ncbigene:11651
Rnf14 GeneProduct ncbigene:56736
Ccne1 GeneProduct ncbigene:12447
Spdef GeneProduct ncbigene:30051
Rnf4 GeneProduct ncbigene:19822
Stub1 GeneProduct ncbigene:56424
Runx2 GeneProduct ncbigene:12393
Il6st GeneProduct ncbigene:16195
Senp1 GeneProduct ncbigene:223870
Pou2f2 GeneProduct ncbigene:18987
Nr0b2 GeneProduct ncbigene:23957
Ube2i GeneProduct ncbigene:22196
Atf2 GeneProduct ncbigene:11909
Igf1 GeneProduct ncbigene:16000
Smad4 GeneProduct ncbigene:17128
Nsd1 GeneProduct ncbigene:18193
COX5B GeneProduct ncbigene:12859
Ctnnb1 GeneProduct ncbigene:12387
Aes GeneProduct ncbigene:14797
Rchy1 GeneProduct ncbigene:68098
Il6 GeneProduct ncbigene:16193
Gtf2h1 GeneProduct ncbigene:14884
Cav1 GeneProduct ncbigene:12389
Ctdp1 GeneProduct ncbigene:67655
Ranbp9 GeneProduct ncbigene:56705
Uxt GeneProduct ncbigene:22294
Ccnh GeneProduct ncbigene:66671
Pten GeneProduct ncbigene:19211
Appl1 GeneProduct ncbigene:72993
Fhl2 GeneProduct ncbigene:14200
Gtf2f1 GeneProduct ncbigene:98053
Ube3a GeneProduct ncbigene:22215
Pnrc1 GeneProduct ncbigene:108767
Rela GeneProduct ncbigene:19697
Hmg1l1 GeneProduct ncbigene:434174
Egfr GeneProduct ncbigene:13649
Ghr GeneProduct ncbigene:14600
Pias2 GeneProduct ncbigene:17344
Trp53 GeneProduct ncbigene:22059
Nrip1 GeneProduct ncbigene:268903
Pak6 GeneProduct ncbigene:214230
Cdk7 GeneProduct ncbigene:12572
Ep300 GeneProduct ncbigene:328572
Slc25a4 GeneProduct ncbigene:11739
Flna GeneProduct ncbigene:192176
Rad54l2 GeneProduct ncbigene:81000
Hipk3 GeneProduct ncbigene:15259
Map2k1 GeneProduct ncbigene:26395
Casp1 GeneProduct ncbigene:12362
PLAGL1 GeneProduct ncbigene:22634
Ncoa2 GeneProduct ncbigene:17978
Brca1 GeneProduct ncbigene:12189
Esr2 GeneProduct ncbigene:13983
Nr2c2 GeneProduct ncbigene:22026
Tgif1 GeneProduct ncbigene:21815
Pias3 GeneProduct ncbigene:229615
Cdc25b GeneProduct ncbigene:12531
Mmp1a GeneProduct ncbigene:83995
Casp8 GeneProduct ncbigene:12370
SRY GeneProduct ncbigene:21674
Casp3 GeneProduct ncbigene:12367
Casp7 GeneProduct ncbigene:12369
HSPA1A GeneProduct ncbigene:193740
Pa2g4 GeneProduct ncbigene:18813
Nr5a1 GeneProduct ncbigene:26423
Svil GeneProduct ncbigene:225115
Nr0b1 GeneProduct ncbigene:11614
Crebbp GeneProduct ncbigene:12914
Ccnd1 GeneProduct ncbigene:12443
Ncoa1 GeneProduct ncbigene:17977
Gm13882 GeneProduct ncbigene:100043349
Mdm2 GeneProduct ncbigene:17246
Ywhah GeneProduct ncbigene:22629
Ran GeneProduct ncbigene:19384
Pxn GeneProduct ncbigene:19303
Pias1 GeneProduct ncbigene:56469
Tgfb1i1 GeneProduct ncbigene:21804
Ncoa3 GeneProduct ncbigene:17979
Smad3 GeneProduct ncbigene:17127
Rac3 GeneProduct ncbigene:170758
Sp1 GeneProduct ncbigene:20683
Kat5 GeneProduct ncbigene:81601
Pou2f1 GeneProduct ncbigene:18986
Mapk1 GeneProduct ncbigene:26413
Gtf2f2 GeneProduct ncbigene:68705
Cdk9 GeneProduct ncbigene:107951
Sin3a GeneProduct ncbigene:20466
Psmc3ip GeneProduct ncbigene:19183
Tmf1 GeneProduct ncbigene:232286
RUNX1 GeneProduct ncbigene:12394
Cdc37 GeneProduct ncbigene:12539

References

  1. Biological actions of androgens. Mooradian AD, Morley JE, Korenman SG. Endocr Rev. 1987 Feb;8(1):1–28. PubMed Europe PMC Scholia
  2. Progestins can mimic, inhibit and potentiate the actions of androgens. Bardin CW, Brown T, Isomaa VV, Jänne OA. Pharmacol Ther. 1983;23(3):443–59. PubMed Europe PMC Scholia
  3. Regulation of androgen action. Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, et al. Vitam Horm. 1999;55:309–52. PubMed Europe PMC Scholia
  4. The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Heinlein CA, Chang C. Mol Endocrinol. 2002 Oct;16(10):2181–7. PubMed Europe PMC Scholia
  5. Anabolic steroids, testosterone-precursors and virilizing androgens induce distinct activation profiles of androgen responsive promoter constructs. Holterhus PM, Piefke S, Hiort O. J Steroid Biochem Mol Biol. 2002 Nov;82(4–5):269–75. PubMed Europe PMC Scholia
  6. Progestogens with antiandrogenic properties. Raudrant D, Rabe T. Drugs. 2003;63(5):463–92. PubMed Europe PMC Scholia
  7. Androgen physiology. Davison SL, Bell R. Semin Reprod Med. 2006 Apr;24(2):71–7. PubMed Europe PMC Scholia