Bone morphogenic protein signaling and regulation (WP1425)
Homo sapiens
"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." [http://www.ncbi.nlm.nih.gov/pubmed/15621726 (Chen 2004)]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1425 CPTAC Assay Portal]
Authors
Andra Waagmeester , Kristina Hanspers , Alex Pico , Vfunari , Babiker Malik Osman , Martijn Van Iersel , Marianthi Kalafati , Eric Weitz , and Egon WillighagenActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
Bone morphogenetic proteins signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| RUNX2 | GeneProduct | ensembl:ENSG00000124813 | |
| SMAD6 | GeneProduct | ensembl:ENSG00000137834 | |
| SMURF1 | GeneProduct | ensembl:ENSG00000198742 | |
| TOB1 | GeneProduct | ensembl:ENSG00000141232 | |
| SMAD1 | GeneProduct | ensembl:ENSG00000170365 | |
| BMPR1A | GeneProduct | ensembl:ENSG00000107779 | |
| SMAD1 | GeneProduct | ensembl:ENSG00000170365 | |
| NOG | GeneProduct | ensembl:ENSG00000183691 | |
| BMPR2 | GeneProduct | ncbigene:659 | |
| SMAD6 | GeneProduct | ensembl:ENSG00000137834 | |
| SMAD4 | GeneProduct | ensembl:ENSG00000141646 | |
| BMP2 | GeneProduct | ensembl:ENSG00000125845 | |
| SMAD1 | GeneProduct | ensembl:ENSG00000170365 | |
| SMAD1 | GeneProduct | ensembl:ENSG00000170365 | |
| TOB2 | GeneProduct | ensembl:ENSG00000183864 | |
| SMURF1 | GeneProduct | ensembl:ENSG00000198742 | |
| SMURF1 | GeneProduct | ensembl:ENSG00000198742 | |
| SMURF1 | GeneProduct | ensembl:ENSG00000198742 | |
| SMAD1 | GeneProduct | ensembl:ENSG00000170365 | |
| BMPR1B | GeneProduct | ensembl:ENSG00000138696 |
References
- Bone morphogenetic proteins. Chen D, Zhao M, Mundy GR. Growth Factors. 2004 Dec;22(4):233–41. PubMed Europe PMC Scholia