Nod-like receptor (NLR) signaling pathway (WP799)

Gallus gallus

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.


Alex Pico , Egon Willighagen , Elisa Cirillo , Eric Weitz , and Finterly Hu


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Gallus gallus



Pathway Ontology

signaling pathway signaling pathway pertinent to immunity


Label Type Compact URI Comment
MAP3K7 GeneProduct ncbigene:421808
ERBB2IP GeneProduct ncbigene:431583
EPHB2 GeneProduct ncbigene:396513
MAPK8 GeneProduct ncbigene:423778
RCJMB04_19h23 GeneProduct ncbigene:423669
IKBKB GeneProduct ncbigene:426792
CD40 GeneProduct ncbigene:395385


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